A5103099876- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Lipid Membrane Structure and Behavior
- Nanoplatforms for cancer theranostics
- Molecular Junctions and Nanostructures
- Force Microscopy Techniques and Applications
- Antimicrobial Peptides and Activities
- Glycosylation and Glycoproteins Research
- Surfactants and Colloidal Systems
- Photonic Crystals and Applications
- Radiation Effects and Dosimetry
- Surface Chemistry and Catalysis
- Nanoparticle-Based Drug Delivery
- Food Quality and Safety Studies
- Mycotoxins in Agriculture and Food
- RNA Interference and Gene Delivery
- Photosynthetic Processes and Mechanisms
- Liquid Crystal Research Advancements
- Bacteriophages and microbial interactions
- Antifungal resistance and susceptibility
- Semiconductor materials and devices
- Plant Virus Research Studies
- Toxin Mechanisms and Immunotoxins
- Pickering emulsions and particle stabilization
- Protein Interaction Studies and Fluorescence Analysis
Centre National de la Recherche Scientifique
2013-2024
Université Paris-Saclay
2016-2024
Université d'Orléans
2023-2024
Institut Galien Paris-Saclay
2008-2021
Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
2008-2020
Université Paris-Sud
2008-2019
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
1972-2013
Université Toulouse III - Paul Sabatier
2012
Center for Research in Psychopathology and Clinical Psychology
2007
Paul Pascal Research Center
2007
We established tightly controlled experimental conditions to synthesize polydopamine nanoparticles with well-defined and reproducible physicochemical properties such as size, yield nanomechanics.
Two libraries of well-defined, degradable vinyl copolymers opposite solubility, based either on methyl methacrylate (MMA) or oligo(ethylene glycol) ether (OEGMA), and containing various amount 2-methylene-4-phenyl-1,3-dioxolane (MPDL), were synthesized by nitroxide-mediated radical ring-opening polymerization. A comprehensive degradation study (long-term hydrolytic degradation, thick thin films, water uptake, enzymatic degradation) was then performed, results compared with those from...
Two glycodendrimeric phenylporphyrins were synthesized and their interaction with phospholipids was studied at the air-water interface in liposome bilayers; such liposomes bearing porphyrin could constitute an efficient carrier for drug targeting photodynamic therapy.
Inhibition of fungal growth by Congo red (CR) has been putatively associated with specific binding to β-1,3-glucans, which blocks cell wall polysaccharide synthesis. In this study, we searched for transcription factors (TFs) that regulate the response CR and interrogated their regulon. During investigation susceptibility TF mutant library, several CR-resistant -hypersensitive mutants were discovered further studied. Abnormal distorted swollen conidia called Quasimodo cells seen in presence...
In this paper, we discuss the evolution over last 15 years in Curie Institute of concept, development design and some properties glycoconjugated photosensitizers with aim to optimize tumor targeting photodynamic therapy. By research, have shown that specific interactions between a mannose-lectin trimannosylglycodendrimeric porphyrins contributed larger extent than non-specific ones overall interaction glycosylated tetraarylporphyrin membrane. The studies vitro photocytotoxicity showed...
The outer membrane (OM) of Gram-negative bacteria is a complex and asymmetric bilayer that antimicrobial peptides must disrupt in order to provoke the cell lysis. inner external leaflets OM are mainly composed phospholipids (PL), lipopolysaccharide (LPS), respectively. Supported lipid bilayers interesting model systems mimic scaffold determine quantitative mechanistic effect agents, using complementary physicochemical techniques. We report formation PL/LPS Langmuir-Blodgett/Langmuir-Schaefer...
If the mycelium of Aspergillus fumigatus is very short-lived in laboratory, conidia can survive for years. This survival capacity and extreme resistance to environmental insults a major biological characteristic this fungal species. Moreover, conidia, which easily reach host alveola, are infective propagules. Earlier studies have shown role some molecules outer conidial layer protecting fungus against defense. The cell wall, directly contact with cells, consists α-(1,3)-glucan, melanin,...
Abstract Polydopamine (PDA) is a mussel-inspired and melanin-mimicking material that has attracted considerable attention during the recent years. This ‘polymer’ displays diverse promising properties, like its simple preparation procedures, easy functionalization, free radicals scavenging activity, outstanding photothermal photoacoustic performance, great biocompatibility biodegradability. A remarkable feature of PDA ability to form colloidal nanosized particles or nanoscaled coatings,...
Metal deposition on silicon from HF‐based solutions is initiated by electrochemical reduction of metal ions, a process which driven the difference between electron quasi Fermi energy in silicon, EFn, and redox level ions solution, . Mechanisms for ion are elucidated aligning bands with levels solution. For copper, reaction occurs capture conduction band electrons, requires nucleation nanometer‐sized precipitates surface. As concentration electrons at surface, ns, increased (e.g., n‐type...
In photodynamic therapy, the specificity of a photosensitizer and its penetration into tumor cells are crucial. We have analyzed ability newly synthesized meso-(tetraphenyl)porphyrins to be recognized by model mannose-specific proteins overexpressed at surface retinoblastoma cells. The specific interaction porphyrin with Con A was studied pressure measurements, fluorescence spectroscopy, dynamic light scattering, QCM-D. extent porphyrins binding highly dependent upon their chemical...
Photodynamic therapy (PDT) is considered one efficient treatment against retinoblastoma. The specificity of a photosensitizer and its penetration into cancerous cells are crucial for achieving tumor necrosis. selection photosensitizers such as porphyrin derivatives by thus depends to large extent on their ability interact with the biological membrane. In this work, we have studied surface pressure measurements fluorescence spectroscopy interaction between three newly synthesized dendrimeric...
We study ultrathin films of 8CB in planar anchoring on a MoS2 inorganic substrate. evidence an breakage for 60-nm-thick films, favor the homeotropic at air interface. This allows one to determine 8CB-MoS2 smectic energy. then demonstrate thinner than 60 nm that, under bulk, intermediate film remains anchoring, associated with melting layers close Such could be general or tilted anchorings and we show strong anchorings, energy can driven by deformations this nematic film.
Abstract The radiodepolymerization of starch is studied by means investigating the variations intrinsic viscosity and rate water‐soluble products. experimental results corroborate theoretical laws proposed in an earlier paper. Special study watersoluble products shows how can be used to investigate chemical functions radioinduced on chains dextrins.
The development of elongated nanoparticles for drug delivery is growing interest in recent years, due to longer blood circulation and improved efficacy compared spherical counterparts. Squalenoyl-doxorubicin (SQ-Dox) conjugate was previously shown form with therapeutic decreased toxicity free doxorubicin. By using experimental computational techniques, we demonstrate here that the specific physical properties SQ-Dox, which include stacking electrostatic interactions doxorubicin as well...
Abstract Studies of the Formation Processes Some Identified Radiolysis Products after Gamma Irradiation Maize Starch . From variations in concentrations different starch radiolysis products, studied as function water content and oxygen pressure, it has been possible to suggest formation processes. The initied break COC linkages well further rearrangement radicals formed or their reactions with explain observed rearrangements. Water generally a protector effect, which can be interpreted an...
Abstract A theoretical study of the depolymerization starch under action gamma radiation is proposed: it allows prediction variations average degree polymerization and mass water‐soluble products sample as a function parameters treatment characteristics starch.