A5041421122- Ultrasound and Hyperthermia Applications
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- Virus-based gene therapy research
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Photoacoustic and Ultrasonic Imaging
- Viral gastroenteritis research and epidemiology
- Mesenchymal stem cell research
- Spinal Cord Injury Research
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Vagus Nerve Stimulation Research
- RNA regulation and disease
- Extracellular vesicles in disease
- Spinal Dysraphism and Malformations
- Ultrasound Imaging and Elastography
- Drug Transport and Resistance Mechanisms
- Neurological disorders and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Barrier Structure and Function Studies
- Dementia and Cognitive Impairment Research
- Neurological Disease Mechanisms and Treatments
Sunnybrook Health Science Centre
2013-2024
Ontario Brain Institute
2024
Sunnybrook Research Institute
2013-2022
University of Toronto
2016-2022
Sunnybrook Hospital
2016-2021
University Health Network
2019-2020
Krembil Research Institute
2019-2020
Wake Forest University
2019
Forest Institute
2019
John Wiley & Sons (United States)
2019
ABSTRACT Background: The characteristic progression of Lewy pathology in Parkinson's disease likely involves intercellular exchange and the accumulation misfolded α‐synuclein amplified by a prion‐like self‐templating mechanism. Silencing gene could provide long‐lasting disease‐modifying benefits reducing requisite substrate for spreading aggregation. Objectives: As result poor penetration viral vectors across blood–brain barrier, therapy central nervous system disorders requires direct...
Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in mouse model Alzheimer’s disease.
Focused ultrasound combined with intravenously injected microbubbles (FUS) is known to non-invasively, locally, and transiently increase the permeability of blood-brain barrier (BBB). A promising approach for non-invasive gene delivery brain administer recombinant adeno-associated viruses (AAVs) allow them cross BBB at precise FUS-targeted regions. FUS-AAV has been achieved in animal models; however, key elements influencing, guiding, monitoring success remain largely unknown. We...
Abstract Early degeneration of basal forebrain cholinergic neurons contributes substantially to cognitive decline in Alzheimer’s disease. Evidence from preclinical models neuronal injury and aging support a pivotal role for nerve growth factor (NGF) neuroprotection, resilience, function. However, whether NGF can provide therapeutic benefit the presence disease-related pathologies still unresolved. Perturbations signalling system disease may render unable administration. Additionally,...
Evidence suggests that physical exercise can serve as a preventive strategy against Alzheimer's disease (AD). In contrast, much less is known about the impact of when it introduced after cognitive deficits are established. Using TgCRND8 mouse model amyloidosis, we compared ef fects an intervention aimed at altering progression. Voluntary running for 1 month or 2 months was in 3-month-old mice, which exhibit amyloid-beta (Aβ) plaque pathology and this age. Specifically, examined Aβ load,...
Abstract Localized vascular disruption after traumatic spinal cord injury (SCI) triggers a cascade of secondary events, including inflammation, gliosis, and scarring, that can further impact recovery. In addition to immunomodulatory neurotrophic properties, mesenchymal stromal cells (MSCs) possess pericytic characteristics. These features make MSCs an ideal candidate for acute cell therapy targeting disruption, which could reduce the severity injury, enhance tissue preservation repair,...
Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co-exist. The impact of concurrent on the pattern hippocampal atrophy, a key substrate memory impacted early extensively in dementia, remains poorly understood.
Cell therapy offers significant promise for traumatic spinal cord injury (SCI), which despite many medical advances, has limited treatment strategies. Able to address the multifactorial and dynamic pathophysiology of SCI, cells present various advantages over standard pharmacological approaches. However, use live is also severely hampered by logistical practical considerations. These include specialized equipment expertise, standardization cell stocks, sustained viability post-thawing,...
Basal forebrain cholinergic neurons (BFCNs) regulate circuit dynamics underlying cognitive processing, including attention, memory, and flexibility. In Alzheimer's disease related neurodegenerative conditions, the degeneration of BFCNs has long been considered a key player in decline. The system thus represents therapeutic target. A long-standing obstacle for development effective cholinergic-based therapies is not only production biologically active compounds but also platform safe...
Abstract The accumulation of aggregated alpha-synuclein (α-syn) in Parkinson's disease, dementia with Lewy bodies and multiple system atrophy is thought to involve a common prion-like mechanism, whereby misfolded α-syn provides conformational template for further pathological α-syn. We tested whether silencing gene expression could reduce native non-aggregated substrate thereby disrupt the propagation initiated by seeding synucleinopathy-affected mouse brain homogenates. Unilateral...
Cerebrovascular integrity is fundamental for neuronal function. A robust and healthy vascular network required normal development, maintenance transmission. In the pathological context, cerebral vasculature gaining recognition as an important therapeutic target Alzheimer's disease (AD). Changes to morphology are associated with accumulation of amyloid beta (Aβ) plaques, angiopathy (CAA), which compromises cerebrovasculature induces neurotoxicity, resulting in cognitive impairment. Physical...