Background: We proposed hypothesis that obese and lean Indian type 2 diabetes mellitus patients would have diverse insulin secretory function clinical representation. conducted a study to compare serum Insulin, C-peptide levels, profile in patients. Materials Methods: Two hundred (100 underweight 100 obese) were selected. Underweight (lean) was defined as BMI <18.5 kg/m2 ≥ 25 according world health organization (WHO) Asia Pacific criteria. The demographic characteristics, profile,...

A simple, specific, and sufficiently sensitive liquid chromatography-tandem mass spectrometry (negative-ion electrospray ionization) methodology to determine mevalonic acid (MVA) in human plasma is described, its application the analysis of rat MVA levels after rosuvastatin administration demonstrated. The method was validated over linearity range 0.5-50.0 ng/ml (r(2) > 0.99) using deuterated as an internal standard. lower limit quantification 0.5 ng/ml. assay procedure involved isolation...

The current study investigated the role of guggulsterone (GS), a farnesoid X receptor antagonist, in choline metabolism and its trimethylamine (TMA)/flavin monooxygenases/trimethylamine- N-oxide (TMAO) inhibiting potential series vitro vivo studies as determined by high-performance liquid chromatography (HPLC), mass spectroscopy (MS), (LC)-MS techniques. Atherosclerosis (AS) was successfully induced group experimental animals fed with 2% diet for 6 weeks. Serum lipid profiles such total...

Background: Fever, characterized by an elevated body temperature beyond the normal range, necessitates effective management. Traditional therapies rooted in indigenous knowledge prove effective, addressing fever-related conditions for optimal well-being. This study explores antipyretic potential of Murraya koenigii, a plant deeply traditional practices Nepal. Materials and Methods: The hydroethanol leaf extract koenigii was subjected to phytochemical screening acute toxicity assessment,...

High utilization and irrational use of antibiotics in an intensive care unit increases microbial resistance, morbidity, mortality, costs.This study aimed to evaluate the utilization, sensitivity cost analysis used medical a tertiary teaching hospital Nepal.A prospective cohort was conducted on patients admitted at central Nepal from July September 2016. Antibiotic defined daily dose per 100 bed-days patient were calculated. Descriptive statistics performed using IBM-SPSS 20.0.A total 365...

We have examined a replication terminus (ψL1) located on the left arm of chromosome Bacillus subtilis and within yxcC gene at or near checkpoint that is activated under stringent conditions. The ψL1 sequence appears to bind two dimers terminator protein (RTP) rather weakly seems possess overlapping core auxiliary sites some similarities with normal Ter sites. Surprisingly, asymmetrical, isolated site arrested forks in vivo both orientations independent control.In vitro, DnaB helicase...

The current models that have been proposed to explain the mechanism of replication termination are (i) passive arrest a fork by terminus (Ter) DNA-terminator protein complex impedes and replicative helicase in polar fashion (ii) an active barrier model which Ter-terminator arrests not only DNA-protein interaction but also mechanistically significant terminator protein-helicase interaction. Despite existence some evidence supporting vitro between (RTP) DnaB helicase, there has continuing...

Background of the study: Depression is a prevalent mental disorder characterized by various symptoms, including low mood, lack pleasure, changes in appetite and sleep, difficulty concentrating. Antidepressants are commonly used to manage depression as well other related disorders, such anxiety somatoform disorders. This study aimed investigate adverse drug effects experienced adult patients who were using antidepressants at Chitwan Medical College Teaching Hospital Nepal. Methods: was...

Litchi chinensis is a edible fruits of soapberry family commonly known as lychee; traditionally used for the treatment inflammation, headache, and body pain. The present study investigated toxicity, anti-inflammatory, analgesic activity ethanolic crude extract to support its traditional use in folk medicine screen phytochemical constituents. 70% seeds (LCSE) was prepared preliminary screening performed. Acute toxicity LCSE carried out based on OECD guidelines 423. In vivo anti-inflammatory...

Introduction: The Psoriasis Disability Index (PDI) is a pre-validated, self-administered questionnaire assessing quality of life in adults suffering from psoriasis. English version contains 15 items measuring five components – activities, work/school performance, personal, leisure, and treatment. Purpose: We aimed to translate the PDI into Bengali examine its psychometric properties. Methods: PDI-Bengali (PDI-B) was produced by standardized forward-backward translations. A cross-sectional...

Background: Artificial intelligence (AI) has rapidly evolved, leading to significant technological advancements and raising important questions about its implications for society. This study examines the progress potential risks associated with AI development, drawing on historical milestones expert predictions outline both achievements failures. Ray Kurzweil's forecasts highlight a future where could surpass human intelligence, potentially new challenging scenarios. Aim: research aims...

The research was conducted from February to June 2023 assess the economics of production and marketing Tomatoes in Kaski. Pre-interview schedules, Focal Group Discussion (FGD), Key Informant Survey (KIS) were used collect primary information respondents, while secondary collected by reviewing different relevant publications. Altogether 61 respondents selected using simple random sampling for study Pokhara Metropolitan City within two wards namely Bagmara Budibazar. statistical tools, MS-...

An approach towards Information retrieval process security issues & accuracy of the retrieved data from user perspective, are major concerns this paper.Implanted work includes demonstration modes, flow information system and risk analysis data.Much has been done to highlight problem in content where an formula focuses on calculation percentage order generate transparent process.

Cancer biology as seen from chromosome 11 involves a plethora of mechanisms for chromosomal changes. The high frequency repeated elements, the presence active retrotransposons, appearance fragile sites, and (and amplification) drug resistance genes are all expected to destabilize integrity this chromosome. Thus, it is not unexpected that often mutated in variety tumors. Here, we review relevant lung carcinogenesis progression. Numerous loci will be omitted since their role appears restricted...

This paper is presented to explain the intersection of cloud computing (CC) and machine learning (ML), focusing on their synergies, challenges solutions. It shows changes in Internet service area led by economic impact data collection analysis. The document specifically addresses security issues distributed models introduces concept edge as a version for time-sensitive data. In this paper, we are discussing about encryption, distribution rights, transfer responsibility from providers end...

Mobile technologies have rapidly gained widespread adoption and provide significant advantages for businesses, including the ability to reach customers more effectively. These offer numerous benefits, such as interact from virtually anywhere, individualized usage, personalized information services, prompt responses. The advancement of mobile technology has facilitated transition traditional digital payment systems. For example, in Nepal, system "eSewa" was introduced by eSewa Fonepay 2009....

Internet overuse poses a serious risk to students and teenagers in the form of decreased face-to-face interaction, reduced outdoor creativity, cyberbullying, wastage time, abandonment family, invasion privacy, lack sleep, physical activity, low morale, psychological blocks, elimination book reading, etc., all which have an adverse effect on relationships, increased anxiety, excessive online spending1. In current study, information was gathered what degree college Udaipur knew about...