A5084763488- Dietary Effects on Health
- SARS-CoV-2 and COVID-19 Research
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Monoclonal and Polyclonal Antibodies Research
- Infant Health and Development
- Viral gastroenteritis research and epidemiology
- Optimism, Hope, and Well-being
- Iron Metabolism and Disorders
- Poxvirus research and outbreaks
- Bacillus and Francisella bacterial research
- Herpesvirus Infections and Treatments
- Biochemical effects in animals
- Medicinal Plants and Bioactive Compounds
- Cancer-related molecular mechanisms research
Beth Israel Deaconess Medical Center
2023-2024
Harvard University
2024
Boston University
2022-2023
Abstract The SARS-CoV-2 Omicron variant has continued to evolve. XBB is a recombinant between two BA.2 sublineages, XBB.1 includes the G252V mutation, and XBB.1.5 F486P mutations. rapidly increased in frequency become dominant virus New England. bivalent mRNA vaccine boosters have been shown increase neutralizing antibody (NAb) titers multiple variants, but durability of these responses remains be determined. We assessed humoral cellular immune 30 participants who received performed assays...
Messenger RNA (mRNA) vaccines were highly effective against the ancestral SARS-CoV-2 strain, but efficacy of bivalent mRNA boosters XBB variants was substantially lower. Here, we show limited durability neutralizing antibody (NAb) responses and isotype switching to immunoglobulin G4 (IgG4) following boosting. Bivalent boosting elicited modest XBB.1-, XBB.1.5-, XBB.1.16-specific NAbs that waned rapidly within 3 months. In contrast, induced more robust sustained WA1/2020 suggesting immune...
The 2022-2023 mpox outbreak triggered vaccination efforts using smallpox vaccines that were approved for mpox, including modified vaccinia Ankara (MVA; JYNNEOS), which is a safer alternative to live replicating virus (ACAM2000). Here, we compare the immunogenicity and protective efficacy of JYNNEOS by subcutaneous or intradermal routes, ACAM2000 percutaneous route, subunit Ad35 vector-based L1R/B5R L1R/B5R/A27L/A33R intramuscular route in rhesus macaques. All provided robust protection...
Current COVID-19 vaccines provide robust protection against severe disease but minimal acquisition of infection. Intramuscularly administered induce serum neutralizing antibodies (NAbs), their ability to boost mucosal immune responses remains be determined. In this study, we show that the XBB.1.5 messenger RNA (mRNA) boosters result in increased neutralization multiple acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants humans, including dominant circulating variant JN.1....
The human gut microbiome colonizes 70% of total microorganisms in the body and its composition can be impacted by several environmental factors, particularly a high fat sugar diet called Western diet. has been extensively studied for consequential shift towards dysbiosis inflammation host other negative health outcomes including brain disorders such as Alzeihmer's Parkinson's disease. This so-called gut-brain axis may mediated key biomarkers hepcidin trimethylamine N-oxide (TMAO). In setting...
An increase in chronic proinflammatory immune activity is recognized as an increasingly fundamental element relation to neurodegenerative disorders. Alzheimer's disease (AD) one of the most common disorders, with recent evidence suggesting Western Diet a source for systemic inflammation. The communication fusing gut brain axis has been investigated through hepcidin, derived from both hepatocytes and dendritic cells. Hepcidin could potentially play anti-inflammatory role process dysbiosis...