A5102020343- Parathyroid Disorders and Treatments
- Renal Diseases and Glomerulopathies
- Heart Failure Treatment and Management
- Mechanical Circulatory Support Devices
- Cardiac pacing and defibrillation studies
- Dialysis and Renal Disease Management
- Cannabis and Cannabinoid Research
- Muscle and Compartmental Disorders
- Hemoglobinopathies and Related Disorders
- Gut microbiota and health
- Systemic Lupus Erythematosus Research
- Clostridium difficile and Clostridium perfringens research
- Social Media in Health Education
- Connective Tissue Growth Factor Research
- Artificial Intelligence in Healthcare
- Cardiac Imaging and Diagnostics
- Erythropoietin and Anemia Treatment
- Blood properties and coagulation
- Cholesterol and Lipid Metabolism
- Hemodynamic Monitoring and Therapy
- Vasculitis and related conditions
- Genetic and Kidney Cyst Diseases
- Brain Tumor Detection and Classification
- Dermatological and Skeletal Disorders
- Nephrotoxicity and Medicinal Plants
Nanjing Medical University
2014-2024
Jiangsu Province Hospital
2014-2024
Significance Statement Activation of the type 1 IL-1 receptor (IL-1R1) triggers a critical innate immune signaling cascade that contributes to pathogenesis AKI. However, blockade in AKI has not consistently demonstrated kidney protection. The current murine experiments show IL-1R1 activation proximal tubule exacerbates toxin-induced and cell death through local suppression apolipoprotein M. By contrast, endothelial cells ameliorates by restoring VEGFA-dependent viability. Using this...
Abstract Acute kidney injury (AKI) has considerably high morbidity and mortality but we do not have proper treatment for it. There is an urgent need to develop new prevention or methods. Gut microbiota a close connection with renal diseases become the therapy target AKI. In this study, found oral administration of probiotic Limosilactobacillus reuteri had effect on AKI induced by lipopolysaccharide (LPS). It reduced serum concentration creatinine urea nitrogen protected cells from necrosis...
Uremic cardiomyopathy (UCM) is a common complication in patients with chronic kidney disease (CKD) and an important risk factor for death. P-Cresyl sulfate (PCS) damaging UCM, Klotho protective factor. However, the molecular mechanisms of PCS UCM relationship between are unclear. In vitro, treatment inhibited PCS-induced cardiomyocyte hypertrophy apoptosis by blocking mTOR phosphorylation inhibiting DNA double-strand breaks (DSBs), respectively. Moreover, increased SIRT6 protein...
Abstract Introduction The Agatston coronary artery calcification score (CACS) is an assessment index for (CAC). This study aims to explore the characteristics of CAC in end-stage kidney disease (ESKD) patients and establish a predictive model assess risk severe patients. Methods CACS ESKD was assessed using electrocardiogram-gated computed tomography (CT) scan with scoring method. A nomogram established based on stepwise regression. An independent validation cohort comprised from...
To determine the expression of miRNA-24-3p in patients with ESRD and its relationship vascular calcification. investigate possible mechanism miRNA-24-3p/sclerostin signaling pathway rat aorta smooth muscle cells calcification induced by high phosphorus.
Abstract Background : The optimal perfusion pressure target for acute kidney injury (AKI) in critically ill patients remains uncertain. We investigated the association between mean (MPP) and AKI among estimated its range. Methods analyzed data stored Medical Information Mart Intensive Care (MIMIC) -III, eICU Collaborative Research Database (eICU-CRD), MIMIC-IV databases. Critically receiving invasive measurements of MPP at least 12 hours within first 24 ICU stay were included. exposure...