A5065974401- Heavy Metal Exposure and Toxicity
- Contact Dermatitis and Allergies
- Trace Elements in Health
- Carcinogens and Genotoxicity Assessment
- Orthopaedic implants and arthroplasty
- Effects and risks of endocrine disrupting chemicals
- Heavy metals in environment
- Animal testing and alternatives
- Drug Transport and Resistance Mechanisms
- Orthopedic Infections and Treatments
- Occupational exposure and asthma
- Iron Metabolism and Disorders
- Per- and polyfluoroalkyl substances research
- Drug-Induced Hepatotoxicity and Protection
- Pesticide Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Immunotoxicology and immune responses
- Skin Protection and Aging
- Arsenic contamination and mitigation
- Allergic Rhinitis and Sensitization
- Total Knee Arthroplasty Outcomes
- Air Quality and Health Impacts
- Occupational and environmental lung diseases
- Hair Growth and Disorders
- Computational Drug Discovery Methods
Cardno (United States)
2014-2023
Stantec (United States)
2022-2023
Amazon (United States)
2022
Purdue University West Lafayette
2010-2014
RMIT University
2009
University of Akron
2006
Regulation of cellular copper (Cu) homeostasis involves Cu-transporting ATPases (Cu-ATPases), i.e., ATP7A and ATP7B. The question as to how these Cu-ATPases in brain barrier systems transport Cu, toward parenchyma, cerebrospinal fluid (CSF), or blood, remained unanswered. This study was designed characterize roles regulating Cu at the blood-brain (BBB) blood-CSF (BCB) investigate exposure toxic manganese (Mn) altered function Cu-ATPases, thereby contributing etiology Mn-induced parkinsonian...
Cobalt (Co) is an essential element with human exposure occurring from the diet, supplement ingestion, occupational sources, and medical devices. The European Chemical Agency (ECHA) recently voted to classify Co metal as a Reproductive Hazard Category 1B; presumed reproductive toxicant due adverse testicular effects in male rodents. A weight of evidence evaluation preclinical developmental toxicity studies available clinical data was performed critically evaluate relevance this proposed...
As businesses attempt to reopen varying degrees amid the current coronavirus disease (COVID-19) pandemic, industrial hygiene (IH) and occupational environmental health safety (OEHS) professionals have been challenged with assessing managing risks of COVID-19 in workplace. In general, available IH/OEHS tools were designed control hazards originating workplace; however, attempts tailor them specifically infectious outbreaks limited. This analysis evaluated IH decision-making framework...
Concerns have recently been raised about the presence of heavy metals in protein powder supplements following a Consumer Reports analysis 15 products. The study found that average amounts three servings per day exceeded maximum limits dietary proposed by U.S. Pharmacopeia. In follow up to analysis, another reported 40 % 133 products they tested had elevated levels metals. objective this was determine whether metal concentrations posed any human health risks, based on arsenic (As), cadmium...
Cobalt (Co) alloys have been used for over seven decades in a wide range of medical devices, including, but not limited to, hip and knee implants, surgical tools, vascular stents, due to their favorable biocompatibility, durability, mechanical properties. A recent regulatory hazard classification review by the European Chemicals Agency (ECHA) resulted metallic Co as Class 1B Carcinogen (presumed carcinogenic potential humans), primarily based on inhalation rodent carcinogenicity studies with...
Copper (Cu) is an essential trace element that requires tight homeostatic regulation to ensure appropriate supply while not causing cytotoxicity due its strong redox potential. Our previous in vivo study has shown iron deficiency (FeD) increases Cu levels brain tissues, particularly the choroid plexus, where blood–cerebrospinal fluid (CSF) barrier resides. This was designed elucidate mechanism by which FeD results excess accumulation at blood–CSF barrier. The effect of on cellular retention...
Per- and polyfluoroalkyl substances (PFAS) are ubiquitous in the environment. Unlike other persistent chemicals, PFAS highly soluble water tend to partition surface groundwater rather than soil sediment. While numerous studies have evaluated potential ecological effects of certain PFAS, there remain data gaps, especially for newer PFAS. Consequently, this study a high-throughput silico approach screening-level risk assessment aquatic species. We focused on two well-studied perfluorooctanoic...
Recent concerns have been raised regarding heavy metal content in wine and its potential health implications. The goal of this study was to determine if lead (Pb) intake poses a risk among adult consumers wine. This achieved by performing literature review studies reporting Pb concentration United States international wines, determining consumption rates the using NHANES dietary survey data, utilizing U.S. EPA's Adult Lead Methodology (ALM) model estimate blood levels (BLLs) from under...