A5018201876- Diet and metabolism studies
- Nutritional Studies and Diet
- Peptidase Inhibition and Analysis
- Metabolomics and Mass Spectrometry Studies
- Sensor Technology and Measurement Systems
- Cardiovascular Effects of Exercise
- Iron Metabolism and Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Endoplasmic Reticulum Stress and Disease
- Genetics and Neurodevelopmental Disorders
- Time Series Analysis and Forecasting
- Obesity, Physical Activity, Diet
- Advanced Proteomics Techniques and Applications
- Plant Pathogenic Bacteria Studies
- Liver Disease Diagnosis and Treatment
- Chronic Disease Management Strategies
- Ubiquitin and proteasome pathways
- Pesticide Residue Analysis and Safety
- Metabolism and Genetic Disorders
- Insect-Plant Interactions and Control
- Cardiac electrophysiology and arrhythmias
- Aortic Disease and Treatment Approaches
- Mass Spectrometry Techniques and Applications
- Phytoplasmas and Hemiptera pathogens
- Aortic aneurysm repair treatments
Institute for Biomedicine
2021-2024
Eurac Research
2021-2024
Public Limited Company for Radioactive Waste Management
2020
University of Trento
2017-2018
The Microsoft Research - University of Trento Centre for Computational and Systems Biology
2017-2018
Metabolomics in human serum samples provide a snapshot of the current metabolic state an individuum. Metabolite concentrations are influenced by both genetic and environmental factors. Concentrations certain metabolites can further depend on age, sex, menopause, diet study participants. A better understanding these relationships is pivotal for planning metabolomics studies involving subjects interpretation their results. We generated one largest single-site targeted data sets consisting 175...
The domesticated dog, Canis lupus familiaris, has been selectively bred to produce extreme diversity in phenotype and genotype. Dogs have an immense weight height. Specific differences metabolism not characterized small dogs as compared larger dogs.This study aims identify metabolic, clinical, microbiota between dogs.Gas chromatography/mass spectrometry, liquid chromatography/tandem mass clinical chemistry analysis, dual-energy X-ray absorptiometry, 16S pyrosequencing were used characterize...
Abstract Background The study of circulating blood proteins in population cohorts offers new avenues to explore lifestyle-related and genetic influences describing shaping human health. Methods Utilizing high-throughput mass spectrometry, we quantified 148 highly abundant proteins, functioning the innate adaptive immune system, coagulation nutrient transport 3632 plasma, 500 serum samples from CHRIS BASE-II cross-sectional studies, respectively. Through multiple regression analyses, aimed...
Abstract Background Plasma proteomics offers new avenues to explore non-genetic associations, such as biomarkers for lifestyle and environmental exposure in population studies. To date, most proteomic investigations studies have utilized affinity-reagent based technologies, which are ideal quantify the low abundant fraction of circulating proteome but may omit several proteins that function plasma. Methods Utilizing high throughput mass spectrometry, we quantified 148 highly protein groups...
Atrial fibrillation (AF) is a supraventricular arrhythmia deriving from uncoordinated electrical activation with considerable associated morbidity and mortality. To expand the limited understanding of AF biological mechanisms, we performed two screenings, investigating genetic metabolic determinants in Cooperative Health Research South Tyrol study. We found 110 cases out 10,509 general population individuals. A genome-wide association scan (GWAS) identified novel loci (p-value < 5 × 10−8)...
In longitudinal clinical studies, methodologies available for the analysis of multivariate data with methods are relatively limited. Here, we present Consensus Clustering (CClust) a new computational method based on clustering time profiles and posterior identification correlation between clusters predictors. Subjects first clustered in groups according to response variable temporal profile, using robust consensus-based strategy. To discover which remaining variables associated resulting...
Abstract Genome-wide association studies identified a locus on chromosome 4q21.1, spanning the FAM47E , STBD1 CCDC158 and SHROOM3 genes, as associated with kidney function markers. Functional implicated encoding an actin-binding protein involved in cell shaping, into podocyte barrier damage. Despite was also found electrolytes, hematological cardiovascular traits, systematic explorations of functional variants across all genes are lacking. We reconstructed haplotypes covering whole 12,834...
Abstract Identifying biomarkers able to discriminate individuals on different health trajectories is crucial understand the molecular basis of age-related morbidity. We investigated multi-omics signatures general and organ-specific morbidity, as well their interconnectivity. examined cross-sectional metabolome proteome data from 3,142 adults Cooperative Health Research in South Tyrol (CHRIS) study, an Alpine population study designed investigate how human biology, environment, lifestyle...
Identifying biomarkers able to discriminate individuals on different health trajectories is crucial understand the molecular basis of age-related morbidity. We investigated multi-omics signatures general and organ-specific morbidity, as well their interconnectivity. examined cross-sectional metabolome proteome data from 3,142 adults Cooperative Health Research in South Tyrol (CHRIS) study, an Alpine population study designed investigate how human biology, environment, lifestyle factors...
Apple proliferation is associated with the presence of bacterium ‘Candidatus Phytoplasma mali’. An infection this pathogen leads to changes physiological state apple tree. In study, it was applied near-infrared spectroscopy measure these changes. preliminary analysis based on a quadratic discriminant first indications that might be possible discriminate diseased from uninfected sample material were achieved.
In dieser Arbeit wurden anhand von Daten aus den Jahren 1991-2018 Trocknungsfaktoren für sieben in Südtirol angebaute Kräuterarten bestimmt und mit Werten der Literatur verglichen. Anhand diesen können Referenzwerte die Berechnung zulässigen Rückstandsgehalte Kräuter im getrockneten Zustand bereitgestellt werden. Um Einfluss Probennahme Reproduzierbarkeit Rückstandsanalysen bei einer Kräutermischung zu untersuchen, eine Reihe an kommerziellen extra gemahlenen Proben Mischung neun...
U radu su predstavljeni konvencionalni i elektronski transformatori izvršeno je njihovo poređenje, predstavljena njihova analiza prema zapremini, težini ceni. Nakon predstavljanja osnovnih topologija elektronskih transformatora prikazanih modela za svaku kategoriju topologije, opisana primena u obnovljim izvorima energije, vučnim sistemima punjačima električnih automobile. Na kraju problemi izazovi budućeg razvoja transformatora.