A5001822897- Advanced X-ray Imaging Techniques
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Digital Radiography and Breast Imaging
- Laser-Plasma Interactions and Diagnostics
- Crystallography and Radiation Phenomena
- Advanced MRI Techniques and Applications
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- X-ray Diffraction in Crystallography
- Digital Holography and Microscopy
- Glass properties and applications
- Radiation Therapy and Dosimetry
- Enzyme Structure and Function
- Laser Design and Applications
- Advanced Electron Microscopy Techniques and Applications
- Laser-induced spectroscopy and plasma
- nanoparticles nucleation surface interactions
- Nuclear materials and radiation effects
- Neurotransmitter Receptor Influence on Behavior
- Radiation Shielding Materials Analysis
- Photodynamic Therapy Research Studies
- Viral Infections and Vectors
- Advancements in Photolithography Techniques
University at Albany, State University of New York
2015-2025
Albany State University
1992-2025
Mott MacDonald (United Kingdom)
2018
Cardiovascular Research Center
2018
African Organisation for Research and Training in Cancer
2018
Harvard University
1985-2018
Massachusetts General Hospital
2018
Bates College
2018
Albany Medical Center Hospital
2012
Intel (United States)
2012
Abstract Thoracic aortic aneurysm (TAA) has been associated with mutations affecting members of the TGF-β signaling pathway, or components and regulators vascular smooth muscle cell (VSMC) actomyosin cytoskeleton. Although both clinical groups present similar phenotypes, existence potential common mechanisms pathogenesis remain obscure. Here we show that VSMC cytoskeleton lead to formation a ternary complex comprising histone deacetylase HDAC9, chromatin-remodeling enzyme BRG1, long...
Background: Previous studies describing genetics evaluation in spontaneous coronary artery dissection (SCAD) have been retrospective nature or presented as single case reports. As part of a dedicated clinical program, we evaluated patients cardiovascular clinic to determine the role genetically triggered vascular disease and genetic testing SCAD. Methods Results: Patient data were entered prospectively into Massachusetts General Hospital SCAD registry database from July 2013 September 2017....
Background: The role of exclusion diets in the management atopic eczema young children is uncertain. This randomised controlled trial evaluates effect excluding egg from diet with and sensitivity to eggs. Fifty‐five such were either a 4‐week regimen, which mothers given general advice on care additional specific dietician about an (diet group), or control group only was given. Both groups continued conventional topical treatment. Disease activity assessed by estimates surface area affected...
A summary of focusing X ray polycapillary optics is presented including history, theory, modeling, and applications development. The effects come from the overlap beams thousands small hollow glass tubes. Modeling efforts accurately describe performance to allow for system development in a wide variety geometries. with yields high gains intensity increased spatial resolution clinical, lab-based, synchrotron or situ analysis applications.
Conventional x-ray radiography relies on attenuation differences in the object, which often results poor contrast soft tissues. X-ray phase imaging has potential to produce higher but can be difficult utilize. Instead of grating-based techniques, analyzer-based imaging, also known as diffraction enhanced (DEI), uses a monochromator crystal with an analyzer after object. Analyzer-based systems most commonly employ synchrotron sources provide adequate intensity, and typically use photon...
Abstract The Plasma Injector 3 (PI3) experiment at general fusion has been constructed to demonstrate the ability form plasma targets suitable for compression in a Magnetized Target Fusion machine. To achieve compressive heating conditions, target plasmas should have an energy confinement time sufficiently excess of time. In this work we present methodology calculating timescale and results large set discharges. Characterization current profiles reveals trends groupings determined by machine...
Crystallization rates in pure metals have been measured by monitoring changes reflectivity on a picosecond time scale during pulsed laser quenching. Multilayered films were used to establish that the transient decreases correspond melting. Depth profiling with Auger electron spectroscopy laser-irradiated areas showed complete mixing of layers, which could only occurred velocities as high 100 m/s measured. These growth speeds are too large be result crystallization process governed liquid...
Loss-of-function mutations in genes encoding contractile proteins have been observed thoracic aortic aneurysms (TAA). To gain insight into the contribution of protein deficiency pathogenesis TAA, we examined human aneurysm samples. We found multiple gene products deficient TAA samples, and particular, expression SM22α was inversely correlated with size. SM22α-deficient mice demonstrated pregnancy-induced dissection, worsened Fbn1C1039G/+ (Marfan) mice, validating this product as a effector....
Abstract Polycapillary optics can be designed for a wide variety of x‐ray applications. They have been used as focusing collectors astronomy, to produce large‐area collimated beams wafer analysis and provide small focused protein crystallography with low‐power sources. are also being developed number medical applications, including the removal Compton scattering resultant improvement in contrast resolution mammography, production monochromatic parallel high‐contrast imaging clinical setting...
A transmission x-ray imaging setup based on a confocal combination of polycapillary focusing optic followed by collimating was designed and demonstrated to have good resolution, better than the unmagnified pixel size unlimited tube spot size. This has potential application in for small samples, example, histology specimens.
In order to investigate the feasibility of using Kumakhov capillary x-ray optics for high energy applications, measurements have been performed on behavior from 10 80 keV. Transmission efficiencies straight polycapillary fibers different types measured as a function source location and energy. The are analyzed geometrical simulation program, which includes roughness waviness effects. Despite low critical angle total external reflection at energies, appear promising many hard applications....
The electrical and dielectric properties of Ba0.8Sr0.2TiO3 thin films Ba0.8Sr0.2TiO3/ZrO2 multilayer deposited on Pt/Ti/SiO2/Si substrates by sol-gel method are studied. temperature dependence the for pure film has been studied in range from 90 to 500 K. Both constant loss exhibit minimal dispersion as a function this range. It is observed that constant, loss, tunability reduced films. Additionally, ferroelectricity disappears Our results show multilayered design excellent they stable over...
Computed radiography (CR) has shown promise in digital mammographic screening due to its good low spatial frequency MTF and relatively wide exposure latitude. The CR image format not gained acceptance clinically because of reduced high resolution as compared film-screen images. X-ray capillary optics, aligned between the breast phosphor imaging plate, will capture primary x-ray photons almost exclusively. Due very small angle acceptance, scattered angled more than about 1.6 x 10(-3) radians...
Polycapillary optics, i.e. shaped arrays consisting of hundreds thousands hollow glass capillary tubes, can be used to redirect, collimate or focus X-ray beams. X-rays emitted over a large angular range from conventional laboratory-based sources transformed into beam with small divergence focused onto sample area. Convergent beams X-rays, convergence angles as high 15°, have been produced using polycapillary optics. Focused-spot sizes 20 µm achieved, flux densities two orders magnitude...
Assemblies of hollow capillary tubes, termed ‘‘Kumakhov optics,’’ can be used to control x rays for a large variety applications. Measurements x-ray transmission in polycapillary glass tubes were performed the purpose understanding their behavior such devices. X-ray was measured straight, uniformly curved, and nonuniformly bent fibers. The data agree well with computer simulation based on classical ray tracing.
Monochromatic imaging can provide better contrast and resolution than conventional broadband radiography. In systems, low energy photons do not contribute to the image, but are merely absorbed, while high produce scattering that degrades image. By tuning optimal energy, one eliminate undesirable lower higher energies. Monochromatization is achieved by diffraction from a single crystal. A crystal oriented diffract at particular in this case characteristic line diffracts only those within...
Metamaterials provide a challenge for materials analysis, as large-scale 3D geometries confound traditional methods. X-ray optics that allow novel beam and more efficient use of conventional sources can be important in defect structure analysis to close the loop between design performance. Fortunately, metamaterials have also provided new variety array structured optics. Because X-rays barely interact with materials, their index refraction any material is only slightly different from unity,...
X-ray phase-contrast imaging produces significantly higher contrast than the conventional attenuation-based imaging. However, phase typically requires small low-power sources or precisely machined and aligned gratings to generate required spatial coherence. To overcome this limitation, we use a simple wire mesh produce periodic intensity pattern in illumination. Distortions upon propagation through an object can be used images. Unlike Talbot-grating-based techniques, directly provides...
Megavoltage photon beams are typically used for therapy because of their skin-sparing effect. However, a focused low-energy x-ray beam would also be skin sparing, and have higher dose concentration at the focal spot. Such can produced with polycapillary optics. MCNP5 was to model profiles scanned beam, using measured parameters. The potential low energy radiation assessed.A optic focus from tungsten source. characterized measurements were performed 50 kV. PMMA blocks varying thicknesses...