A5047024251- Bacteriophages and microbial interactions
- Sphingolipid Metabolism and Signaling
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Respiratory viral infections research
- DNA and Nucleic Acid Chemistry
- Nanoparticle-Based Drug Delivery
The University of Texas at Dallas
2017-2018
Proteinaceous nanomaterials and, in particular, virus-like particles (VLPs) have emerged as robust and uniform platforms that are seeing wider use biomedical research. However, there a limited number of bioconjugation reactions for functionalizing the capsids, very few those involve functionalization across supramolecular quaternary structure protein assemblies. In this work, we exploit recently described dibromomaleimide moiety part strategy on VLP Qβ to break rebridge exposed structurally...
Controlling the uptake of nanomaterials into phagocytes is a challenging problem. We describe an approach to inhibit cellular by macrophages and HeLa cells nanoparticles derived from bacteriophage Qβ conjugating negatively charged terminal hexanoic acid moieties onto its surface. Additionally, we show hydrazone linkers can be installed between surface moieties, resulting in pH-responsive conjugate that, acidic conditions, release moiety allow for nanoparticle. The installation "pH switch"...