A5045844391- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Developmental Biology and Gene Regulation
- Fibroblast Growth Factor Research
- Blood Coagulation and Thrombosis Mechanisms
- Reproductive Physiology in Livestock
- Reproductive System and Pregnancy
- Hypothalamic control of reproductive hormones
- Epigenetics and DNA Methylation
- Peroxisome Proliferator-Activated Receptors
- Cancer-related Molecular Pathways
- Protease and Inhibitor Mechanisms
- Renal and related cancers
University of Helsinki
2022-2024
Czech Academy of Sciences, Institute of Biotechnology
2023-2024
Tissue Dynamics (Israel)
2023-2024
University of Warmia and Mazury in Olsztyn
2019
Medical University of Warsaw
2006
The mammary gland is a unique organ that undergoes dynamic alterations throughout female's reproductive life, making it an ideal model for developmental, stem cell and cancer biology research. Mammary development begins in utero proceeds via quiescent bud stage before the initial outgrowth subsequent branching morphogenesis. How epithelial cells transit from quiescence to actively proliferating tissue during embryogenesis and, importantly, how branch pattern determined remain largely...
Branching morphogenesis is an evolutionary solution to maximize epithelial function in a compact organ. It involves successive rounds of branch elongation and point formation generate tubular network. In all organs, points can form by tip splitting, but it unclear how cells coordinate branching. Here, we addressed these questions the embryonic mammary gland. Live imaging revealed that tips advance directional cell migration relies upon differential motility feeds retrograde flow lagging into...
Branching morphogenesis is a characteristic feature of many essential organs, such as the lung and kidney, most glands, net result two tissue behaviors: branch point initiation elongation. Each branched organ has distinct architecture customized to its physiological function, but how patterning occurs in these ramified tubular structures fundamental problem development. Here, we use quantitative 3D morphometrics, time-lapse imaging, manipulation ex vivo cultured mouse embryonic organs mice...
Abstract Mammary gland is a unique organ that undergoes dynamic alterations throughout female’s reproductive life, making it an ideal model for developmental, stem cell and cancer biology research. development begins in utero proceeds via quiescent bud stage before the initial outgrowth subsequent branching morphogenesis. How mammary epithelial cells transit from quiescence to actively proliferating tissue during embryogenesis and, importantly, how branch pattern determined remain largely...
Following previous editions, the fifteenth annual workshop of European Network for Breast Development and Cancer (ENBDC) on Methods in Mammary Gland Biology was held from 2nd to 4th May Weggis, Switzerland. Over course this meeting, participants followed discussed presentations a roster internationally renowned invited speakers selected abstracts, complemented with two poster sessions covering exciting unpublished results. The covered projects normal mammary gland development, breast cancer...
Abstract Branching morphogenesis is a characteristic feature of many essential organs such as the lung, kidney, and most glands, net result two tissue behaviors: branch point initiation elongation. Each branched organ has distinct architecture customized to its physiological function, but how patterning occurs in these ramified tubular structures fundamental problem development. Here we use quantitative 3D morphometrics, time-lapse imaging, manipulation ex vivo cultured embryonic organs,...
Abstract Branching morphogenesis is the common evolutionary solution of multiple organs to combine maximal epithelial function with compact organ size. It involves successive rounds branch elongation and point generation generate a branched network. Branch points form most commonly at tips branches as they split into two. However, it unclear how cells in drive both branching. In this study, we used ex vivo live imaging identify these fundamental cellular mechanisms embryonic mammary gland....