A5054119242- Per- and polyfluoroalkyl substances research
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Heavy metals in environment
- Environmental Justice and Health Disparities
- Effects and risks of endocrine disrupting chemicals
- Atmospheric chemistry and aerosols
- Risk and Safety Analysis
- Water Systems and Optimization
- Trace Elements in Health
- Environmental Toxicology and Ecotoxicology
- Aluminum toxicity and tolerance in plants and animals
- Soil Geostatistics and Mapping
- Nuclear and radioactivity studies
- Geochemistry and Geologic Mapping
- Water Quality and Resources Studies
- Water-Energy-Food Nexus Studies
- Environmental and Social Impact Assessments
- Advanced Statistical Process Monitoring
- Spatial and Panel Data Analysis
- Pesticide Residue Analysis and Safety
- Recycling and Waste Management Techniques
- Water resources management and optimization
- Urban Stormwater Management Solutions
GSI Environmental (United States)
2020-2024
SUNY College of Environmental Science and Forestry
1996-2022
State University of New York
2022
Integral Consulting (United States)
2017-2019
Syracuse University
2017
SRC
1996-2005
Purchase College
1996
Environmental occurrence and biomonitoring data for per- polyfluoroalkyl substances (PFAS) demonstrate that humans are exposed to mixtures of PFAS. This article presents a new systematic analysis available PFAS toxicity study using tiered risk assessment framework consistent with United States international guidance. The lines evidence presented herein include critique whole mixture studies dose-response models based on from subchronic oral in rats. Based to-date, concentration addition...
The Cadmium Dietary Exposure Model (CDEM) utilizes national survey data on food cadmium concentrations and consumption patterns to estimate dietary intakes in the U.S. population. CDEM has been linked a modification of biokinetic model Kjellström Nordberg (KNM) derive predictions kidney urinary that reflect intake related variability. Variability was propagated through KNM using Monte Carlo approach. predicts mean peak burden approximately 3.5 mg 5th-95th percentile range 2.2-5.1 males....
Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon perfluoroalkyl (PFAA) and primary impurity, degradant, metabolite associated with the short-chain fluorotelomer-based chemistry used globally today. The transition to products as cornerstone in replacement fluorochemistry has raised questions regarding potential human health risks exposure substances therefore, PFHxA. Here, we present critical review of data relevant such risk assessment, including epidemiological studies vivo vitro...
Perfluorohexanoic acid (PFHxA) is a short-chain, six-carbon PFAA and primary impurity, degradant, metabolite associated with the short-chain fluorotelomer-based chemistry used in United States, Europe Japan today. With shift towards chemistry, uncertainties remain regarding human health risks current exposure levels. Here, we present critical review assessment of data relevant to risk today's chemistry. Human biomonitoring surveys indicate that PFHxA infrequently detected environment as well...
Estimating gastrointestinal absorption remains a significant challenge in the risk assessment of metals. This presentation reviews our current understanding lead (Pb) to illustrate physiological mechanisms involved metal absorption, new approaches that are being applied problem estimating humans, and issues related integrating this information into assessment.Absorption metals can be highly variable human populations because it is influenced by variety factors include chemical form metal,...
Over the last 10 years, a number of researchers have used Monte Carlo analysts to investigate variation in long‐term average dose rates exposed populations and uncertainty estimates for specific individuals. In general, these modeled exposures using simple rate equations which assume that individuals are single environmental concentration at constant over specified exposure duration. This paper presents an alternative approach modeling called microexposure event addresses shortcomings...
Geostatistics offers two fundamental contributions to environmental contaminant exposure assessment: (1) a group of methods quantitatively describe the spatial distribution pollutant and (2) ability improve estimates point concentration by exploiting geospatial information present in data. The second contribution is particularly valuable when must be derived from small data sets, which often case risk assessment. This article addresses topics related use geostatistics human ecological...
Abstract An integrated stochastic exposure (ISE) model using microexposure techniques was developed to characterize short‐term variability and uncertainty in residential childhood lead at the census tract level. The ISE linked biokinetic module of United States Environmental Protection Agency (USEPA) IEUBK Model for Lead Children (v. .99D) predict distribution blood concentrations (PbB). We demonstrate an application probability distributions age‐specific physiology activity patterns,...
Exposure of children to lead in the environment was assessed at Murray Smelter Superfund site using both a deterministic risk assessment approach, Integrated Uptake Biokinetic (IEUBK) model, and probabilistic Stochastic (ISE) model. When site-specific data on environmental media were input as point estimates into IEUBK unacceptable risks predicted for living within five eight study zones. The soil cleanup goal 550 ppm. Concentration exposure then ISE model probability distribution functions...
Per- and polyfluoroalkyl substances (PFASs) are a major priority for many federal state regulatory agencies charged with monitoring levels of emerging contaminants in environmental media setting health-protective benchmarks to guide risk assessments. While screening toxicity reference values have been developed numerous individual PFAS compounds, there remain important data gaps regarding the mode action mixtures. The present study aims contribute whole-mixture advance methods evaluating...
ABSTRACT In 1996, the U.S. Environmental Protection Agency (USEPA) developed Adult Lead Methodology (ALM) to provide an interim approach assessing risks from non-residential exposures lead. Because such often involve occupational activities of adults, ALM was directed at soil-related lead adults. Consistent with other approaches used in Superfund risk assessment, designed predict quasi-steady state blood concentrations (PbB) that might result soil exposure. These predictions are converted a...
This article presents a supplemental data analysis and evaluation of the findings from an oral (gavage) combined developmental perinatal/postnatal reproduction toxicity study ammonium salt perfluorohexanoic acid (CASRN: 21615-47-4) in Crl: CD-1(ICR) mice. The original has been cited as supporting lowest-observed-adverse-effects level 175 mg/kg/d no-observed-adverse-effects 35 for effects (PFHxA, CASRN: 307-24-4) statistical reported 2014 was accurate terms quantifying significance within...
Exposure of children to lead in the environment was assessed at Murray Smelter Superfund site using both a deterministic risk assessment approach, Integrated Uptake Biokinetic (IEUBK) model, and probabilistic Stochastic (ISE) model. When site-specific data on environmental media were input as point estimates into IEUBK unacceptable risks predicted for living within five eight study zones. The soil cleanup goal 550 ppm. Concentration exposure then ISE model probability distribution functions...
Abstract This article presents the findings from a numerical simulation study that was conducted to evaluate performance of alternative statistical analysis methods for background screening assessments when data sets are generated with incremental sampling (ISMs). A wide range and site conditions represented in order test different ISM designs. Both hypothesis tests upper tolerance limit (UTL) were implemented following U.S. Environmental Protection Agency (USEPA) guidance specifying error...
ABSTRACT One useful tool for assessing the potential adverse effects of oil spills on aquatic and marine environments are computational models that calculate transport, fate substances. The use is authorized by 43 CFR 11, has been codified in Natural Resources Damage Assessment Coastal Marine Environments (NRDAM/CME). code NRDAM/CME incorporated into modules compute how a spilled substance moves through environment affects biological resources. This paper describes an apparent error one...