A5031764943- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Dendrimers and Hyperbranched Polymers
- Nanoparticle-Based Drug Delivery
- Antimicrobial agents and applications
- Polymer Surface Interaction Studies
- Graphene and Nanomaterials Applications
- Chemical Synthesis and Reactions
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Luminescence and Fluorescent Materials
- Lanthanide and Transition Metal Complexes
- Orthopaedic implants and arthroplasty
- Nanoplatforms for cancer theranostics
- Polymer composites and self-healing
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Photopolymerization techniques and applications
- Radioactive element chemistry and processing
- Polyoxometalates: Synthesis and Applications
MedinCell (France)
2023
Centre National de la Recherche Scientifique
2015-2019
Institut Galien Paris-Saclay
2015-2019
Centro de Investigacion Principe Felipe
2019
Centro Médico Sanitas Valencia
2019
Université Paris-Sud
2015-2018
Pharmac
2015-2018
Laboratoire d'Énergétique Moléculaire et Macroscopique, Combustion
2015-2018
Radical copolymerization of donor-acceptor (D-A) monomer pairs has served as a versatile platform for the development alternating copolymers. However, due to use conventional radical polymerization, resulting copolymers have generally been limited nondegradable vinyl polymers. By combining D-A with ring-opening polymerization (rROP), we synthesized an copolymer high incorporation degradable backbone units. Copolymerization N-ethyl maleimide (NEtMI) cyclic ketene acetal (CKA)...
Radical ring-opening copolymerization-induced self-assembly (rROPISA) was performed by copolymerizing benzyl methacrylate and cyclic ketene acetals (CKA), such as 2-methylene-4-phenyl-1,3-dioxolane or 5,6-benzo-2-methylene-1,3-dioxepane, in heptane at 90 °C reversible addition-fragmentation chain transfer (RAFT) polymerization from a poly(lauryl methacrylate) macro-RAFT agent. The lengths of both the solvophilic agent solvophobic block, together with initial amount CKA, were independently...
The review focus on branched polymers as promising delivery systems with immunomodulatory properties against cancer and infectious diseases. It covers their physicochemical how those can be tailored to modulate the immune system.
The efficient and reliable synthesis of 2-methylene-4-phenyl-1,3-dioxolane (MPDL) was reported MPDL used as a controlling comonomer for nitroxide-mediated polymerization methyl methacrylate to give degradable copolymers.
Polymer prodrug nanoparticles with aggregation-induced emission properties were readily prepared by a “grafting from” approach, leading to excellent imaging ability and cytotoxicity cancer cells.
Two libraries of well-defined, degradable vinyl copolymers opposite solubility, based either on methyl methacrylate (MMA) or oligo(ethylene glycol) ether (OEGMA), and containing various amount 2-methylene-4-phenyl-1,3-dioxolane (MPDL), were synthesized by nitroxide-mediated radical ring-opening polymerization. A comprehensive degradation study (long-term hydrolytic degradation, thick thin films, water uptake, enzymatic degradation) was then performed, results compared with those from...
2 Methylene-4-phenyl-1,3-dioxolane (MPDL) was used as a controlling comonomer in NMP with oligo(ethylene glycol) methyl ether methacrylate (MeOEGMA) to prepare well-defined and degradable PEG-based P(MeOEGMA-<italic>co</italic>-MPDL) copolymers.
Degradable polymer prodrugs were synthesized by ‘drug-initiated’ nitroxide-mediated radical ring-opening copolymerization and led to either nanoparticles or soluble with adjustable cytotoxicity on two different cancer cell lines.
Polymer prodrugs based on cladribine (CdA) as an anticancer drug have been prepared by growing short, well-defined polyisoprene (PI) chains (with number-average molar mass = 1420–4980 g mol–1 and dispersity 1.09–1.20) from CdA-bearing alkoxyamine nitroxide-mediated polymerization. Nanoparticles were formed nanoprecipitation into water of the resulting CdA-PI conjugates exhibited long-term colloidal stability in different media, tunable characteristics, release profiles, activities vitro,...
Facile derivatization of paclitaxel (Ptx) and subsequent “drug-initiated” synthesis well-defined Ptx-polymer prodrugs was performed from nitroxide-mediated polymerization or reversible addition–fragmentation chain transfer polymerization.
Investigation on the reactivity and controlling ability of a series amide-functionalized alkoxyamines based SG1 nitroxide is reported.
Front Cover: Nitroxide-mediated polymerization (NMP) of methacrylic esters is still a great challenge in the field polymer science. This Feature Article will first discuss reasons why this class monomers–the most representative one being methyl methacrylate–is usually poorly controlled by NMP, and then present successful strategies to control their polymerization. NMP-derived materials comprising uncontrolled methacrylate segments also be covered. Further details can found article E....