A5056965202- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Ultrasound and Cavitation Phenomena
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Infrared Thermography in Medicine
- Intracerebral and Subarachnoid Hemorrhage Research
- Dementia and Cognitive Impairment Research
- Welding Techniques and Residual Stresses
- Neurological disorders and treatments
- Non-Destructive Testing Techniques
- Additive Manufacturing Materials and Processes
- Hypothalamic control of reproductive hormones
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Advanced MRI Techniques and Applications
- Thermography and Photoacoustic Techniques
- Vagus Nerve Stimulation Research
- Wireless Body Area Networks
- Neurobiology and Insect Physiology Research
- Ultrasonics and Acoustic Wave Propagation
- Neonatal and fetal brain pathology
Sunnybrook Health Science Centre
2016-2024
Sunnybrook Research Institute
2016-2024
Sunnybrook Hospital
2017-2022
University of Toronto
2016-2021
University of Guelph
2014
Rationale: Focused ultrasound (FUS), in conjunction with circulating microbubbles (MBs), can be used to transiently increase the permeability of blood-brain barrier (BBB) a targeted manner, allowing therapeutic agents enter brain from systemic circulation.While promising preclinical work has paved way for initiation 3 human trials, there remains concern regarding neuroinflammation following treatment.The aim this study was assess magnitude response sonication and explore influence MB...
Abstract Therapeutic treatment options for central nervous system diseases are greatly limited by the blood-brain barrier (BBB). Focused ultrasound (FUS), in conjunction with circulating microbubbles, can be used to induce a targeted and transient increase BBB permeability, providing unique approach delivery of drugs from systemic circulation into brain. While preclinical research has demonstrated utility FUS, there remains large gap our knowledge regarding impact sonication on gene...
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening recently entered clinical testing for targeted drug delivery to the brain. Sources of variability exist in current procedures, motivating development real-time monitoring and control techniques improve treatment safety efficacy. Here we used three-dimensional (3D) transcranial microbubble imaging calibrate FUS exposure levels volumetric BBB opening. Methods: Using a sparse hemispherical transmit/receive phased array, pulsed...
Rationale: Clinical trials are currently underway to test the safety and efficacy of delivering therapeutic agents across blood-brain barrier (BBB) using focused ultrasound microbubbles (FUS+MBs).While acoustic feedback control strategies have largely minimized risk overt tissue damage, transient induction inflammatory processes been observed following sonication in preclinical studies.The goal this work was explore potential post-sonication dexamethasone (DEX) administration as a means...
Transcranial magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) thermal ablation is under clinical investigation for non-invasive neurosurgery, though its use restricted to central brain targets due primarily skull heating effects.The combination of FUS and contrast agent microbubbles greatly reduces the exposure levels needed ablate tissue may help facilitate transcranial throughout brain.However, sources variability exist during microbubble-mediated procedures that...
Abstract Focused ultrasound and microbubble (FUS + MB)-mediated blood–brain barrier (BBB) permeability enhancement can facilitate targeted brain-drug delivery. While controlling the magnitude of BBB is necessary to limit tissue damage, little work has attempted decouple these concepts. This investigated relationship between relative transcription inflammatory mediators 4 h following sonication. Three formulations, Definity, BG8774, MSB4, were compared, with dose each formulation normalized...
Focused ultrasound (FUS) and circulating microbubbles can induce a targeted transient increase in blood-brain barrier permeability. While preclinical research has demonstrated the utility of FUS for efficacious drug deliver to brain, there remain gaps our knowledge regarding long-term response brain vasculature this intervention. Previous work transcriptional changes hippocampal microvessels following sonication that are indicative initiation angiogenic processes. Moreover, blood vessel...
Abstract Strong evidence demonstrates a significant association between cerebral amyloid angiopathy (CAA) and Alzheimer’s disease (AD). For this reason, interest in understanding the underlying vascular pathologies that contribute to AD remain. CAA research has primarily focused on arterioles capillaries, overlooking draining venules. Therefore, study sought examine venular pathology its relationship arteriolar amyloidosis throughout progression TgF344-AD rat model. Antibodies targeting...
Basal forebrain cholinergic neurons (BFCNs) regulate circuit dynamics underlying cognitive processing, including attention, memory, and flexibility. In Alzheimer's disease related neurodegenerative conditions, the degeneration of BFCNs has long been considered a key player in decline. The system thus represents therapeutic target. A long-standing obstacle for development effective cholinergic-based therapies is not only production biologically active compounds but also platform safe...
MRI is commonly employed to assess microbubble-mediated focused ultrasound (FUS) treatment outcomes, but restricted post-treatment evaluations due its low temporal resolution. Here, we describe a modular sparse hemispherical transmit/receive phased array for FUS brain therapy and simultaneous 3D passive cavitation imaging (PCI) real-time intraoperative monitoring control. The device was evaluated via MR-guided experiments in rabbits. utility of PCI calibrating exposure levels predicting...
Focused ultrasound (FUS) combined with circulating microbubbles (MBs) can be employed for non-invasive, localized agent delivery across the blood-brain barrier (BBB). Previous work has demonstrated feasibility of clinical-scale transmit-receive phased arrays performing transcranial therapies under MB imaging feedback.
Focused ultrasound (FUS) and microbubble (MB) exposure is a promising technique for targeted drug delivery to the brain; however, refinement of protocols suitable large-volume treatments in clinical setting remains underexplored.
Abstract Background In Alzheimer’s Disease (AD), the amyloid‐beta peptide (Aβ) aggregates and deposits in form of amyloid plaques within brain parenchyma. Overproduction Aβ is less common sporadic AD cases, suggesting that impairment clearance contributes to disease pathology. AD, failure perivascular drainage pathway leads deposition walls cerebral blood vessels, resulting angiopathy (CAA). The association between with arterioles capillaries known, however, present venules still...
Removed.
Abstract Strong evidence demonstrates a significant association between cerebral amyloid angiopathy and Alzheimer’s disease (AD). For this reason, interest in understanding the underlying vascular pathologies that contribute to AD remain. Cerebral research has primarily focused on arterioles capillaries, overlooking draining venules. Therefore, study sought examine venular pathology its relationship arteriolar amyloidosis throughout progression TgF344-AD rat model. Antibodies targeting...
Over the past 15 years, use of passive sensor arrays combined with established beamforming algorithms to image acoustic activity during ultrasound therapies, so-called mapping (PAM), has been increasingly investigated for cavitation-based treatment monitoring and control purposes. Our group is interested in applications microbubble-mediated therapy brain, which skull bone presents unique challenges both delivery emissions monitoring. We have demonstrated that skull-specific transcranial...