A5027691318- Heavy Metal Exposure and Toxicity
- Heavy metals in environment
- Environmental Justice and Health Disparities
- Connexins and lens biology
- Radioactivity and Radon Measurements
- Advanced Glycation End Products research
- Biochemical effects in animals
- Healthcare cost, quality, practices
- Pharmacogenetics and Drug Metabolism
- Liver Disease Diagnosis and Treatment
- Alcohol Consumption and Health Effects
- Carcinogens and Genotoxicity Assessment
- Nitric Oxide and Endothelin Effects
- Drug-Induced Hepatotoxicity and Protection
- Renin-Angiotensin System Studies
- Contact Dermatitis and Allergies
- Chronic Kidney Disease and Diabetes
- Therapeutic Uses of Natural Elements
- Receptor Mechanisms and Signaling
SRC
2003-2022
Pennsylvania State University
1995-1998
Increased hepatic oxidative stress with ethanol administration is hypothesized to be caused either by enhanced pro-oxidant production or decreased levels of antioxidants both. We used the intragastric feeding rat model assess relationship between antioxidant enzymes and pathological liver injury in animals fed different dietary fats. Male Wistar rats (5 per group) were medium-chain triglycerides (MCTE), palm oil (PE), corn (CE), fish (FE). Control isocaloric amounts dextrose instead same...
1,3-Butadiene is carcinogenic in B6C3F1 mice and Sprague-Dawley rats, has been classified as a probable human carcinogen. The genetic basis for butadiene carcinogenicity likely mediated by its metabolite, 1,2:3,4-diepoxybutane (BDE). Oxidation of to 1,2-epoxy-3-butene (BMO) further activation BDE catalysed cytochrome P450 (CYP) isozymes. production BMO from CYP2E1 and, at high concentrations, CYP2A6. purpose the present study was identify which CYP isozymes have ability oxidize BDE,...
Background: Lead exposures from legacy sources threaten children's health. Soil in Omaha, Nebraska, was contaminated by emissions a lead smelter and refinery. The U.S. Environmental Protection Agency excavated replaced soil at the Omaha Superfund Site between 1999 2016. Objectives: goal of this study to assess association level (SLL) remediation status with blood levels (BLLs) children living near or on site. Methods: We linked information SLL residential properties BLLs assigned BLL...
ABSTRACT In 1996, the U.S. Environmental Protection Agency (USEPA) developed Adult Lead Methodology (ALM) to provide an interim approach assessing risks from non-residential exposures lead. Because such often involve occupational activities of adults, ALM was directed at soil-related lead adults. Consistent with other approaches used in Superfund risk assessment, designed predict quasi-steady state blood concentrations (PbB) that might result soil exposure. These predictions are converted a...
Blood lead (Pb) clearance (CbPb) and serum creatinine (CsCr), a metric of glomerular filtration rate (GFR), were estimated in approximately 7,600 subjects from the NHANES (2009–2016). Median CbPb adults was 0.04 L/day (5th-95th percentile range: 0.01–0.12). Linear regression models explained 68% variance adults, with >98% attributed to CsCr. These results provide an improved quantitative understanding possible effects reverse causality interpretation studies associations between blood Pb...
Typical exposures to lead often involve a mix of long-term relatively constant exposure levels (e.g., residential yard soil and indoor dust) highly intermittent at other locations seasonal recreational visits park). These types can be expected result in blood concentrations that vary on temporal scale with the pattern. Prediction short-term (or seasonal) arising from variable requires model reliably simulate biokinetics matches events interest. If averaging times (EMATs) exceed shortest...
This study was designed to determine whether pyrazinoylguanidine (PZG) can attenuate cataract development in streptozotocin (STZ)-induced diabetic rats. After a single, intraperitoneal dose of STZ (45 mg/kg 0.05 mol/l sodium citrate buffer), Sprague-Dawley rats (250-260 g) were divided into three groups. Beginning week later, each group received twice daily for 24 weeks by gavage one the following: vehicle (saline 10 ml/kg), PZG (35 mg/kg), or captopril (15 mg/kg). treatment prevented...
This study was designed to determine whether pyrazinoylguanidine (PZG) can attenuate diabetic nephropathy in streptozotocin (STZ)-induced rats. Diabetes induced within 1 week after a single intraperitoneal dose of STZ (45 mg/kg 0.05 mol/l sodium citrate buffer). Diabetic rats were divided into five groups. Each group received by gavage for 24 weeks one the following: vehicle (saline 10 ml/kg, b.i.d.), PZG (35 mg/kg, captopril (15 or hydrochlorothiazide (HCTZ, 20 b.i.d.). Insulin (NPH 7.5...
TPS 631: Metals and health 1, Johan Friso Foyer, Floor August 27, 2019, 3:00 PM - 4:30 Background: Lead is a toxic metal known to affect cognitive development in children even at low exposure levels. We examined the relationship between remediation activities, soil concentrations children's blood lead levels among living near smelter that operated from 1871-1997 Omaha, Nebraska. Methods: assembled cohort of with measurements surveillance program linked them U.S. Environmental Protection...