A5071341910- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Immune cells in cancer
- Bladder and Urothelial Cancer Treatments
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Hematological disorders and diagnostics
- Immune Cell Function and Interaction
- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Orthopedic Infections and Treatments
- Nanoparticle-Based Drug Delivery
- Gout, Hyperuricemia, Uric Acid
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Inflammasome and immune disorders
Sun Yat-sen University
2016-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen Memorial Hospital
2016-2023
The purpose of the present study was to evaluate effects uric acid in promoting tubular cell apoptosis and verify role nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4)‑induced oxidative stress this process. HK‑2 cells were used as a human proximal model co‑cultured with various concentrations or without pre‑treatment Nox4 inhibitor diphenylene iodonium (DPI). apoptotic rate amount reactive oxygen species (ROS) examined by flow cytometry. Furthermore, levels Nox4, phosphorylated...
Abstract Resistance to anti–PD-1/PD-L1 treatment is often associated with accumulation of intratumoral inhibitory macrophages. V-domain immunoglobulin suppressor T-cell activation (VISTA) a nonredundant immune checkpoint that can induce both and myeloid-cell immunosuppression. In this study, we found high levels VISTA+ cells were advanced stage bladder cancer predicted poor survival in patients. A combination infiltration PD-L1+ or PD-1+ T the worst survival. Flow cytometry multiplex...
Sepsis is a complex disorder with high morality. Overabundant inflammation can result in organ dysfunction, leading to series of diseases. Drug delivery systems have improved drug efficacy and brought hope for sepsis treatment. However, the usage various inorganic organic carriers might increase potential toxicity nanoparticles (NPs) make their clinical transformation more difficult. Rhubarb epimedium show good anti-inflammation metabolic treatment potentials. A ingredients that form...
<p>Combination (combo) of VISTA mAb 13F3 with sODN-dsRNA induced TME changes in MB49 tumors</p>
<p>Flow cytometry gating strategy</p>
<p>Combination (combo) of VISTA mAb 13F3/sODN-dsRNA with TGF-β1mAb induced TME changes in MB49 mouse tumors</p>
<p>Identification of the cellular source VISTA in MB49 tumors.</p>
<p>Schematic diagram of sODN-dsRNA</p>
<div>Abstract<p>Resistance to anti–PD-1/PD-L1 treatment is often associated with accumulation of intratumoral inhibitory macrophages. V-domain immunoglobulin suppressor T-cell activation (VISTA) a nonredundant immune checkpoint that can induce both and myeloid-cell immunosuppression. In this study, we found high levels VISTA<sup>+</sup> cells were advanced stage bladder cancer predicted poor survival in patients. A combination infiltration...
<p>Combination (combo) of VISTA mAb 13F3 with sODN-dsRNA induced TME changes in MB49 tumors</p>
<p>Overall survival (OS) was analyzed with the Kaplan-Meier method stratifying 144 Cohort II UCB patients according to high or low levels of VISTA+ endothelial cells (ECs, A), tumor (TCs, B)</p>
<p>Flow cytometry gating strategy</p>