A5021018013- Plant Genetic and Mutation Studies
- DNA Repair Mechanisms
- 3D Printing in Biomedical Research
- Pancreatic function and diabetes
- Pluripotent Stem Cells Research
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Nuts composition and effects
- Peanut Plant Research Studies
- Trace Elements in Health
- Advanced biosensing and bioanalysis techniques
- Cancer Cells and Metastasis
- Adipose Tissue and Metabolism
- Hydrogen's biological and therapeutic effects
- Bone health and treatments
- NF-κB Signaling Pathways
- Neurotransmitter Receptor Influence on Behavior
- Biopolymer Synthesis and Applications
- Cell death mechanisms and regulation
- FOXO transcription factor regulation
- Cancer Genomics and Diagnostics
Eskişehir Osmangazi University
2022-2024
Stem Cell Institute
2024
Abstract Targeting lung cancer stem cells (LC-SCs) for metastasis may be an effective strategy against cancer. This study is the first on epithelial-mesenchymal transition (EMT) properties of boric acid (BA) in LC-SCs. LC-SCs were isolated using magnetic cell sorting (MACS) method. Tumor-sphere formation and flow cytometry confirmed CSC phenotype. The cytotoxic effect BA was measured by MTT analysis, EMT examined migration analysis. expression levels ZEB1, SNAIL1, ITGA5, CDH1, ITGB1, VIM,...
DNA double-strand break (DSB) repair genes interact with tumor stemness- and resistance-associated processes in cancer stem cells (CSCs). Therefore, targeting DSB treatment is important for the CSC phenotype. Although anti-cancer effect of boric acid (BA) has been studied, its on unclear. Moreover, no studies investigate BA's effects lung (LC-SCs). To fill gap, we aimed to assess BA A549 cells. CSCs were isolated from human non-small cell (A549) characterized by flow cytometry. Different...
Abstract Due to their high expression profile of multi‐drug resistance genes, cancer stem cells (CSCs) are the main source drug resistance. The aim this study was establish a gemcitabine‐hydrochloride‐resistant (rt) human non‐small cell lung (hNSCLC) line and CSC be used as disease models in various studies. In first phase study, gemcitabine hydrochloride‐rt hNSCLC produced by making them rt through periodic exposure hydrochloride. This acquired gemcitabine‐hydrochloride‐rt characterized for...