A5054364258- Venous Thromboembolism Diagnosis and Management
- Platelet Disorders and Treatments
- Mechanical Circulatory Support Devices
- Systemic Lupus Erythematosus Research
- Blood Coagulation and Thrombosis Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Atrial Fibrillation Management and Outcomes
- Complement system in diseases
- Heart Failure Treatment and Management
- Central Venous Catheters and Hemodialysis
- Hemoglobinopathies and Related Disorders
- COVID-19 and healthcare impacts
- Diagnosis and Treatment of Venous Diseases
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood groups and transfusion
- Cardiac Arrest and Resuscitation
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood donation and transfusion practices
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
St Thomas' Hospital
2020-2025
Guy's and St Thomas' NHS Foundation Trust
2018-2024
University College London Hospitals NHS Foundation Trust
2022-2023
University College London
2022-2023
National Health Service
2022
University College Hospital
2022
Papworth Hospital
2005
Abstract Post-COVID syndrome (PCS), or long COVID, is an increasingly recognized complication of acute SARS-CoV-2 infection, characterized by persistent fatigue, reduced exercise tolerance, chest pain, shortness breath, and cognitive slowing. Acute COVID-19 strongly linked with increased risk thrombosis, which a prothrombotic state quantified elevated von Willebrand factor (VWF) antigen (Ag)/ADAMTS13 ratio that associated severity infection. We investigated whether patients PCS also had...
Extracorporeal membrane oxygenation is a lifesaving therapy for patients with severe acute respiratory distress syndrome refractory to conventional mechanical ventilation. It frequently complicated by both thrombosis and hemorrhage. A markedly prothrombotic state associated high rates of venous thromboembolism has been described in coronavirus 2 (coronavirus disease 2019) infection. These have currently not during extracorporeal comparison other viral pneumonias.Retrospective observational...
Abstract Introduction Stroke is the most frequent arterial thrombosis in antiphospholipid syndrome (APS) with high rates of recurrence. Methods and patients A retrospective, single‐centre 10‐year review APS having sequential cerebral magnetic resonance imaging (MRI) was performed to describe ischaemic features associated disease risk factors progression over time. Results total 120 307 scans were included 67% receiving vitamin K antagonists (VKA). Note that 65% had baseline white matter...
Myeloproliferative neoplasms (MPN) are associated with an increased rate of venous thromboembolism (VTE), which is a major cause morbidity and mortality, especially in the more indolent diseases polycythaemia rubra vera (PV) essential thrombocythaemia (ET) (Pearson, 2002; Tefferi & Barbui, 2017). Multiple factors underlie complex pathogenesis thrombosis MPN including elevated blood viscosity, thrombocytosis leucocytosis. High levels inflammatory cytokines adhesion molecules, circulating...
The use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) in severe hypoxaemic respiratory failure from coronavirus disease 2019 (COVID-19) has been described, but reported utilisation and outcomes are variable, detailed information on patient characteristics is lacking. We aim to report clinical characteristics, management COVID-19 patients requiring VV-ECMO, admitted over 2 months a high-volume centre the UK.Patient information, including baseline parameters, was collected...
Acute thrombotic thrombocytopenic purpura (TTP) is a life-threatening emergency and plasma exchange (PEX) the initial treatment shown to reduce acute mortality.To compare current practice in United Kingdom (UK) against standards set out 2012 British Society of Haematology guideline, better understand issues affecting prompt initiation PEX.The trainee research network HaemSTAR conducted retrospective nationwide review adults presenting UK hospitals with first episode TTP.Data on 148 patients...
Introduction Vitamin-K antagonists (VKA) are considered the first-line anticoagulants for thrombotic antiphospholipid syndrome (TAPS), particularly with triple positivity or arterial events. However, recurrence remains high despite anticoagulation and other clinical issues may arise. Long-term parenteral therefore be considered, however little is known about viability of fondaparinux in this setting. Materials Methods We describe efficacy safety long-term TAPS (>3-months duration) treated...
Restrictive transfusion policies have been adopted in critical care, although these not included patients receiving extracorporeal membrane oxygenation. We aimed to assess survival outcomes, adverse events related RBC transfusion, and cost implications following a change from "liberal" "restrictive" practice oxygenation.Retrospective observational study.Single high-volume tertiary care department at university hospital.Patients 16 years old or greater venovenous oxygenation between 2011 2017...
There has been a significant surge in admissions to critical care during the coronavirus disease 2019 (COVID-19) pandemic. At present, demands on blood components have not described. We reviewed their use first 6 weeks of outbreak from 3 March 2020 tertiary-level department providing venovenous extracorporeal membrane oxygenation (vv-ECMO). A total 265 patients were reviewed, with 235 requiring ECMO and 30 vv-ECMO. In total, 50 required admission. Red cell concentrates most frequently...
Individuals with inherited antithrombin deficiency (IATD) have a high risk of venous thromboembolism (VTE). Most VTEs are managed direct oral anticoagulants (DOACs), but the utility DOACs in (ATD) is unreported.
Coagulation changes, thrombosis, and hemorrhage have been described in patients following N‐methyl‐3,4‐methylenedioxymethylamphetamine (MDMA) intoxication who subsequently developed serotonin syndrome rhabdomyolysis. The clinical features mechanism of this remain poorly described. We describe 5 sequential cases admitted to critical care due severe recreational MDMA toxicity where coagulopathy occurred, discuss key issues. All presented with hyperpyrexia then subsequent rhabdomyolysis...