A5065360130- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Hearing Loss and Rehabilitation
- Wnt/β-catenin signaling in development and cancer
- Studies on Chitinases and Chitosanases
- Cellular transport and secretion
- Noise Effects and Management
- Signaling Pathways in Disease
- Neuroscience and Music Perception
- Fibroblast Growth Factor Research
- Autism Spectrum Disorder Research
- Language Development and Disorders
- Calpain Protease Function and Regulation
- Advanced Adaptive Filtering Techniques
- Vestibular and auditory disorders
- Behavioral and Psychological Studies
- Multisensory perception and integration
- Nerve injury and regeneration
- Neurobiology of Language and Bilingualism
- Cellular and Composite Structures
- Hearing, Cochlea, Tinnitus, Genetics
- Transgenic Plants and Applications
- Developmental Biology and Gene Regulation
- Peptidase Inhibition and Analysis
University of Helsinki
2009-2024
Czech Academy of Sciences, Institute of Biotechnology
2009-2024
Tissue Dynamics (Israel)
2023-2024
Palo Alto University
2009
Stanford University
2009
Beijing Institute of Optoelectronic Technology
2006
Arizona State University
1975-1976
In vertebrates the development and function of nervous system is regulated by neurotrophic factors (NTFs). Despite extensive searches no have been found in invertebrates. However, cell ablation studies Drosophila suggest trophic interaction between neurons glia. Here we report invertebrate factor Drosophila, DmMANF, homologous to mammalian MANF CDNF. DmMANF expressed glia essential for maintenance dopamine positive neurites levels. The abolishment both maternal zygotic leads degeneration...
The mammary gland is a unique organ that undergoes dynamic alterations throughout female's reproductive life, making it an ideal model for developmental, stem cell and cancer biology research. Mammary development begins in utero proceeds via quiescent bud stage before the initial outgrowth subsequent branching morphogenesis. How epithelial cells transit from quiescence to actively proliferating tissue during embryogenesis and, importantly, how branch pattern determined remain largely...
MANF and CDNF are evolutionarily conserved neurotrophic factors that specifically support dopaminergic neurons. To date, the receptors signalling pathways of this novel MANF/CDNF family have remained unknown. Independent studies showed upregulation by unfolded protein response (UPR). enlighten role in multicellular organism development we carried out a microarray-based analysis transcriptional changes induced loss overexpression Drosophila Manf. The most dramatic change expression was...
Disturbances in the homeostasis of endoplasmic reticulum (ER) referred to as ER stress is involved a variety human diseases. activates unfolded protein response (UPR), cellular mechanism purpose which restore homeostasis. Previous studies show that Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) an important novel component regulation UPR. In vertebrates, MANF upregulated by and protects cells against stress-induced cell death. Biochemical have revealed interaction between...
Mammalian MANF and CDNF proteins are evolutionarily conserved neurotrophic factors that can protect repair mammalian dopaminergic neurons in vivo. In Drosophila, the sole protein (DmManf) is needed for maintenance of neurites dopamine levels. Although both secreted intracellular roles have been demonstrated, very little known about molecular mechanism their action. Here, by using a transgenic rescue approach DmManf mutant background we show only full-length containing amino-terminal...
Branching morphogenesis is a characteristic feature of many essential organs, such as the lung and kidney, most glands, net result two tissue behaviors: branch point initiation elongation. Each branched organ has distinct architecture customized to its physiological function, but how patterning occurs in these ramified tubular structures fundamental problem development. Here, we use quantitative 3D morphometrics, time-lapse imaging, manipulation ex vivo cultured mouse embryonic organs mice...
The mammary gland develops from the surface ectoderm during embryogenesis and proceeds through morphological phases defined as placode, hillock, bud, bulb stages followed by branching morphogenesis. During this early morphogenesis, bud undergoes an invagination process where thickened initially protrudes above epithelium then transforms to a sinks into underlying mesenchyme. signaling pathways regulating morphogenetic steps have been identified some extent, but cellular mechanisms remain ill...
Abstract Mammary gland is a unique organ that undergoes dynamic alterations throughout female’s reproductive life, making it an ideal model for developmental, stem cell and cancer biology research. development begins in utero proceeds via quiescent bud stage before the initial outgrowth subsequent branching morphogenesis. How mammary epithelial cells transit from quiescence to actively proliferating tissue during embryogenesis and, importantly, how branch pattern determined remain largely...
Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) and Cerebral Dopamine (CDNF) form an evolutionarily conserved family of neurotrophic factors. Orthologues for MANF/CDNF are the only factors as yet identified in invertebrates with amino acid sequence. Previous studies indicate that mammalian MANF CDNF support protect brain dopaminergic system non-cell-autonomous manner. However, has also been shown to function intracellularly endoplasmic reticulum. To date, knowledge on interacting...
Abstract Branching morphogenesis is a characteristic feature of many essential organs such as the lung, kidney, and most glands, net result two tissue behaviors: branch point initiation elongation. Each branched organ has distinct architecture customized to its physiological function, but how patterning occurs in these ramified tubular structures fundamental problem development. Here we use quantitative 3D morphometrics, time-lapse imaging, manipulation ex vivo cultured embryonic organs,...
Frequency selectivity in ears suffering sensorineural hearing deficits was assessed using a tone-on-tone masking paradigm. Psychophysical tuning curves relating level of continuous tonal masker required to just mask probe constant frequency and intensity the were obtained for several normal impaired ears. In agreement with recent observation Vogten (in Facts Models Hearing, E. Zwicker Terhardt, Eds.), high-level probes (≃70 dB SPL) psychophysical displayed well-defined minima (corresponding...
For listeners with hearing loss due to cochlear damage, we have shown that in frequency regions displaying threshold elevation, there is a marked alteration the psychophysical tuning curve [J. Acoust. Soc. Am. 58, S71 (A) (1975)]. Of major importance was observation of complete disappearance low-threshold finely tuned segment cochlea damage. In vicinity probe, contrast normal curve, effectiveness masker sharply diminished. The “notch” has now been confirmed several having various types...