A5035803665- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Infectious Diseases and Mycology
- Child Nutrition and Water Access
- Liver physiology and pathology
- Veterinary Oncology Research
- Malaria Research and Control
- Medical and Biological Ozone Research
- Hydrogen's biological and therapeutic effects
- Digestive system and related health
- Laser Applications in Dentistry and Medicine
- Pharmacological Effects and Toxicity Studies
- Travel-related health issues
- Pediatric Hepatobiliary Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Hepatitis C virus research
- Infant Nutrition and Health
- Pancreatitis Pathology and Treatment
- Mast cells and histamine
Shanghai Changzheng Hospital
2009-2023
Purdue University West Lafayette
2023
Michigan State University
2022
Johns Hopkins Medicine
2019
Johns Hopkins University
2019
Second Military Medical University
2009-2015
Background & AimsNecrotizing enterocolitis (NEC) is a devastating disease of premature infants characterized by Toll-like receptor 4 (TLR4)-dependent intestinal inflammation and enterocyte death. Given that necroptosis proinflammatory cell death process linked to bacterial signaling, we investigated its potential role in NEC, the mechanisms involved.MethodsHuman mouse NEC intestine were analyzed for gene expression (ie, RIPK1, RIPK3, MLKL), protein activation (phosphorylated RIPK3). To...
Wound infections with antibiotic-resistant bacteria, particularly the Gram-negative strains, pose a substantial health risk for patients limited treatment options. Recently topical administration of gaseous ozone and its combination antibiotics through portable systems has been demonstrated to be promising approach eradicate commonly found strains bacteria in wound infections. However, despite significant impact treating growing number infections, uncontrolled high concentrations can cause...
The prognostic significance of internal tandem duplication (ITD) mutations in exons 8 and 11 c-kit has been well-described for canine cutaneous mast cell tumors (MCTs), but have rarely reported subcutaneous MCTs. objective this study was to identify the prevalence ITD MCTs investigate its association with histologic grade, KIT pattern, proliferation markers. c-kit, mitotic count, Ki67 index, AgNOR number, Ki67xAgNOR score, grade (two-tier system) were retrospectively recorded 216 dogs...
Objective To evaluate the efficacy, safety and tolerability of different doses rifaximin in Chinese patients with liver cirrhosis. Methods This random prospective study included a screening visit, 2‐week treatment period subsequent 4‐week observation phase. Patients cirrhosis were randomly assigned to low‐dose group, high‐dose group control ratio 1:1:1. The groups received 400 mg or 600 per 12 h for 2 weeks, respectively. All other therapeutic strategies remained unchanged three as long...
To analyze drug-induced liver disease over an 8-year period from January 2000 to December 2007 in one gastroenterological department.International consensus of standard definitions and criteria for assessing causality adverse drug reactions were applied all patients with abnormal hepatic test results.Drugs implicated injury 30 (15 men 15 women) whom there was a causal or highly probable relationship between use disease. The drugs responsible damage Chinese medicinal herbs (n = 12),...
Abstract Background Information is limited regarding the prevalence and importance of hepatic histologic abnormalities in dogs with gallbladder mucocele (GBM). Objectives To (a) report GBM (b) evaluate for association between outcome (c) whether neutrophil‐to‐lymphocyte ratio (NLR) differs without specific lesions. Animals Fifty‐two grossly histologically confirmed GBM. Methods Multicenter, retrospective study undergoing cholecystectomy concurrent liver biopsy. Archived histological sections...
The aim of this study was to determine whether cirrhosis could be reversed after treated with hepatocyte nuclear factor 4α (HNF4α), a key transcriptional regulator differentiation and function.Early advanced stages liver were induced by thioacetamide (TAA) administration. adenovirus carrying HNF4α gene injected into cirrhotic rats via the tail vein. effect on evaluated histological immunohistochemical examination.Early stage remarkably resolved nearly-normal extent partially ameliorated in...
OBJECTIVE: The relationship between serum viremia and the development of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)‐related cirrhosis remains unclear. We aimed at calculating odds ratios ( OR ) for presence HCC over a range HBV DNA levels these patients. METHODS: Patients were identified retrospectively 155 pairs matched, treatment‐naive HBV‐related cirrhotic without recruited. Their measured diagnosis, or equivalent age non‐HCC patients, correlations different...
Objectives Covert hepatic encephalopathy (CHE) negatively affects the health‐related quality of life and increases risk overt HE (OHE) in patients with liver cirrhosis. However, impact CHE on long‐term patient outcomes remains controversial. This study aimed to explore association between disease progression survival among cirrhotic patients. Methods was a single‐center prospective that enrolled 132 hospitalized cirrhosis, an average follow‐up period 45.02 ± 23.06 months. diagnosed using...