A5072962006- Mosquito-borne diseases and control
- Advanced Proteomics Techniques and Applications
- Pluripotent Stem Cells Research
- Cellular transport and secretion
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Receptor Mechanisms and Signaling
- Extracellular vesicles in disease
- Bioinformatics and Genomic Networks
Universidade Estadual de Campinas (UNICAMP)
2016-2019
Schizophrenia is a complex neuropsychiatric disorder, involving genetic and environmental factors.The disease results in range of symptoms it related to changes during neurodevelopment.Therefore, the use neural progenitor cells (NPCs) an attractive model better understand molecular mechanisms from this disorder.We performed proteomic analysis secretome obtained NPC's culture media, patients with schizophrenia mentally healthy controls.In our results, we found proteins associated signaling...
Exosomes are cell-derived nano vesicles that play multiple roles as mediate cellular communication, elimination of undesirable components and transport molecules such RNAs proteins.Misfolded proteins associated to the development pathologies may be also transported by exosomes.This study aims perform a quantitative proteome analysis exosomes collected from cell cultures derived patients with schizophrenia mentally healthy controls, in order find differentially expressed possibly disease.
The Brazilian outbreak of the Zika virus (ZIKV) in 2015 was accompanied by an increase number cases microcephaly, which involves severe changes brain development, indicating a possible association between viral infection with these cerebral malformations. molecular mechanisms that promote modifications have not been fully understood. In order to do so, vitro models using human induced pluripotency stem cells (hiPSC), differentiated into neural cells, are being studied as model...