A5013508041- Sperm and Testicular Function
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Antioxidant Activity and Oxidative Stress
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Reproductive Physiology in Livestock
- Genetic and phenotypic traits in livestock
- Animal Nutrition and Physiology
- Selenium in Biological Systems
- Adipose Tissue and Metabolism
- Endometriosis Research and Treatment
- Meat and Animal Product Quality
- Circular RNAs in diseases
- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Pregnancy and preeclampsia studies
- Animal Genetics and Reproduction
- Animal Disease Management and Epidemiology
- Moringa oleifera research and applications
- Aquaculture Nutrition and Growth
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- Congenital limb and hand anomalies
Beijing University of Agriculture
2016-2025
Guangdong Ocean University
2020
Peking University
2014-2015
Chinese Academy of Agricultural Sciences
2007-2013
Institute of Animal Sciences
2010-2013
New York State College of Veterinary Medicine
2010
Cornell University
2010
As a pivotal player in spermatogenesis, the blood-testis barrier (BTB) made from junction apparatus coexisting Sertoli cells (SCs) is impaired with an increase age and ultimately induces spermatogenic dysfunction or even infertility. It has been corroborated that bone marrow mesenchymal stem cell (BMSC) transplantation can efficiently repair regenerate testicular function. vital mediators of cell-to-cell communication, MSC-derived exosomes (Exos) directly serve as therapeutic agents for...
Abstract Fatness traits are important in pigs because of their implications for fattening efficiency, meat quality, reproductive performance and immunity. Songliao black Landrace show differences production quality traits, including fatness muscle growth. Therefore, we used a high-throughput massively parallel RNA-seq approach to identify genes differentially expressed backfat tissue between these two breeds (six each). An average 37.87 million reads were obtained from the 12 samples. After...
The present study evaluated the effects of natural astaxanthin (ASTA) from Haematococcus pluvialis on antioxidant capacity, lipid metabolism, and ASTA accumulation in egg yolk laying hens. Hy-Line Brown layers (n = 288, 50 wk old) were randomly assigned to 1 4 dietary treatment groups. Each group had 6 replicates 12 hens each. All birds given a corn-soybean meal–based diet containing 0, 25, 50, or 100 mg/kg for wk. results showed that total superoxide dismutase level, glutathione peroxidase...
Chicken meat quality and flavor are determined by abundant metabolites. In this study, HPLC-QTRAP-MS-based metabolomic analysis was used to evaluate the characteristic metabolites in breast muscle of Beijing You chickens aged 56, 98, 120 days. A total 544 32 categories were identified, among which amino acids organic most abundant. 60 55 differential identified between 56 98 days age, respectively. The content l-carnitine, l-methionine 3-hydroxybutyrate increased significantly at or age....
The flavor of chicken meat is influenced by muscle metabolites and regulatory genes varies with age. In this study, the metabolomic transcriptomic data breast at four developmental stages (days 1, 56, 98, 120) Beijing-You chickens (BJYs) were integrated 310 significantly changed (SCMs) 7,225 differentially expressed (DEGs) identified. A Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis showed that SCMs DEGs enriched in amino acid, lipid, inosine monophosphate (IMP) metabolism...
Canine hip dysplasia (HD) is a common polygenic trait characterized by malformation that results in osteoarthritis (OA). The condition dogs very similar to developmental of the human which also leads OA.
Sperm motility is an important index for the evaluation of semen quality. Improving sperm to improve reproductive performance, promote breeding process, and reduce production cost. However, molecular mechanisms regulating in chickens remain unclear. In this study, histological observation whole-transcriptome analysis were performed on testicular tissue with high low motility. Histological observations showed that roosters exhibited better quality than those addition, germinal epithelial...
Intramuscular fat (IMF) is an important indicator for evaluating meat quality. Transcriptome sequencing (RNA-seq) widely used the study of IMF deposition. Machine learning (ML) a new big data fitting method that can effectively fit complex data, accurately identify samples and genes, it plays role in omics research. Therefore, this aimed to analyze RNA-seq by ML differentially expressed genes (DEGs) affecting deposition pigs. In study, total 74 from muscle tissue were used. A 155 DEGs...
The genetic foundations underlying the observed disease resistance in certain indigenous pig breeds, notably Min pigs of China, present a compelling underexplored subject study. Exploring mechanisms these breeds could lay groundwork for improvements immunity, potentially augmenting overall productivity. In this study, whole blood samples were collected from pre- and post- swine fever vaccinated Large White transcriptome sequencing. mRNA lncRNA both analyzed, intra-group inter-group...
Intramuscular fat (IMF) content is closely linked to meat quality, and the process of IMF deposition intricate. Despite numerous transcriptomic studies on IMF, varying sample sizes data analysis methods have led inconsistent gene expression patterns results. To identify pivotal genes influencing pig content, we performed a meta-analysis 10 muscle transcriptome datasets with total eighty samples, including forty each high samples. We used DESeq2 analyze low groups for datasets, identifying...
To determine whether a mutation in the fibrillin 2 gene (FBN2) is associated with canine hip dysplasia (CHD) and osteoarthritis dogs.1,551 dogs. Procedures-Hip conformation was measured radiographically. The FBN2 sequenced from genomic DNA of 21 Labrador Retrievers Greyhounds, haplotype intron 30 90 additional 143 dogs 6 other breeds. Steady-state values mRNA control genes were joint tissues fourteen 8-month-old Retriever-Greyhound crossbreeds.The homozygous for 10-bp deletion had...
The discovery and identification of Ovis aries (sheep) miRNAs will further promote the study miRNA functions gene regulatory mechanisms. To explore microRNAome (miRNAome) sheep in depth, samples were collected that included eight developmental stages: longissimus dorsi muscles Texel fetuses at 70, 85, 100, 120, 135 days, Ujumqin d, lambs 0 (birth), 35, 70 d. These covered all representative periods growth development throughout gestation (about 150 d) d after birth. libraries separately...
Doublesex and mab-3-related transcription factor (dmrt) genes are widely distributed across various biological groups play critical roles in sex determination neural development. Here, we applied bioinformatics methods to exam cross-species changes the dmrt family members evolutionary relationships of based on genomes 17 fish species. All examined species have dmrt1–5 while only five contained dmrt6. Most fishes harbored two dmrt2 subtypes (dmrt2a dmrt2b), with dmrt2b being unique fishes. In...
The objective of this study was to evaluate the effects natural astaxanthin (ASTA) from Haematococcus pluvialis on production performance, egg quality, antioxidant enzyme activity, free radical scavenging ability, and gene expression enzymes in laying hens. Nongda No. 3 hens (n = 450) were randomly allocated 1 5 dietary treatments. Each treatment had 6 replicates 15 each. All birds assigned a corn-soybean meal-based diet containing 0, 20, 40, 80, or 160 mg/kg ASTA for 4 wk. With increasing...
Natural astaxanthin (ASTA) has strong antioxidant properties and been widely used as a health product to improve human health. However, the effects of ASTA on reproductive performance aging roosters have poorly studied. We aimed investigate dietary semen quality capacity in explore potential mechanism change via anti-oxidation defense system.In present study, 96 53-week-old Jinghong No. 1 layer breeder were fed corn-soybean meal basal diet containing 0, 25, 50, or 100 mg/kg for 6 weeks.Semen...
Aims: The study aimed to evaluate the effects of pretreated Chinese herbal medicine (PCHM) on egg quality, production performance, histopathological changes in uterus, antiox idant capacity, and antioxidant gene expression late-phase layers. Methods: Jinghong No.1 layers (n = 360, 68 weeks old) were assigned randomly one f our dietary interventions. Each treatment was replicated six times. Repeat 15 chickens per g roup. All birds fed a diet composed corn-soybean meal-based supplemented with...
Intramuscular fat (IMF) is an essential trait closely related to meat quality. The IMF a complex quantitative that regulated by multiple genes. In order better understand the process of and explore key factors affecting deposition, we identified differentially expressed mRNA, miRNA, lncRNA in longissimus dorsi muscle (LD) between Songliao Black (SL) pigs Landrace pigs. We obtained 606 genes (DEGs), 55 miRNAs (DEMs), 30 lncRNAs (DELs) SL pig pig. Enrichment results from GO KEGG indicate DEGs...
Chickens play a crucial role as the primary global source of eggs and poultry, quality rooster semen significantly impacts poultry reproductive efficiency. Therefore, it is imperative to comprehend regulatory mechanisms underlying sperm development. In this study, we established transcriptome profiles lncRNAs, miRNAs, mRNAs in 3 testis tissues epididymis from "Jing Hong No.1" roosters at 24, 35, 64 weeks age. Using data, conducted whole analysis constructed ceRNA network. We detected 10...