A5052214258- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Immune cells in cancer
- Bladder and Urothelial Cancer Treatments
- Mycobacterium research and diagnosis
- Immunotherapy and Immune Responses
- Hematological disorders and diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Plant-Microbe Interactions and Immunity
- Immune Cell Function and Interaction
- Plant Pathogens and Fungal Diseases
- Plant responses to water stress
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Orthopedic Infections and Treatments
- Transplantation: Methods and Outcomes
- Acute Myeloid Leukemia Research
- Photosynthetic Processes and Mechanisms
- Mycotoxins in Agriculture and Food
- Plant nutrient uptake and metabolism
- Plant Disease Resistance and Genetics
- Chemokine receptors and signaling
- Phytochemical compounds biological activities
- Acute Lymphoblastic Leukemia research
- Neutropenia and Cancer Infections
Sichuan Agricultural University
2024-2025
Hubei University
2024
Sun Yat-sen Memorial Hospital
2022-2024
Sun Yat-sen University
2022-2024
Zhejiang University
2024
Zhejiang Chinese Medical University
2024
Sir Run Run Shaw Hospital
2024
Background Interferons (IFNs) are essential for activating an effective immune response and play a central role in immunotherapy-mediated cell reactivation tumor regression. Type III IFN (λ), related to type I (α), plays crucial infections, autoimmunity, cancer. However, the direct effects of IFN-λ on microenvironment have not been thoroughly investigated. Methods We used mouse MB49 bladder models, constructed retroviral vector expressing IFN-λ3, transduced cells evaluate antitumor action...
Phytopathogens such as Puccinia striiformis f. sp. tritici (Pst) induce pigment retention at pathogen infection sites. Although is commonly observed in diverse pathosystems, its underlying physiological mechanism remains largely unclear. Herein, we identify and characterize a wheat leaf senescence gene, TaSGR1, which enhances resistance against Pst by promoting H2O2 accumulation while inhibiting photosynthesis. Knockout of TaSGR1 (STAYGREEN) increases plant susceptibility. Pst_TTP1...
Abstract Hydrogen sulfide (H 2 S) has emerged as a novel endogenous gas signaling molecule, joining the ranks of nitric oxide (NO) and carbon monoxide (CO). Recent research highlighted its involvement in various physiological processes, such promoting root organogenesis, regulating stomatal movement photosynthesis, enhancing plant growth, development, stress resistance. Tobacco, significant cash crop crucial for farmers’ economic income, relies heavily on development to affect leaf disease...
Chloroplasts are key players in photosynthesis and immunity against microbial pathogens. However, the precise timely regulatory mechanisms governing control of photosynthesis-associated nuclear genes (PhANGs) expression plant remain largely unknown. Here we report that TaPIR1, a Pst-induced RING-finger E3 ubiquitin ligase, negatively regulates Pst resistance by specifically interacting with TaHRP1, an atypical transcription factor histidine-rich protein. TaPIR1 ubiquitinates lysine residues...
Background: Although substantial efforts have been made by researchers to develop drugs, a disappointing reality is that the emergence of drug resistance an unavoidable for majority patients. In recent years, emerging evidence suggests connection between and immune dysregulation. Summary: As ubiquitously distributed, versatile innate cell, macrophages play essential roles in maintaining tissue homeostasis steady state. Nevertheless, it becoming aware undermine action therapeutic drugs across...
Abstract Resistance to anti–PD-1/PD-L1 treatment is often associated with accumulation of intratumoral inhibitory macrophages. V-domain immunoglobulin suppressor T-cell activation (VISTA) a nonredundant immune checkpoint that can induce both and myeloid-cell immunosuppression. In this study, we found high levels VISTA+ cells were advanced stage bladder cancer predicted poor survival in patients. A combination infiltration PD-L1+ or PD-1+ T the worst survival. Flow cytometry multiplex...
Fusarium is a soil-borne pathogen that poses serious threat to the quality and yield of hundreds crops worldwide, particularly tobacco production. Using metabolomics technology, we investigated natural metabolites from disease-conducting soil (DCS) disease-suppressing (DSS) rhizosphere as fungicides control wilt (TFW), which mainly caused by oxysporum . Furthermore, antifungal mechanisms these were preliminarily elucidated through various assessments, including activity determination,...
Tobacco Fusarium root rot is caused by various species, with eleven species reported, among which F. oxysporum and solani are main responsible in China (Yang et al., 2024). Notably, concentricum has not been previously reported until now at a global level tobacco. In June 2022, tobacco (Nicotiana tabacum L.) symptoms were observed fields (approximately 1500 m2) Xuanen County, Enshi City, Hubei Province (29.99°N, 109.44°E). About 20% of plants showed including dwarfing plants, chlorosis the...
<title>Abstract</title> Hydrogen sulfide (H<sub>2</sub>S) is a new endogenous gas signaling molecule alongside nitric oxide (NO) and carbon monoxide (CO). In recent years, many studies have shown that it involved in variety of physiological activities, promoting root organogenesis, regulating stomatal movement photosynthesis, playing an important role plant growth development improving the stress resistance Plants can play. Tobacco special cash crop whose usually determines economic income...
Lymphoma relapse is very common in clinical work, but lineage switch at rare. Although some cases have reported acute lymphocytic leukemia (ALL) to myeloid (AML) or sarcoma upon relapse, phenotype seldom occurs other types of lymphoma. Here we report six with from lymphoma neoplasms. In our cohort, three were mantle cell (MCL), and the T-cell lymphoblastic (T-LBL), B-cell (B-LBL), diffuse large (DLBCL) initial diagnosis. When linage occurred, most AML M5 phenotypes, only one case was...
<p>Combination (combo) of VISTA mAb 13F3 with sODN-dsRNA induced TME changes in MB49 tumors</p>
<p>Flow cytometry gating strategy</p>
<p>Combination (combo) of VISTA mAb 13F3/sODN-dsRNA with TGF-β1mAb induced TME changes in MB49 mouse tumors</p>