A5079047432- Sulfur Compounds in Biology
- Neuroscience and Neuropharmacology Research
- Glaucoma and retinal disorders
- Amino Acid Enzymes and Metabolism
- Biochemical effects in animals
- Neuroscience of respiration and sleep
- Receptor Mechanisms and Signaling
- Nitric Oxide and Endothelin Effects
- Retinal Development and Disorders
- Eicosanoids and Hypertension Pharmacology
- Connexins and lens biology
- Nicotinic Acetylcholine Receptors Study
- Antioxidant Activity and Oxidative Stress
- Retinoids in leukemia and cellular processes
- Redox biology and oxidative stress
- Neurotransmitter Receptor Influence on Behavior
- Mast cells and histamine
- Free Radicals and Antioxidants
- Cannabis and Cannabinoid Research
- Neurological Disorders and Treatments
- Inflammatory mediators and NSAID effects
- Neuropeptides and Animal Physiology
- Advanced Glycation End Products research
- Molecular Sensors and Ion Detection
- Traditional and Medicinal Uses of Annonaceae
Texas Southern University
2016-2025
Creighton University
1996-2019
University of Houston
2003-2008
CHI Health Creighton University Medical Center - Bergan Mercy
2004
Langston University
2003
University of Louisville
1990-1993
Smith-Kettlewell Eye Research Institute
1990-1993
Both hydrogen sulfide and endocannabinoids can protect the neural retina from toxic insults under in vitro vivo conditions. Purpose: The aim of present study was two-fold: (a) to examine neuroprotective action cannabinoids [methanandamide 2-arachidonyl glycerol (2-AG)] against peroxide (H2O2)-induced oxidative damage isolated bovine (b) evaluate role endogenously biosynthesized (H2S) inhibitory actions on stress retina. Methods: Isolated retinas cows were exposed using H2O2 (100 µM) for 10...
In this study, we investigated the effect of a slow-releasing hydrogen sulfide (H2S) donor, GYY 4137, on intraocular pressure (IOP) in normotensive rabbits. Furthermore, compared IOP-lowering action 4137 with those elicited by other H2S-producing compounds, l-cysteine and ACS67 (a hybrid compound latanoprost an H2S-releasing moiety).IOP was measured New Zealand male albino rabbits using pneumatonometer (model 30 classic; Reichert Ophthalmic Instruments, Depew, NY). At 0 h, 50 μL test...
Both naturally occurring and synthetic prostaglandins (PGs) caused concentration-dependent inhibition of electrically evoked [3H]norepinephrine (NE) overflow from the isolated, superfused rabbit iris-ciliary body without affecting basal tritium efflux. The rank order potencies agonists was: sulprostone greater than 16, 16-dimethyl-PGE2 PGE2 11-deoxy-PGE1 iloprost (stable PGl2 analog) PGF2 alpha or equal to PGD2. However, Tx-mimetic, U-46619, was effect on transmitter release at...
We have evidence that hydrogen sulfide (H
Prostaglandins (PGs) of the E series have been shown to modulate sympathetic neurotransmitter release in a variety peripheral tissues and organs, including eye. In this study, we evaluated inhibitory effects naturally-occurring synthetic PGs on field stimulation-evoked 3H-norepinephrine (3H-NE) from isolated, superfused segments human iris-ciliary body. Field-stimulated 3H-NE secretion was calcium-dependent, blocked by selective inhibitors voltage-sensitive calcium sodium channels,...