A5045792574- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
- Advanced Polymer Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Supramolecular Self-Assembly in Materials
- Multiple Sclerosis Research Studies
- Dendrimers and Hyperbranched Polymers
- Luminescence and Fluorescent Materials
- Monoclonal and Polyclonal Antibodies Research
- Polydiacetylene-based materials and applications
- Click Chemistry and Applications
- Bacteriophages and microbial interactions
- Nanoplatforms for cancer theranostics
- Hydrogels: synthesis, properties, applications
- DNA and Nucleic Acid Chemistry
- RNA regulation and disease
- Natural product bioactivities and synthesis
- Structural Engineering and Vibration Analysis
- Reproductive System and Pregnancy
- Cancer Research and Treatments
- Vibration and Dynamic Analysis
- biodegradable polymer synthesis and properties
- Synthetic Organic Chemistry Methods
- Cytokine Signaling Pathways and Interactions
University of Illinois Urbana-Champaign
2019-2025
Materials Science & Engineering
2025
Tongji University
2017-2023
Urbana University
2019-2021
University of Alberta
2018
RNA therapeutics have the potential to resolve a myriad of genetic diseases. Lipid nanoparticles (LNPs) are among most successful delivery systems. Expanding their use for treatment more diseases hinges on our ability continuously evolve design LNPs with high potency, cellular-specific targeting, and low side effects. Overcoming difficulty releasing cargo from endocytosed remains significant hurdle. Here, we investigate fundamental properties nonviral pertaining activation topological...
Synthetic polypeptides, the analogues of natural proteins, are important biomaterials that have found broad biomedical applications. Ring-opening polymerization N-carboxyanhydrides offers a reliable way to prepare high-molecular-weight polypeptides in large scale with diverse side-chain functionalities. The past two decades seen significant advances polypeptide field, development various controlled methodologies, deeper understanding on secondary structures, and discovery new assembly...
Abstract The recent advances in accelerated polymerization of N -carboxyanhydrides (NCAs) enriched the toolbox to prepare well-defined polypeptide materials. Herein we report use crown ether (CE) catalyze NCA initiated by conventional primary amine initiators solvents with low polarity and hydrogen-bonding ability. cyclic structure CE played a crucial role catalysis, 18-crown-6 enabling fastest kinetics. fast kinetics outpaced common side reactions, preparation polypeptides using an...
Hydrogels that are injectable, self-healing, and multiresponsive becoming increasingly relevant for a wide range of applications. In this work, we have successfully developed novel approach in the fabrication smart hydrogels with all above properties. A symmetrical ABA triblock copolymer was first synthesized via atom transfer radical polymerization temperature responsive middle block two permanently hydrophilic glycopolymer chains on both ends. were subsequently constructed by mixing...
Infections by intracellular pathogens are difficult to treat because of the poor accessibility antibiotics encased host cell membranes. As such, a strategy that can improve membrane permeability would significantly increase their efficiency against pathogens. Here, we report design an adaptive, metaphilic cell-penetrating polypeptide (CPP)–antibiotic conjugate (VPP-G) effectively eradicate bacteria both in vitro and vivo. VPP-G was synthesized attaching vancomycin highly membrane-penetrative...
Abstract Estrogen, a steroid hormone synthesized by both gonadal and non-gonadal tissues, plays pivotal role in modulating immune responses, including reducing relapse rates relapsing-remitting multiple sclerosis (MS). This study explored the expression of aromatase, enzyme responsible for estrogen synthesis, lymph nodes (LNs) its potential pathogenesis MS using mouse model. We utilized Cyp19-RFP mice, where cells that express or have previously expressed Cyp19 gene (encoding aromatase) are...
Lipid nanoparticle (LNP)-based mRNA delivery has a lot of potential in combating wide range diseases, but delivering to specific cell types continues be challenging. Despite recent advances organ and specificity, the majority clinical LNP systems cannot fully release their payload targeted site. Incorporating active targeting moieties into LNPs is highly desired expand nanomedicine applications. In this Letter, we developed that harness power bioorthogonal "click" azide-alkyne chemical...
In this paper, the internal and external cancellation phenomena for damped beams subjected to multi-moving loads are investigated in detail. To start, theory vibration of a simply supported beam is revisited by including effect damping. For first time, simple expression derived free under loads. Based on concept local minimum, two conditions identified. One cancellation, which relates inherent property conventionally known. The other newly formulated that number spacing moving comparison,...
Multiblock copolypeptides have attracted broad interests because their potential to form ordered structures and possess protein-mimetic functions. Controlled synthesis of multiblock through the sequential addition N-carboxyanhydrides (NCAs), especially with block number higher than five, however, is challenging rarely reported due competing side reactions during polymerization process. Herein, we report unprecedented up 20 blocks, enabled by ultrafast polypeptide chain propagation in a...
A series of amphiphilic diblock copolypeptides (K30 -b-F15 , K30 -b-F30 and -b-F45 ) were synthesized via N-carboxy-α-amino-anhydride ring-opening polymerization. The had excellent antibacterial efficacy to both Gram positive (S. aureus) negative (E. coli) bacteria. minimum inhibitory concentrations (MICs) against E. coli S. aureus are 8 μg mL-1 2 respectively, lower than most natural artificial antimicrobial peptides (AMPs). morphological changes the bacteria treated with investigated by...
Photo-degradable, branched poly(β-amino ester)s (BPAE-NB) were developed to mediate topology-assisted trans-membrane gene delivery as well photo-strengthened intracellular release.
The application of synthetic polypeptides is greatly limited by the difficulty purification and polymerization N-carboxyanhydrides (NCAs). Here, we report a streamlined, controlled synthesis directly from amino acids, avoiding NCA purification, adding small-molecular amine scavengers (AS) in situ to efficiently eliminate remaining organic impurities emulsion system. Such process enables PEG-containing, homo, block, random highly consistent manner under open-air condition, acid derivatives...
Based on the pH-sensitive, conformationally tunable triazole polypeptides, we reported manipulation of helix–coil transition profile determined by leveraging interactions and other side-chain helix-influencing ligands.
Ring-opening polymerization of N-carboxyanhydrides (NCAs) bearing pendant groups creates functional polypeptides. In this paper, we report the design, synthesis and tetraphenylethylene (TPE)-modified NCA, which is used to incorporate aggregation-induced emission (AIE)-active segments into Specifically, attempted amphiphilic methoxy poly(ethyleneglycol)-block-poly(γ-benzyl-l-glutamate)-block-poly(γ-4-(1,2,2-triphenylvinyl)benzyl-l-glutamate) (PEG-PBLG-PTPELG), had well-controlled molecular...
The change in the architecture of glatiramer acetate results an enhanced therapeutic effect to treat experimental autoimmune encephalomyelitis.
We controllably polymerized non-purified OEG-NCAs using a biphasic SIMPLE polymerization strategy. The resulting OEG-functionalized amphiphilic copolypeptides could self-assemble into nanoparticles.