A5088751900- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Pregnancy and Medication Impact
- Atherosclerosis and Cardiovascular Diseases
- Lymphoma Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Reproductive System and Pregnancy
- Eosinophilic Esophagitis
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Liver Diseases and Immunity
- Autoimmune and Inflammatory Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pregnancy and preeclampsia studies
- Vasculitis and related conditions
- Biosimilars and Bioanalytical Methods
- Inflammatory Myopathies and Dermatomyositis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory Bowel Disease
- Chronic Lymphocytic Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Birth, Development, and Health
- Bone and Joint Diseases
- Estrogen and related hormone effects
- Myofascial pain diagnosis and treatment
Bassetlaw Hospital
2012-2024
Doncaster Royal Infirmary
2014-2024
Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust
2018-2023
University of Birmingham
2006-2015
Sandwell & West Birmingham Hospitals NHS Trust
2012-2015
University Hospitals Birmingham NHS Foundation Trust
2015
Worcestershire Acute Hospitals NHS Trust
2009-2014
University College London
2012-2014
Leeds Teaching Hospitals NHS Trust
2014
Aberdeen Royal Infirmary
2014
Objective. To devise a more discriminating version of the British Isles Lupus Assessment Group (BILAG) disease activity index and to show that it is reliable.
Objective. The aim of this study was to describe the outcomes and predictors for development damage in a large inception cohort SLE patients. Methods. This prospective longitudinal patients were included if they recruited within 3 years achieving fourth ACR criterion SLE. Data collected on disease activity, treatment. Information death provided by Office National Statistics. censoring date analysis 31 December 2010. A standardized mortality ratio calculated. Poisson regression used determine...
Objectives. Pulmonary arterial hypertension (PAH) is associated with rapid deterioration and poor prognosis in SLE, especially during pregnancy. The prevalence of PAH SLE non-tertiary centres uncertain. This study aims to estimate the point identify risk factors for a large cohort patients. Methods. A prospective cross-sectional 288 patients were recruited from lupus clinics Birmingham, UK. Resting transthoracic echocardiography was performed pulmonary artery pressures assess cardiac...
Abstract Objective To determine the construct and criterion validity of British Isles Lupus Assessment Group 2004 (BILAG‐2004) index for assessing disease activity in systemic lupus erythematosus (SLE). Methods Patients with SLE were recruited into a multicenter cross‐sectional study. Data on (scores BILAG‐2004 index, Classic BILAG Systemic Erythematosus Disease Activity Index 2000 [SLEDAI‐2K]), investigations, therapy collected. Overall overall scores determined by highest score achieved...
To describe the baseline characteristics of SLE patients requiring biologic therapy in UK and to explore short term efficacy infection rates associated with rituximab (RTX) use. Patients commencing for refractory who consented join BILAG-BR were analysed. Baseline characteristics, disease activity (BILAG 2004/SLEDAI-2K) over follow-up Response was defined as loss all A B BILAG scores ⩽ 1 score no new A/B other organ systems at 6 months. Two hundred seventy commenced from September 2010 2015,...
Abstract Objective To test the interrater reliability of revised British Isles Lupus Assessment Group 2004 (BILAG‐2004) index for assessment systemic lupus erythematosus (SLE) activity. Methods Patients with SLE were recruited from 11 centers. Two physician raters separately assessed patients' disease activity using BILAG‐2004 in routine clinical practice. Scores ranged A (for very active disease) to E inactivity). exercises performed. Changes made after first exercise (E1), and additional...
As a health-related quality of life (HRQOL) measure, the LupusQoL is reliable and valid measure for adults with systemic lupus erythematosus (SLE). This study evaluates responsiveness minimal important differences (MIDs) 8 domains.Patients experiencing flare were recruited from 9 UK centers. At each 10 monthly visits, HRQOL (LupusQoL, Short Form 36 health survey [SF-36]), global rating change (GRC), disease activity using British Isles Lupus Assessment Group 2004 index assessed. The SF-36...
Abstract Objectives To determine whether SLE patients with inflammatory joint symptoms and US synovitis/tenosyovitis achieve better clinical responses to glucocorticoids compared normal scans. Secondary objectives included identification of features predicting synovitis/tenosynovitis. Methods In a longitudinal multicentre study, physician-diagnosed pain received intramuscular methylprednisolone 120 mg once. Clinical assessments, patient-reported outcomes bilateral hand/wrist USs were...
Abstract Objectives To improve the definitions of inflammatory arthritis within musculoskeletal (MSK) domain BILAG-2004 index by incorporating imaging findings and clinical features predictive response to treatment. Methods The BILAG MSK Subcommittee proposed revisions arthritis, based on review evidence in two recent studies. Data from these studies were pooled analysed determine impact changes severity grading arthritis. Results revised definition for severe includes ‘basic activities...
Objective. To develop an additive numerical scoring scheme for the Classic BILAG index. Methods. SLE patients were recruited into this multi-centre cross-sectional study. At every assessment, data collected on disease activity and therapy. Logistic regression was used to model increase in therapy, as indicator of active disease, by score eight systems. As both indicate inactivity, scores D E set 0 baseline fitted model. The coefficients from determine values Grades A, B C. Different schemes...
Objective. To assess the inter-rater reliability of BILAG2004-Pregnancy index for assessment SLE disease activity in pregnancy.
BILAG-2004 index is a comprehensive disease activity instrument for SLE but administrative burden and potential frequency of errors limits its use in routine practice. We aimed to develop tool more accurate, time-efficient scoring with full fidelity the existing instrument.
SLE is characterized by relapses and remissions. We aimed to describe the frequency, type time flare in a cohort of patients.SLE patients with one or more 'A' 'B' BILAG-2004 systems meeting criteria ('new' 'worse' items) requiring an increase immunosuppression were recruited from nine UK centres assessed at baseline monthly for 9 months. Subsequent flares defined as: severe (any irrespective number flares), moderate (two without any flares) mild (one 'B').Of 100 patients, 94% female, 61%...
Abstract Objectives GCA can be confirmed by temporal artery biopsy (TAB) but false negatives occur. may overdiagnosed in TAB-negative cases, or if neither TAB nor imaging is done. We used HLA genetic association of TAB-positive as an ‘unbiased umpire’ test to estimate historic overdiagnosis GCA. Methods Patients diagnosed with between 1990 and 2014 were genotyped. During this era, vascular alone was rarely diagnose region variants jointly imputed from genome-wide genotypic data cases...
For further information and caveats, see relevant recommendations main text in the Executive Summary full Guideline.a Intermittent use advised-see for details.b Based on limited data no association with adverse foetal development or pregnancy outcome, therefore unlikely to be harmful.c Limited evidence, but harmful.d evidence regarding treatment of chronic pain pregnancy.High dose folic acid (5 mg/day) recommended.e Cessation anti-depressant therapy post-natal period is not recommended.f...