A5067205986- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Extracellular vesicles in disease
- Ultrasound and Hyperthermia Applications
- Radiation Therapy and Dosimetry
- Perovskite Materials and Applications
- Photoacoustic and Ultrasonic Imaging
Union Hospital
2018-2024
Jilin University
2018-2024
Union Hospital
2018-2023
Currently, multifunctional nanotechnology is strongly expected to improve the prospect of treatment and diagnosis. In this study, we synthesized epidermal growth factor (EGFR)-targeted phase-changeable polymer nanoparticles (C-HPNs) loaded with two drugs (C225 10-HCPT) for specific tumor targeting, synergistic chemotherapy, ultrasound imaging under low-intensity focused (LIFU). Cetuximab (C225), an EGFR-targeted monoclonal antibody, was conjugated on surface nanoparticles, leading a...
The advantages of PCM@Lip/IT NPs include mitochondrial-targeting, on-demand drug release, and prodrug activation by hypoxia with guidance/monitoring PA FL imaging.
Sonodynamic therapy (SDT), with its high tissue penetration and noninvasive advantages, represents an emerging approach to eradicating solid tumors. However, the outcomes of SDT are typically hampered by low oxygen content immunosuppression in tumor microenvironment (TME). Accordingly, we constructed a cascade nanoplatform regulate TME improve anti-tumor efficiency SDT.In this study, rationally design incorporating immunostimulant hyaluronic acid (HA) sonosensitizer chlorin e6 (Ce6) on...
In order to diagnose and treat papillary thyroid carcinoma (PTC) accurately, phase-transition nanoparticles, P@IP-miRNA (PFP@IR780/PLGA-bPEI-miRNA338-3p), was engineered. The nanoparticles (NPs) can target the tumor cells, realize multimodal imaging, provide sonodynamic-gene therapy for PTC.P@IP-miRNA NPs were synthesized through double emulsification method, miRNA338-3p attached surface of by electrostatic adsorption. characterization detected screen out qualified nanoparticles. vitro,...
The effective accumulation of nanoparticles (NPs) in the tumour area is an important goals current nanotechnology research, and a targeted nanoplatform solution. So we designed multifunctional sound-sensitive NP that combines sonosensitizer to enable precisely targeted, deep-penetration sonodynamic therapy (SDT) combination with multimodal imaging for diagnosis monitoring renal cell carcinoma (RCC).