Vaccines have an innate tendency to lose their structural conformation upon environmental and chemical stressors. A loss in reduces the therapeutic ability prevent spread of a pathogen. Herein, we report in-depth study zeolitic imidazolate framework-8 its provide protection for model viral vector against denaturing conditions. The immunoassay spectroscopy analysis together demonstrate enhanced thermal stability conformational structure encapsulated nanoparticle. long-term biological activity...

Metal-organic frameworks (MOFs) are promising high surface area coordination polymers with tunable pore structures and functionality; however, a lack of good size morphological control over the as-prepared MOFs has persisted as an issue in their application. Herein, we show how robust protein template, tobacco mosaic virus (TMV), can be used to regulate shape as-fabricated MOF materials. We were able obtain discrete rod-shaped TMV@MOF core-shell hybrids uniformity, diameters could tuned by...

Biomimetic mineralization with metal–organic frameworks (MOF), typically zeolitic imidazolate framework-8 (ZIF-8), is an emerging strategy to protect sensitive biological substances against denaturing environmental stressors such as heat and proteolytic agents. Additionally, this same biomimetic process has the potential of being used create distinct core–shell architectures using genetically or chemically modified viral nanoparticles. Despite proliferation examples for ZIF-8 growth on...

Solid-state thermoelastic behavior—a sudden exertion of an expansive or contractive physical force following a temperature change and phase transition in solid-state compound—is rare organic crystals, few are reversible systems, most these limited to dozen so cycles before the crystal degrades they reverse slowly over course many minutes even hours. Comparable thermosalience, wherein changes induce energetic jumping, thermomorphism produces work via consistent near-instantaneous predictable...

Superoxide overproduction is known to occur in multiple disease states requiring critical care; yet, noninvasive detection of superoxide deep tissue remains a challenge. Herein, we report metal-free magnetic resonance imaging (MRI) and electron paramagnetic (EPR) active contrast agent prepared by "click conjugating" organic radical agents (ORCAs) the surface tobacco mosaic virus (TMV). While ORCAs are be reduced vivo an MRI/EPR silent state, their oxidation facilitated specifically reactive...

We report thermo-mechanically responsive and thermochromic behavior in the single crystalline organic semiconductor butoxyphenyl N-substituted naphthalene diimide (BNDI). show that initially monoclinic crystals of BNDI undergo a single-crystal to transition triclinic phase. This accompanies large changes crystal packing, visible decrease size, reversible behavior, motion including bending, jumping, splitting. have shown by fixing surface, we can harness energy phase create cantilever capable...

Abstract Metal–organic frameworks (MOFs) are promising high surface area coordination polymers with tunable pore structures and functionality; however, a lack of good size morphological control over the as‐prepared MOFs has persisted as an issue in their application. Herein, we show how robust protein template, tobacco mosaic virus (TMV), can be used to regulate shape as‐fabricated MOF materials. We were able obtain discrete rod‐shaped TMV@MOF core–shell hybrids uniformity, diameters could...

Proteinaceous nanomaterials and, in particular, virus-like particles (VLPs) have emerged as robust and uniform platforms that are seeing wider use biomedical research. However, there a limited number of bioconjugation reactions for functionalizing the capsids, very few those involve functionalization across supramolecular quaternary structure protein assemblies. In this work, we exploit recently described dibromomaleimide moiety part strategy on VLP Qβ to break rebridge exposed structurally...

Controlling the uptake of nanomaterials into phagocytes is a challenging problem. We describe an approach to inhibit cellular by macrophages and HeLa cells nanoparticles derived from bacteriophage Qβ conjugating negatively charged terminal hexanoic acid moieties onto its surface. Additionally, we show hydrazone linkers can be installed between surface moieties, resulting in pH-responsive conjugate that, acidic conditions, release moiety allow for nanoparticle. The installation "pH switch"...

A new class of semi-conducting boron carbide polymers has been formed from cross-linking ortho -carborane ( o -B 10 C 2 H 12 ) or o- B in the presence aromatic compounds (Y =1,4-diaminobenzene, pyridine, and benzene) to form X :Y, respectively. Core valence band photoemission molecular orbital calculations indicate that results site-specific bonding between sites opposite carbon on carborane icosahedra. This site specificity is retained when linking units; units insert themselves insertion...

<div><div><div><p>Vaccines have an innate tendency to lose their structural conformation upon environmental and chemical stressors. A loss in reduces the therapeutic ability prevent spread of a pathogen. Herein, we report in-depth study zeolitic imidazolate framework-8 (ZIF-8) its provide protection for model viral vector against dena- turing conditions. The immunoassay spectroscopy analysis together demonstrate enhanced thermal stability conformational structure...

Superoxide overproduction is known to occur in multiple disease states requiring critical care yet non-invasive detection of superoxide deep tissue remains a challenge. Herein, we report metal-free magnetic resonance imaging (MRI) and electron paramagnetic (EPR) active contrast agent prepared by “click conjugating” organic radical agents (ORCAs) the surface tobacco mosaic virus (TMV). While ORCAs are be reduced <i>in vivo</i> an MRI/EPR silent state, their oxidation facilitated...

Superoxide overproduction is known to occur in multiple disease states requiring critical care yet non-invasive detection of superoxide deep tissue remains a challenge. Herein, we report metal-free magnetic resonance imaging (MRI) and electron paramagnetic (EPR) active contrast agent prepared by “click conjugating” organic radical agents (ORCAs) the surface tobacco mosaic virus (TMV). While ORCAs are be reduced vivo an MRI/EPR silent state, their oxidation facilitated specifically reactive...

Solid state thermosalience—a sudden exertion of an expansive or contractive physical force following a temperature change in solid compound—is rare, few are reversible systems, and most these limited to dozen so cycles before the crystal degrades they reverse slowly over course many minutes even hours. In this work, we show fully actuator that is stable at room for multiple years capable actuation more than two hundred near ambient temperature. Specifically, crystals shrink 90% its original...

Solid state thermosalience—a sudden exertion of an expansive or contractive physical force following a temperature change in solid compound—is rare, few are reversible systems, and most these limited to dozen so cycles before the crystal degrades they reverse slowly over course many minutes even hours. In this work, we show fully actuator that is stable at room for multiple years capable actuation more than two hundred near ambient temperature. Specifically, crystals shrink 90% its original...

Abstract not Available.

Mechanically responsive materials exhibit significant structural changes due to external stimuli such as light, heat and mechanical forces.These are widely used actuators in energy harvesting applications.Herein, we report that the monoclinic polymorph (M-phase) of organic semiconductor butoxyphenyl N-substituted naphthalene diimide undergoes clean complete polymorphic SC-SC phase transition its highly thermochromic triclinic (T-phase) upon heating.

Vaccines have an innate tendency to lose their structural conformation upon environmental and chemical stressors. A loss in reduces the therapeutic ability prevent spread of a pathogen. Herein, we report in-depth study zeolitic imidazolate framework-8 (ZIF-8) its provide protection for model viral vector against dena- turing conditions. The immunoassay spectroscopy analysis together demonstrate enhanced thermal stability conformational structure encapsulated nanoparticle. long-term...

Solid state thermosalience—a sudden exertion of an expansive or contractive physical force following a temperature change in solid compound—is rare, few are reversible systems, and most these limited to dozen so cycles before the crystal degrades they reverse slowly over course many minutes even hours. In this work, we show fully actuator that is stable at room for multiple years capable actuation more than two hundred near ambient temperature. Specifically, crystals shrink 90% its original...