A5090451254- dental development and anomalies
- Bone and Dental Protein Studies
- Cancer Cells and Metastasis
- Genomics and Chromatin Dynamics
- Molecular Biology Techniques and Applications
- Forensic Anthropology and Bioarchaeology Studies
- Bone Metabolism and Diseases
- Cancer-related gene regulation
- Fibroblast Growth Factor Research
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Cleft Lip and Palate Research
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- RNA Research and Splicing
- Growth Hormone and Insulin-like Growth Factors
- RNA and protein synthesis mechanisms
- Oral and Maxillofacial Pathology
Helsinki Institute of Physics
2019-2024
University of Helsinki
2017-2024
Czech Academy of Sciences, Institute of Biotechnology
2019-2024
Tissue Dynamics (Israel)
2023-2024
The mammary gland is a unique organ that undergoes dynamic alterations throughout female's reproductive life, making it an ideal model for developmental, stem cell and cancer biology research. Mammary development begins in utero proceeds via quiescent bud stage before the initial outgrowth subsequent branching morphogenesis. How epithelial cells transit from quiescence to actively proliferating tissue during embryogenesis and, importantly, how branch pattern determined remain largely...
When a null mutation of gene causes complete developmental arrest, the is typically considered essential for life. Yet, in most cases, mutations have more subtle effects on phenotype. Here we used phenotypic severity as tool to examine system-level dynamics expression. We classify genes required normal development mouse molar into different categories that range from modification Collectively, call these keystone genes. Transcriptome profiling using microarray and RNAseq analyses patterning...
When evolution leads to differences in body size, organs generally scale along. A well-known example of the tight relationship between organ and size is scaling mammalian molar teeth. To investigate how teeth during development evolution, we compared from initiation through final mouse rat. Whereas linear dimensions rat molars are twice that molars, their shapes largely same. Here, focus on first lower considered most reliable dental proxy for size-related patterns due low within-species...
Abstract Mammary gland is a unique organ that undergoes dynamic alterations throughout female’s reproductive life, making it an ideal model for developmental, stem cell and cancer biology research. development begins in utero proceeds via quiescent bud stage before the initial outgrowth subsequent branching morphogenesis. How mammary epithelial cells transit from quiescence to actively proliferating tissue during embryogenesis and, importantly, how branch pattern determined remain largely...
Abstract Based on his analyses of lynx and brown bear teeth, Björn Kurtén coined the concept ‘realisation threshold’, smallest size at which a tooth can form erupt properly. found sizes studied teeth to be 2.5 mm 3.5 mm, respectively, much larger than for example rodent known readily erupt. A recent study comparing developing from shrews elephants suggested relatively unchanged theoretical minimum mammalian teeth. Together, these studies have left open question whether realisation thresholds...
Based on his analyses of lynx and brown bear teeth, Björn Kurtén coined the concept 'realisation threshold', smallest size at which a tooth can form erupt properly. found sizes studied teeth to be 2.5 mm 3.5 mm, respectively, much greater than for example rodent known readily erupt. A recent study comparing developing from shrews elephants suggested relatively unchanged theoretical minimum mammalian teeth. Together, these studies have left open question whether realisation thresholds are...
High resolution and noninvasiveness have made soft-tissue X-ray microtomography (µCT) a widely applicable three-dimensional (3D) imaging method in studies of morphology development. However, scarcity molecular probes to visualize gene activity with µCT has remained challenge. Here, we apply horseradish peroxidase–assisted reduction silver catalytic gold enhancement the deposit situ hybridization order detect expression developing tissues (here called GECT, CT). We show that GECT detects...
Although most genes share their chromosomal neighbourhood with other genes, distribution of has not been explored in the context individual organ development; common focus developmental biology studies. Because processes are often associated initially subtle changes gene expression, here we whether neighbouring informative identification differentially expressed genes. First, quantified patterns having related functional roles mammalian genome. majority protein coding have at least five...
Abstract When a null mutation of gene causes complete developmental arrest, the is typically considered essential for life. Yet, in most cases mutations have more subtle effects on phenotype. Here we used phenotypic severity as tool to examine system-level dynamics expression. We classify genes required normal development mouse molar into different categories that range from modification Collectively, call these keystone genes. Transcriptome profiling using microarray and RNAseq analyses...
ABSTRACT When evolution leads to differences in body size, organs generally scale along. A well-known example of the tight relationship between organ and size is scaling mammalian molar teeth. To investigate how teeth during development evolution, we compared mouse rat from initiation through final size. Whereas linear dimensions first lower are twice that molar, their shapes largely same. We found molars starts early, patterned equally as fast but a larger than molar. Using transcriptomics,...
Continuously growing teeth are an important innovation in mammalian evolution, yet genetic regulation of continuous growth by stem cells remains incompletely understood. Dental responsible for tooth crown lost at the onset root formation. Genetic signaling that initiates this loss is difficult to study with ever-growing incisor and rooted molars mice, most common dental model species, because signals formation overlap pattern size shape (i.e., cusp patterns). Different species voles...
ABSTRACT Although most genes share their chromosomal neighbourhood with other genes, distribution of has not been explored in the context individual organ development; common focus developmental biology studies. Because processes are often associated initially subtle changes gene expression, here we whether neighbouring informative identification differentially expressed genes. First, quantified patterns having related functional roles mammalian genome. majority protein coding have at least...
Abstract High resolution and noninvasiveness have made soft tissue X-ray microtomography (µCT) a widely applicable three-dimensional (3D) imaging method in studies of morphology development. However, scarcity molecular probes to visualize gene activity with µCT has remained challenge. Here we apply horseradish peroxidase -assisted reduction silver catalytic gold enhancement the deposit situ hybridization order detect expression developing tissues (here called GECT, Gene Expression CT). We...