A5025928093- Immune Response and Inflammation
- Immune cells in cancer
- Biochemical and Molecular Research
- SARS-CoV-2 detection and testing
- Listeria monocytogenes in Food Safety
- Salmonella and Campylobacter epidemiology
- Immune Cell Function and Interaction
- Fatty Acid Research and Health
- Preterm Birth and Chorioamnionitis
- Biosensors and Analytical Detection
- Essential Oils and Antimicrobial Activity
- Tuberculosis Research and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Reproductive Physiology in Livestock
- Pregnancy and preeclampsia studies
- Mycobacterium research and diagnosis
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- interferon and immune responses
Michigan State University
2019-2024
Pulmonary infections caused by Mycobacterium abscessus (Mab), a rapidly growing nontuberculous mycobacterium (NTM), are on the rise in patients with chronic or acquired lung disease. In contrast to immunocompetent individuals, these patient cohorts exhibit abnormal pulmonary function that result from inflammation and mucus build-up. Treatment regimens rely multi-drug cocktails yet Mab is naturally recalcitrant common antibiotics extending treatment timelines increasing frequency of failures....
The Mycobacterium tuberculosis mycolate flippase MmpL3 has been the proposed target for multiple inhibitors with diverse chemical scaffolds. This diversity in scaffolds made it difficult to predict compounds that inhibit without whole-genome sequencing of isolated resistant mutants. Here, we describe identification four new select resistance mutations mmpL3. Using these mutants, conducted a targeted whole-cell phenotypic screen 163 novel M. growth differential inhibition wild-type compared...
// Alan Halim 1 , Nasreen Al-Qadi Elizabeth Kenyon 2 Kayla N. Conner 3 4 Sujan Kumar Mondal Zdravka Medarova 5 and Anna Moore Precision Health Program, Michigan State University, East Lansing, MI 48824, USA Department of Radiology, College Human Medicine, Microbiology, Genetics, Immunology, Veterinary Diagnostic Laboratory, Transcode Therapeutics Inc., Newton, MA 02458, Correspondence to: Moore, email: moorea57@msu.edu Keywords: breast cancer; metastasis; stem-like cells; nanoparticle;...
Identification and isolation of contagious individuals along with quarantine close contacts, is critical for slowing the spread COVID-19. Large-scale testing in a surveillance or screening capacity asymptomatic carriers COVID-19 provides both data on viral follow-up ability to rapidly test during suspected outbreaks. The early detection program at Michigan State University has been utilizing large-scale since fall 2020. methods adapted here take advantage reliability, large sample volume,...
Abstract Macrophages play a crucial role in eliminating respiratory pathogens. Both pulmonary resident alveolar macrophages (AMs) and recruited contribute to detecting, responding to, resolving infections the lungs. Despite their distinct functions, it remains unclear how these macrophage subsets regulate responses infection, including activation by cytokine IFN-γ is regulated. This shortcoming prevents development of therapeutics that effectively target lung populations without exacerbating...
Alveolar macrophages (AMs) are key mediators of lung function and potential targets for therapies during respiratory infections. TGFβ is an important regulator AM differentiation maintenance, but how directly modulates the innate immune responses AMs remains unclear. This shortcoming prevents effective targeting to improve in health disease. Here we leveraged optimized
Abstract The Mycobacterium tuberculosis (Mtb) mycolic acid flippase MmpL3 has been the proposed target for multiple inhibitors with diverse chemical scaffolds. This diversity in scaffolds made it difficult to predict compounds that inhibit without whole genome sequencing of isolated resistant mutants. Here we describe identification four new select resistance mutations mmpL3. Using these mutants, conducted a targeted whole-cell phenotypic screen 163 novel Mtb growth differential inhibition...
Listeria monocytogenes (Lm) is a bacterial pathogen that causes listeriosis in immunocompromised individuals, particularly pregnant women. Several virulence factors support the intracellular lifecycle of Lm and facilitate cell-to-cell spread, allowing it to occupy multiple niches within host cross-protective barriers, including placenta. One family factors, internalins, contributes pathogenicity by inducing specific uptake conferring tissue tropism. Over 25 internalins have been identified...
ABSTRACT Macrophages play a crucial role in eliminating respiratory pathogens. Both pulmonary resident alveolar macrophages (AMs) and recruited contribute to detecting, responding to, resolving infections the lungs. Despite their distinct functions, it remains unclear how these macrophage subsets regulate responses infection, including activation by cytokine IFNγ is regulated. This shortcoming prevents development of therapeutics that effectively target lung populations without exacerbating...
Abstract Listeria monocytogenes ( Lm ) is a bacterial pathogen that causes listeriosis in immunocompromised individuals, particularly pregnant women. Several virulence factors support the intracellular lifecycle of and facilitate cell-to-cell spread, allowing it to occupy multiple niches within host cross protective barriers, including placenta. One family factors, internalins, contributes pathogenicity by inducing specific uptake conferring tissue tropism. Over 25 internalins have been...
Abstract Introduction Placental infection and inflammation are risk factors for adverse pregnancy outcomes, including preterm labor. However, the mechanisms underlying these outcomes poorly understood. Methods To study this response, we have employed a pregnant mouse model of placental caused by bacterial pathogen Listeria monocyogenes , which infects human placenta. Through in vivo bioluminescence imaging, confirm presence quantify relative levels. Infected control placentas were collected...
Identification and isolation of contagious individuals along with quarantine close contacts, is critical for slowing the spread COVID-19. Large-scale testing in a surveillance or screening capacity asymptomatic carriers COVID-19 provides both data on viral follow-up ability to rapidly test during suspected outbreaks. The early detection program at Michigan State University has been utilizing large-scale since fall 2020. methods adapted here take advantage reliability, large sample volume,...