We treated 17 patients who had moderate to severe Alzheimer's disease with oral tetrahydroaminoacridine (THA), a centrally active anticholinesterase, in three-phase study. In the nonblinded first phase of study, significant improvement occurred subjects received drug, as compared their pretreatment status, on global assessment (P = 0.001), Orientation Test and more sophisticated Names Learning 0.001). During second phase, served own controls double-blind, placebo-controlled, cross-over study...

Background. An increased incidence of de novo nonlymphoid malignancies has been shown in immunocompromised patients. However, the true risk over time compared to general population not determined. Methods. One thousand consecutive patients were carefully followed for an average 77.8±11.1 (range, 56.3-96.3) months after primary liver transplantation at a single center. All recorded. Each malignancy was with standard Occupational Cohort Mortality Analysis Program matched age, sex, and length...

This is an update of earlier study on the relation between exposure to arsenic in air and deaths from respiratory cancer. The purpose was verify findings a supralinear dose response examine relations with other cancers, particularly those reported studies drinking water.An 2802 men who worked at copper smelter for year or more during period 1940-64 were followed up 1941-76 updated until 1986. Estimates 1977-1984 added.The additional follow confirms finding that low doses increments death...

A cohort of 8854 men, 2293 whom were exposed to acrylamide, was examined from 1925 1983 for mortality. This consisted four plant populations in two countries: the United States and The Netherlands. No statistically significant excess all-cause or cause-specific mortality found among acrylamide workers. Analysis by exposure levels showed no trend increased risk several cancer sites. These results do not support hypothesis that is a human carcinogen.

Journal Article EXPOSURE TO ARSENIC AND RESPIRATORY CANCER A REANALYSIS Get access PHILIP E. ENTERLINE, ENTERLINE 1Department of Biostatistics, Graduate School Public Health, University PittsburghPittsburgh, PA 152612Center for Environmental Epidemiology, Reprint requests to Dr. Philip R Enterline Search other works by this author on: Oxford Academic PubMed Google Scholar VIVIAN L. HENDERSON, HENDERSON 2Center GARY M. MARSH American Volume 125, Issue 6, June 1987, Pages 929–938,...

Journal Article CANCER AMONG WORKERS EXPOSED TO ARSENIC AND OTHER SUBSTANCES IN A COPPER SMELTER Get access PHILIP E. ENTERLINE, ENTERLINE Reprint requests to Dr Enterline Search for other works by this author on: Oxford Academic PubMed Google Scholar GARY M. MARSH American of Epidemiology, Volume 116, Issue 6, December 1982, Pages 895–911, https://doi.org/10.1093/oxfordjournals.aje.a113492 Published: 01 1982 history Received: 12 July

Fibrous glass and mineral wool workers exposed to airborne man-made fibers prior 1964 were identified followed for deaths caused by respiratory disease. Fiber exposure levels estimated each worker. Average fiber concentrations very low in relation a National Institute of Occupational Safety Health recommendation that less than 3.5 microns diameter be limited 3 per cubic centimeter air. about one hundredth tenth amount. Respiratory cancer death rates not excessive the fibrous workers, but...

OBJECTIVE: To update the mortality experience of a cohort 8508 workers with potential exposure to acrylamide at three plants in United States from 1984-94. METHODS: Analyses standardised ratios (SMR) national and local rates relative risk (RR) regression modelling were performed assess site specific cancer risks by demographic work history factors, indicators for muriatic acid. RESULTS: For 1925-94 study period, excess deficit overall found sites interest: brain other central nervous system...

This 1983 to 1985 update of an earlier study examined the mortality experience 16 661 man-made mineral fiber workers employed 1 year or more (6 months for two plants) during 1945 1963 (1940 one plant) at 17 US manufacturing plants. Using local death rates estimate expected deaths there was a small statistically significant (P < .05) excess in all malignant neoplasms (standardized ratio [SMR] = 108.3) and respiratory cancer (SMR 112.1) total period 1946 1985. For greatest wool workers. glass...

This 1978–1982 update of an earlier study examined the 1946–1982 mortality experience 16 661 man-made mineral fibre workers employed 1 yr or more (6 months for two plants) during 1945–1963 (1940–1963 one plant) at 17 U.S. manufacturing plants. Using local death rates to estimate expected deaths there was a statistically significant excess in all malignant neoplasms and lung cancer 20 after first employment. For respiratory greatest wool ever exposed production small diameter fibres. These...

We conducted a systematic review of the epidemiologic literature for glyphosate focusing on non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM) - two cancers that were focus recent by an International Agency Research Cancer Working Group. Our approach was consistent with Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines reviews. evaluated each relevant study according to priori criteria quality: adequacy size, likelihood confounding, potential other biases...

ABSTRACT Objective To evaluate if workers exposed to styrene in reinforced plastics and composite facilities between 1948 1977 experienced elevated cancer mortality or risk. Methods We performed a update of 15,826-worker cohort followed from through 2019. computed standardized ratios (SMR) comparing observed deaths expected based on US national- state-level age-, race-, sex-, time-specific rates, evaluated exposure-response trends. Results Respiratory system (SMR = 1.30; 95% CI 1.22-1.39)...

Objective: The objective of this study was to update the mortality experience a cohort workers with and without potential exposure acrylamide (AMD) at three U.S. plants (n = 8508) one plant in Netherlands 344). Methods: We computed standardized ratios (SMRs) using national local rates modeled internal assess site-specific cancer risks by demographic work history factors several indicators for AMD. Results: For 1925–2002 period, we observed both deficit excess overall among sites implicated...