A5026064742- Systemic Lupus Erythematosus Research
- SARS-CoV-2 and COVID-19 Research
- Atherosclerosis and Cardiovascular Diseases
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Autoimmune and Inflammatory Disorders Research
- Immune responses and vaccinations
- Monoclonal and Polyclonal Antibodies Research
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Animal Virus Infections Studies
- Gene expression and cancer classification
- Cancer Cells and Metastasis
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Immune cells in cancer
- Cytokine Signaling Pathways and Interactions
SingHealth Duke-NUS Academic Medical Centre
2020-2024
Duke-NUS Medical School
2015-2024
KK Women's and Children's Hospital
2023-2024
SingHealth
2024
National University of Singapore
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
State Key Laboratory of Medical Molecular Biology
2023
German Rheumatism Research Centre
2023
University Medical Center Utrecht
2023
Peking Union Medical College Hospital
2023
Abstract Objectives Immunogenicity to the SARS-CoV-2 mRNA vaccines in adolescents and young adults (AYA) with childhood-onset rheumatic diseases (cRD) is unknown. We aimed evaluate humoral immunogenicity safety of our AYA cRD. Methods A monocentric observational study 159 (50.3% female 70.4% Chinese). Humoral was assessed at 2–3 4–6 weeks following first second vaccination by cPass™ Neutralization Antibody Assay. Inhibition signal ≥30% defined cut-off for positive detection neutralizing...
Astroviruses are comprised of two genera with Avastrovirus infecting birds and Mamastrovirus mammals. Avastroviruses have primarily been associated infections poultry, especially chicken, turkey, duck, guineafowl production systems, but also infect wading doves. Outcomes result in a spectrum disease, ranging from asymptomatic shedding to gastroenteritis diarrhea, stunting, failure thrive death. Virological surveillance was conducted sites Cambodia 2010. Samples were screened for influenza,...
An accurate depiction of the convalescent COVID-19 immunome will help delineate immunological milieu crucial for disease resolution and protection. Using mass cytometry, we characterized immune architecture in patients recovering from mild COVID-19. We identified a virus-specific rheostat composed an effector T (T eff ) cell recall response that is balanced by enrichment highly specialized regulatory reg subset. Both components were reactive against peptide pool covering receptor binding...
To evaluate the humoral immunogenicity for 6 months after two-dose coronavirus disease 2019 (COVID-19) mRNA vaccination in adolescents and young adults (AYAs) with childhood-onset rheumatic diseases (cRDs).This monocentric observational study was conducted between August 2020 March 2022. Humoral assessed at 2-3 weeks first vaccine dose 1, 3 second by cPass™ severe acute respiratory syndrome 2 (SARS-CoV-2) neutralization antibody (nAb) assay. An inhibition signal of ≥30% defined...
<h3>Background:</h3> Systemic sclerosis (SSc) is a heterogenous disease characterised by autoimmunity, vasculopathy, and fibrosis. <h3>Objectives:</h3> This study aimed to characterize the peripheral immunome associated with active in systemic sclerosis. Our findings will shed light into SSc pathogenesis. Furthermore, our provide an opportunity develop potential theragnostic tool evaluate early stage SSc. <h3>Methods:</h3> Peripheral blood mononuclear cells (PBMC) were collected from...
<h3>Background:</h3> Systemic Lupus Erythematosus (SLE) is a complex disease afflicting children and adults. Patients with childhood-onset SLE (cSLE) tend to have more severe clinical manifestations are vulnerable the toxicity of steroids on bone health growth. Despite these, cSLE treatment often extrapolated from adult studies assumption that underlying mechanisms similar. Its immunopathogenic complexity lack insight into differences between childhood adult-onset lupus demand holistic,...
<h3>Background:</h3> Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) is a crucial immune checkpoint inhibitor expressed on CD4<sup>+</sup>Foxp3<sup>+</sup>CD25<sup>+</sup> regulatory cells (Tregs), essential for maintaining homeostasis and preventing auto-reactivity. Interestingly, CTLA-4 also CD4<sup>+</sup>Foxp3<sup>-</sup>CD25<sup>-</sup> non-Treg effector (Teffs). We observed significant reduction in expressing Teffs adult lupus compared to age-matched healthy controls, suggesting...
<h3>Background:</h3> Childhood-onset systemic lupus erythematosus (cSLE) is an autoimmune disease characterized by more severe clinical manifestations than adults. Heterogeneous warrants diverse and laboratory criteria for diagnosis, which challenging unmet need. To capture this inherent heterogeneity, a diagnostic model reveals underlying mechanistic immune perturbations can augment current while imparting theragnostic perspective to cSLE. <h3>Objectives:</h3> We aim resolve...
<h3>Background</h3> Systemic Lupus Erythematosus (SLE) immunopathogenesis involves a complex network of regulatory and effector cells with its balance constituting an immune rheostat that maintains homeostasis. Thus, the disease must be interrogated holistically to identify mechanistically clinically relevant cell subsets for pathogenesis. There is crucial unmet need examine mechanism tolerance loss in lupus novel targets potential therapeutic intervention improve outcomes....
<h3>Background</h3> Systemic lupus erythematosus (SLE) is a complex, systemic autoimmune disease. Disease presentation heterogeneous and characterized by alternating flares remissions. Recent treatment developments have been made with FDA approval of anifrolumab for adult SLE in 2021 <sup>[1]</sup> but there are many patients inadequate therapeutic response. Furthermore, lack specific molecular targets, current therapy relies mainly on general immunosuppression. This can adversely affect...
Background: Systemic lupus erythematosus (SLE) is a complex, systemic autoimmune disease that interferes with the balance between regulation and immunity, resulting in immune system dysfunction. Disease course unpredictable due to alternating remissions flares 1 . activity treatment response are measured composite scores such as SLE Activity Index (SLEDAI) 2 However, heterogeneity can impede reliable patient assessments. Mechanistic insights into required for better assessment. Current...