A5107989377- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Cytomegalovirus and herpesvirus research
- Retinal Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Ophthalmology and Eye Disorders
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Neurological Disorders and Treatments
- Corneal Surgery and Treatments
- Retinal and Macular Surgery
- Otitis Media and Relapsing Polychondritis
- Myofascial pain diagnosis and treatment
- Allergic Rhinitis and Sensitization
- Opioid Use Disorder Treatment
- Herpesvirus Infections and Treatments
- Intramuscular injections and effects
- Olfactory and Sensory Function Studies
- Ocular Oncology and Treatments
- Retinal and Optic Conditions
- HIV, Drug Use, Sexual Risk
- Toxoplasma gondii Research Studies
- Gaze Tracking and Assistive Technology
Singapore National Eye Center
2013-2024
Singapore Eye Research Institute
2012-2024
Johns Hopkins University
2020
Johns Hopkins Medicine
2020
Singapore General Hospital
2017
National University of Singapore
2017
Tan Tock Seng Hospital
2013-2016
Background/Aims To identify objective criteria from optical coherence tomography (OCT) and perimetry that denote a useful, specific definition of glaucomatous optic neuropathy (GON) in eyes with open-angle glaucoma for comparisons among research studies. Methods A cross-sectional study adult patients nine centres on five continents evaluated de-identified physician diagnosis, OCT results 2580 (1531 patients) an online database. Each eye was graded by their specialist as either definite,...
Objective: The aim was to compare the visual, refractive, topographic and biomechanical outcomes in patients with progressive keratoconus treated either conventional or accelerated crosslinking at one year follow up. Methods: It is a prospective, non-randomised interventional study of 76 who underwent (CXL; 3mW/cm 2 for 30 minutes) cross linking (KXL; 30mW/cm 4 keratoconus. Baseline postoperative visual acuity, manifest refraction, corneal topography, pachymetry, endothelial cell density...
Prolonged visually stressful activities aggravate dry eye disease (DED). The duration spent on such and their relationship with DED clinical features were investigated. Patients completed an activity log as they performed usual over 1 typical rest day work day. included time in air-conditioned environment, windy driving, watching television, computer use, reading, a movie the theatre, wearing contact lens. Average daily hours calculated correlated of DED. Thirty-five logs returned. Positive...
Purpose: To analyze the clinical manifestations and treatment outcomes for patients with retinoblastoma in Singapore from 1997 to 2010. Methods: Medical records of 51 (67 eyes) diagnosed as having were analyzed. Data on laterality, genetics, presentation, disease severity, treatment, prognosis collected. Results: The mean age presentation was 25.7 ± 19.9 months. Sixteen (31.4%) had bilateral disease, whom 2 an associated pineal tumor. Leukocoria most common sign. Two metastasis at diagnosis....
Purpose: To determine the efficiency, precision, and agreement of GlauCAT-Asian its corresponding validity reliability. Methods: In this cross-sectional study, 219 participants (mean ± standard deviation age, 66.59 8.61 years; 34% female) across spectrum glaucoma severity 50 suspects were recruited from clinics in Singapore. Participants answered seven computerized adaptive testing (CAT) evaluations (Ocular Comfort, Activity Limitation, Lighting, Mobility, Concerns, Psychosocial, Glaucoma...
Chronic use of intraocular pressure-lowering medications is associated with ocular surface disease (OSD). In this study, we assess the incidence topical lubricant as a surrogate marker for underlying OSD, in medically and surgically treated glaucoma patients.Retrospective chart review was performed newly diagnosed patients who were started on 2007 followed up over 5-year period. Primary outcome measure these subset required or cataract surgery during follow-up.Charts 505 no prior history...
A glaucoma-specific health-related quality of life (HRQoL) item bank (IB) and computerized adaptive testing (CAT) system relevant to Asian populations is not currently available. We aimed develop content for an IB focusing on HRQoL domains important people with glaucoma; compare the coverage our new instrument established instruments.In this qualitative study glaucoma patients recruited from Singapore National Eye Centre (November 2018-November 2019), items/domains were generated from: (1)...
The fear of needles and pain prevents some patients from seeking intravitreal treatment, which drives our group to develop a needleless device for performing injections. A prototype an electro-magnetically actuated injector, based on Halbach arrays, is described characterized in laboratory setting. implication the ocular drug delivery investigated. This investigation intended improve glaucoma medication with safe approach. We detail design aspects injector custom-made phantoms. It was...
Abstract Introduction Respondent-driven sampling has been an effective strategy for HIV research in many settings, but had limited success among some youth the United States. We evaluated a modified RDS approach Black and Latinx sexual gender minority (BLSGMY) evaluates how lived experiences social contexts of BLSGMY may impact traditional assumptions. Methods was implemented three cities to engage prevention or care intervention trials. include targeted seed recruitment from venues,...
The data shows the aqueous humor cytokine profiling results acquired in a small cohort of 17 HIV patients clinically diagnosed with Cytomegalovirus retinitis using FlexMAP 3D (Luminex®) platform Milliplex Human Cytokine® kit. Aqueous samples were collected from these at different time points (pre-treatment and 4-weekly intervals through 12-week course intravitreal ganciclovir treatment) 41 levels analyzed each point. CMV DNA viral load was assessed 8 throughout treatment. described herein is...
A modified closure for trabeculectomy in which the conjunctiva is incised posterior to limbus and reapproximated using 2 nylon sutures, provided similar surgical outcomes standard technique.To examine of a technique burying under an anterior lip conjunctiva.This retrospective review included 73 eyes that underwent trabeculectomies between 2015 2017 at Johns Hopkins Hospital by single surgeon. We analyzed traditional closures used from January May 2016, July 2016 March 2017. The main outcome...
Purpose Chronic use of intraocular pressure (IOP) lowering medications is associated with ocular surface disease. Glaucoma surgery has also been disturbances. In this study we assess the incidence topical lubricant in glaucoma patients who are medically controlled or have had over 5 years followup. Methods Retrospective chart review was performed for on primary open angle glaucoma. Some these required subsequent surgery. Primary outcome measure and onset patients. Results 505 cases POAG were...