A5069986207- Lipid Membrane Structure and Behavior
- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Surfactants and Colloidal Systems
- Nanoplatforms for cancer theranostics
- Proteins in Food Systems
- RNA Interference and Gene Delivery
- Polymer Surface Interaction Studies
- Glycosylation and Glycoproteins Research
- Supramolecular Self-Assembly in Materials
- Microfluidic and Capillary Electrophoresis Applications
- Force Microscopy Techniques and Applications
- Polysaccharides Composition and Applications
- Nanoparticle-Based Drug Delivery
- Pickering emulsions and particle stabilization
- Molecular Junctions and Nanostructures
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Carbohydrate Chemistry and Synthesis
- Analytical Chemistry and Chromatography
- Advanced Drug Delivery Systems
- Microencapsulation and Drying Processes
- Hydrogels: synthesis, properties, applications
- Surface Modification and Superhydrophobicity
- Drug Solubulity and Delivery Systems
Centre National de la Recherche Scientifique
2015-2024
Université Paris-Saclay
2015-2024
Université d'Orléans
2023-2024
Institut Galien Paris-Saclay
2013-2022
Université Paris-Sud
2010-2019
Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
2008-2019
Laboratoire de Physico-Chimie de l'Atmosphère
2013
Université Toulouse III - Paul Sabatier
2012
Laboratoire de Chimie Physique
2003-2011
University of Turin
2006
Nucleoside analogues display significant anticancer or antiviral activity by interfering with DNA synthesis. However, there are some serious restrictions to their use, including rapid metabolism and the induction of resistance. We have discovered that linkage nucleoside squalene leads amphiphilic molecules self-organize in water as nanoassemblies 100−300 nm, irrespective analogue used. The squalenoyl gemcitabine exhibited superior vitro human cancer cells gemcitabine-resistant murine...
Abstract Background Porphyrin-lipids are versatile building blocks that enable cancer theranostics and have been applied to create several multimodal nanoparticle platforms, including liposome-like porphysome (aqueous-core), porphyrin nanodroplet (liquefied gas-core), ultrasmall lipoproteins. Here, we used porphyrin-lipid stabilize the water/oil interface nanoemulsions with paclitaxel loaded in oil core (PLNE-PTX), facilitating combination photodynamic therapy (PDT) chemotherapy one...
Two glycodendrimeric phenylporphyrins were synthesized and their interaction with phospholipids was studied at the air-water interface in liposome bilayers; such liposomes bearing porphyrin could constitute an efficient carrier for drug targeting photodynamic therapy.
Scope Vitamin E is present in feed and food mainly as d‐α‐tocopherol (d‐α‐ TOL ) but also all‐ rac ‐α‐tocopheryl acetate ( ‐α‐ TAC through supplementation. Its absorption efficiency low compared to that of triacylglycerols. The aim this work was thus study the fate during digestion. Methods results Using an vitro digestion model, we showed distributed between mixed micelles (36%), liposomes (9%), nonsolubilized debris (52%). A significant fraction found emulsions when fat hydrolysis not...
1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), a lipid comprising saturated and an unsaturated acyl chain, belongs to the class of glycerophosphatidylcholines, major lipids in eukaryotic cell membranes. To get insight into structural properties this within monolayers as membrane models, we performed molecular dynamics (MD) simulations POPC under compression at air/water interface. MD were carried out 300 K different surface pressures using all-atom general Amber force field (GAFF)....
Pickering emulsions were formulated using biodegradable and biocompatible poly(lactic- co-glycolic acid) (PLGA) nanoparticles (NPs) prepared without surfactants or any other polymer than PLGA. A pharmaceutical cosmetic oil (Miglyol) was chosen as the phase at a ratio of 10% w/w. These then compared with same but well-described PLGA-poly(vinyl alcohol) (PVA) NPs, i.e., PVA NP stabilizers. Strikingly, demonstrated very different structures macroscopic, microscopic, interfacial scales,...
Adsorption of glucose oxidase (GOx) at the solution/air interface in presence and absence spread monolayers dibehenoylphosphatidylcholine (DBPC) has been monitored by surface tension potential measurements. At monolayer-free solution concentration levels enzyme higher than 4 μg/mL, this adsorption was found to be time dependent. Below threshold value, no decrease could observed. Conversely, monolayers, increments pressure were recorded even GOx concentrations which diminution These decreased...
We modulate precisely the surface morphology of polymer microcapsules containing perfluorooctyl bromide prepared by solvent-evaporation technique varying percentage PLGA-PEG copolymer in formulation. As increases, protrusions start to appear, become more numerous and finally fuse yield sponge-like capsules. It has been postulated that shell arises from an interfacial tension instability. show here if instability develops, it happens during final step desolvation, when interface is no longer...
In this paper, we discuss the evolution over last 15 years in Curie Institute of concept, development design and some properties glycoconjugated photosensitizers with aim to optimize tumor targeting photodynamic therapy. By research, have shown that specific interactions between a mannose-lectin trimannosylglycodendrimeric porphyrins contributed larger extent than non-specific ones overall interaction glycosylated tetraarylporphyrin membrane. The studies vitro photocytotoxicity showed...
Squalene-based nucleolipids, including anticancer or antiviral prodrugs, gave rise to nanoparticles displaying a diversity of structures upon nanoprecipitation in water. Synchrotron small-angle X-ray scattering and cryo-TEM imaging revealed that both the nature nucleoside position squalene moiety relative nucleobase determined self-assembly corresponding bioconjugates. It was found small chemical differences resulted major self-organization nucleolipids when grafted onto whereas only...
The outer membrane (OM) of Gram-negative bacteria is a complex and asymmetric bilayer that antimicrobial peptides must disrupt in order to provoke the cell lysis. inner external leaflets OM are mainly composed phospholipids (PL), lipopolysaccharide (LPS), respectively. Supported lipid bilayers interesting model systems mimic scaffold determine quantitative mechanistic effect agents, using complementary physicochemical techniques. We report formation PL/LPS Langmuir-Blodgett/Langmuir-Schaefer...
Gemcitabine (dFdC or Gem) is a water-soluble cytotoxic drug, with poor cellular uptake in the absence of nucleoside transporter. To improve its diffusion through membranes, it was modified by grafting squalenoyl moiety. In water, this derivative able to form stable and monodispersed nanoparticles made inverse hexagonal phases. The formation interfacial properties gemcitabine (SQ-Gem) nanoparticles, their ability interact phospholipid cholesterol monolayers modeling biomembrane, assessed from...