A5083383817- Effects and risks of endocrine disrupting chemicals
- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- Endometriosis Research and Treatment
- Neonatal Respiratory Health Research
- Vitamin D Research Studies
- Infant Nutrition and Health
- Uterine Myomas and Treatments
- Animal testing and alternatives
- Preterm Birth and Chorioamnionitis
- Cancer Risks and Factors
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
Michigan State University
2023
Wake Forest University
2019
The Ohio State University
2019
University of Cincinnati Medical Center
2012-2018
University of Cincinnati
2015-2017
Endometriosis is a gynecological disease affecting 1 in 10 women of reproductive age. incidence has risen; however, whether this rise due to awareness or environmental contamination not known.
Bisphenol A (BPA) is an endocrine disrupting chemical that ubiquitous in wild and built environments. Due to variability study design, the disruptive effects of BPA have proven difficult experimentally replicate. This was designed assess actions dietary exposure, while carefully controlling for known confounders. Parental CD1 mice were acclimated defined diet containing (0.03, 0.3, 3, 30, or 300 ppm) 17α-ethinyl estradiol (EE; 0.0001, 0.001, 0.01 bred produce progeny (F1) maintained through...
Abstract Background Information is limited regarding the prevalence and importance of hepatic histologic abnormalities in dogs with gallbladder mucocele (GBM). Objectives To (a) report GBM (b) evaluate for association between outcome (c) whether neutrophil‐to‐lymphocyte ratio (NLR) differs without specific lesions. Animals Fifty‐two grossly histologically confirmed GBM. Methods Multicenter, retrospective study undergoing cholecystectomy concurrent liver biopsy. Archived histological sections...
Abstract The goal of this study was to determine whether bisphenol A (BPA) had adverse effects indicative cardiac toxicity. As part the “ Consortium Linking Academic and Regulatory Insights on BPA Toxicity ” (CLARITY-BPA), dams offspring were exposed by daily gavage five doses ranging from 2.5 25000 μg/kg/day, 0.05 or 0.5 μg/kg/day 17α-ethinyl-estradiol (EE) 0.3% carboxymethylcellulose vehicle. Exposure-related analyzed in isolated hearts quantitative morphometry histopathology. No...
Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) with known estrogenic activity. Exposure to BPA in adult mice was shown previously increase uterine pathology associated alterations the immune response and fibrosis. Reported here are histopathology findings from CD1 exposed or 17α-ethinyl estradiol at multiple doses conception through postnatal day 90. Along pathology, impacts of exposure on collagen accumulation F4/80 positive macrophage numbers, as indicator endometrium...
Abstract Amniotic fluid was collected from pregnant female African green monkeys (n = 20). Analyses indicate microbial translocation into amniotic during pregnancy is typical, and load reduces across gestation. Microbial does not relate to infant outcome or maternal factors. Lastly, we demonstrate that sample contamination easily introduced detectable.