A5101630069- Cosmology and Gravitation Theories
- Carbohydrate Chemistry and Synthesis
- Black Holes and Theoretical Physics
- Synthesis and biological activity
- Ferrocene Chemistry and Applications
- Noncommutative and Quantum Gravity Theories
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Chemical Analysis and Environmental Impact
- Nuclear Receptors and Signaling
- Advanced Photocatalysis Techniques
- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- TiO2 Photocatalysis and Solar Cells
- Proteoglycans and glycosaminoglycans research
- Allelopathy and phytotoxic interactions
- Biochemical and Molecular Research
- Crystal structures of chemical compounds
- Neuroscience and Neuropharmacology Research
- Microbial Natural Products and Biosynthesis
- Molecular spectroscopy and chirality
- Nicotinic Acetylcholine Receptors Study
- Quinazolinone synthesis and applications
- Pesticide and Herbicide Environmental Studies
Xi'an Polytechnic University
2022
University of Illinois Urbana-Champaign
2020
State Key Laboratory of Nuclear Physics and Technology
2018-2019
Peking University
2014-2019
State Key Laboratory of Natural and Biomimetic Drugs
2015
Henan Agricultural University
2012
Tianjin Medical University
2009-2011
Hong Kong Polytechnic University
2010
Nankai University
2007
Sun Yat-sen University
2007
A bstract We study the evolution of holographic subregion complexity under a thermal quench in this paper. From CV proposal AdS/CFT correspondence, CFT is holographically captured by volume codimension-one surface enclosed codimension-two extremal entanglement and boundary subregion. Under quench, dual gravitational configuration described Vaidya-AdS spacetime. In case we find that always increases at early time, after reaching maximum it decreases gets to saturation. Moreover notice when...
We explore the properties of holographic entanglement purification (EoP) for two disjoint strips in Schwarzschild-AdS black brane and Vaidya-AdS spacetimes. For given on same boundary spacetime, there is an upper bound separation beyond which EoP will always vanish no matter how wide are. In case that are boundaries spacetime respectively, we find exists only when enough. If width finite, can be nonzero a finite time region. thermal quench case, equilibrium sensitive to strips, while mutual...
Infections by intracellular pathogens are difficult to treat because of the poor accessibility antibiotics encased host cell membranes. As such, a strategy that can improve membrane permeability would significantly increase their efficiency against pathogens. Here, we report design an adaptive, metaphilic cell-penetrating polypeptide (CPP)–antibiotic conjugate (VPP-G) effectively eradicate bacteria both in vitro and vivo. VPP-G was synthesized attaching vancomycin highly membrane-penetrative...
Sialylconjugates on cell surfaces are involved in many biological events such as cellular recognition, signal transduction, and immune response. It has been reported that aberrant sialylation at the nonreducing end of glycoconjugates overexpression sialyltransferases (STs) cells correlated with malignance, invasion, metastasis tumors. Therefore, inhibitors STs would provide valuable leads for discovery antitumor drugs. On basis transition state enzyme-catalyzed reaction, we proposed...
In the new transition-state based sialyltransferase inhibitors, an amide group was placed at corresponding C-2 position of CMP-sialic acid to mimic geometry and charge distribution in transition state, simple aromatic or aliphatic rings were used instead sialic moiety. All synthetic compounds exhibited excellent α(2-6)-sialyltransferase inhibition, resulting up a 2600-fold higher affinity for enzyme than CMP-Neu5Ac, suggesting that is key element simulating features.
Uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonists with fast off-rate (UFO) may represent promising drug candidates for various neurodegenerative disorders. In this study, we report that bis(propyl)-cognitin, a novel dimeric acetylcholinesterase inhibitor and gamma-aminobutyric acid subtype A antagonist, is such an antagonist of NMDA receptors. cultured rat hippocampal neurons, demonstrated bis(propyl)-cognitin voltage-dependently, selectively, moderately inhibited NMDA-activated...
The regio- and stereo-selective construction of 2-deoxy-<italic>C</italic>-glycosides <italic>via</italic> Lewis acid-mediated rearrangement 2,3-anhydro-1-thiopyranosides is realized.
Abstract A set of novel imidazolidinedione derivatives were synthesized and evaluated as potential antidiabetic agents. Imidazolidinedione scaffold‐based molecules validated on a mice hyperglycemia model caused by alloxan. As result, three them showed antihyperglycemic activities. This research provides useful clues for further design discovery
We study quantum corrections to holographic mutual information for two disjoint spheres at a large separation by using the operator product expansion of twist field. In limit, is vanishing semiclassical order, but receive from fluctuations. show that leading contributions fluctuations take universal forms as suggested boundary CFT. find behavior scalar, vector, tensor and fermionic fields treating these free propagating in fixed background 1/n prescription. particular, with gauge symmetries,...
In title compound, C(10)H(12)O(4), all of the non-H atoms lie approximately in a plane with largest deviation being 0.061 (2) Å. An intra-molecular O-H⋯O hydrogen bond generates an S(6) ring motif. No classical inter-molecular bonding occurs, only van der Waals forces stabilizing crystal structure.
The title compound, C13H17N3O7S, is a potential AHAS (acetohydroxyacid synthase) inhibitor. In the crystal structure, nitro group twisted away from plane of aromatic ring and glutamine residue adopts folded conformation. packing stabilized by intermolecular N—H⋯O O—H⋯O hydrogen bonds.