A5070702694- Platelet Disorders and Treatments
- Blood groups and transfusion
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Autoimmune Bullous Skin Diseases
- Complement system in diseases
- Healthcare cost, quality, practices
- Cardiovascular and exercise physiology
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Chronic Lymphocytic Leukemia Research
- Central Venous Catheters and Hemodialysis
- Renal Diseases and Glomerulopathies
- Kawasaki Disease and Coronary Complications
- Dementia and Cognitive Impairment Research
- Aging, Elder Care, and Social Issues
- Cardiovascular Effects of Exercise
- Coronary Artery Anomalies
- Amyotrophic Lateral Sclerosis Research
- Blood disorders and treatments
- Intergenerational Family Dynamics and Caregiving
- Mechanical Circulatory Support Devices
- Hemoglobinopathies and Related Disorders
- Cardiovascular Function and Risk Factors
- Blood donation and transfusion practices
West Suffolk NHS Foundation Trust
2022
Cambridge University Hospitals NHS Foundation Trust
2019-2020
Papworth Hospital NHS Foundation Trust
2014
Cardiff Metropolitan University
2012
Newcastle University
2009
Patients with COVID-19 have a coagulopathy and high thrombotic risk. In cohort of 69 intensive care unit (ICU) patients we investigated for evidence heparin resistance in those that received therapeutic anticoagulation. 15 the anticoagulation either unfractionated (UFH) or low molecular weight (LMWH), which full information was available on 14 patients. Heparin to UFH documented 8/10 (80%) sub-optimal peak anti-Xa following LMWH 5/5 (100%) where this measured (some both anticoagulants...
Individuals with high aerobic fitness have lower systolic left ventricular strain, rotation and twist (‘left (LV) mechanics’) at rest, suggesting a beneficial reduction in LV myofibre stress more efficient function. However, the mechanisms responsible for this functional adaptation are not known influence of on mechanics during dynamic exercise has never been studied. We assessed mechanics, wall thickness dimensions, central augmentation index (AIx), aortic pulse wave velocity (aPWV), blood...
Acute thrombotic thrombocytopenic purpura (TTP) is a life-threatening emergency and plasma exchange (PEX) the initial treatment shown to reduce acute mortality.To compare current practice in United Kingdom (UK) against standards set out 2012 British Society of Haematology guideline, better understand issues affecting prompt initiation PEX.The trainee research network HaemSTAR conducted retrospective nationwide review adults presenting UK hospitals with first episode TTP.Data on 148 patients...
Intravenous immunoglobulin (IVIg) is a common therapy for patients with immune thrombocytopenia (ITP). The initial response rate IVIg 80%[1][1] and typically rapid, some responding in 24 hours, although usually 2–4 days.[2][2] When used alone, the
A 35-year-old woman presented with a widespread petechial rash and pancytopenia. She underwent simultaneous pancreas kidney transplantation for type 1 diabetes 8 years previously followed by renal transplant year prior to presentation, was taking tacrolimus as long-term immunosuppression. The full blood count showed haemoglobin 97 g/L, platelet 2×10 9 /L neutrophil 0.22×10 /L. Peripheral film examination confirmed genuine thrombocytopenia in the absence of any haemolytic or malignant...
Intravenous immunoglobulin (IVIg) is a common therapy for patients with immune thrombocytopenia (ITP). The initial response rate IVIg 80%[1][1] and typically rapid, some responding in 24 hours, although usually 2–4 days.[2][2] When used alone, the
<h3>Background</h3> Ataxia Telangiectasia (AT) is a rare progressive neurodegenerative disorder with no proven interventions to prevent or delay disease progression. Papworth Hospital NHS Foundation Trust nationally commissioned provide an annual multidisciplinary team (MDT) review for adult patients AT following on from their paediatric care. <h3>Methods</h3> We conducted retrospective evaluation of seen between May and November 2013 specifically assessing the outcomes MDT discussion each...