Exosomes have recently appeared as a novel source of non-invasive cancer biomarkers since tumour-specific molecules can be found in exosomes isolated from biological fluids. We here investigated the proteome urinary by using mass spectrometry to identify proteins differentially expressed prostate patients compared healthy male controls. In total, 15 control and 16 samples were analyzed. Importantly, 246 two groups. The majority these (221) up-regulated patients. These analyzed according...

The hypoxia marker pimonidazole is a candidate biomarker of cancer aggressiveness. We investigated the transcriptional programme associated with staining in prostate cancer. Index tumour biopsies were taken by image guidance from an investigation cohort 52 patients, where 43 patients received before prostatectomy. Biopsy location within index was verified for 46 (88%) who included gene expression profiling and immunohistochemistry. Two independent cohorts 59 281 used validation. Expression...

To explore the predictive value of MRI parameters and tumour characteristics before neoadjuvant chemotherapy (NAC) to compare changes in size apparent diffusion coefficient (ADC) during treatment, between patients who achieved pathological complete response (pCR) those did not. Approval by Regional Ethics Committee written informed consent were obtained. Thirty-one with invasive breast carcinoma scheduled for NAC enrolled (mean age, 50.7; range, 37–72). Study design included treatment (Tp0),...

Background. For patients with locally advanced breast cancer (LABC) undergoing neoadjuvant chemotherapy (NACT), the European Guidelines for Breast Imaging recommends magnetic resonance imaging (MRI) to be performed before start of NACT, when half NACT has been administered and prior surgery. This is first study addressing value flow-insensitive apparent diffusion coefficients (ADCs) obtained from diffusion-weighted (DW) MRI at recommended time points pretreatment prediction monitoring...

Abstract The established role of hypoxia-induced signaling in prostate cancer growth, metastasis, and response to treatment suggests that a method image hypoxia tumors could aid decisions. Here, we present consumption supply-based (CSH) imaging, an approach integrates images related oxygen supply into single image. This integration algorithm was developed patients with receiving marker pimonidazole prior prostatectomy. We exploited the intravoxel incoherent motion (IVIM) signal diagnostic...

The previously reported SECA study demonstrated a dramatic 5-year survival improvement in patients with unresectable colorectal liver metastases (CLM) treated transplantation (LT) compared chemotherapy. objective of this was to assess whether immunosuppressive therapy accelerates the growth pulmonary transplanted for CLM.Chest CT scans from 11 resected 18 were reviewed retrospectively. Tumour diameter, volume and characteristics registered tumour doubling time calculated. Findings group...

Background 18F fluoro-deoxyglucose (FDG) positron emission tomography / computed (PET/CT) is a well-recognized diagnostic tool used for staging and monitoring of therapy response lymphomas. During the past decade diffusion-weighted (DW) magnetic resonance imaging (MRI) increasingly being included in assessment tumor various cancers. Purpose To compare change maximum standardized uptake value (ΔSUVmax) from FDG PET/CT with apparent diffusion coefficient (ΔADC) DW MRI after initiation first...

In locally advanced rectal cancer (LARC), responses to preoperative treatment are highly heterogeneous and more accurate diagnostics likely enable individualised approaches with improved responses. We investigated the potential of diffusion-weighted magnetic resonance imaging (DW MRI), quantification apparent diffusion coefficient (ADC) perfusion fraction (F), as well volumetry from T2-weighted (T2W) MRI, for prediction therapeutic outcome.In 27 LARC patients receiving neoadjuvant...

Abstract Objective High rates of systemic failure in locally advanced rectal cancer call for a rational use conventional therapies to foster tumor-defeating immunity. Methods We analyzed the high-mobility group box-1 (HMGB1) protein, measure immunogenic cell death (ICD), plasma sampled from 50 patients at time diagnosis and following 4 weeks induction chemotherapy 5 sequential chemoradiotherapy, both neoadjuvant modalities containing oxaliplatin. The had residual tumor resected were followed...

Tumor delineation is time- and labor-intensive prone to inter- intraobserver variations. Magnetic resonance imaging (MRI) provides good soft tissue contrast, functional MRI captures properties that may be valuable for tumor delineation. We explored MRI-based automatic segmentation of rectal cancer using a deep learning (DL) approach. first investigated potential improvements when including both anatomical T2-weighted (T2w) diffusion-weighted MR images (DWI). Secondly, we generalizability by...

Journal Article Doses to nuclear technicians in a dedicated PET/CT centre utilising 18F fluorodeoxyglucose (FDG) Get access T. Seierstad, Seierstad *Corresponding author: erling.stranden@hibu.no Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Stranden, Stranden K. Bjering, Bjering M. Evensen, Evensen A. Holt, Holt H. Michalsen, Michalsen O. Wetteland Radiation Protection Dosimetry, Volume 123, Issue 2, February 2007, Pages 246–249,...

Reject analysis can be used as a quality indicator, and is an important tool in localizing areas where optimization required. Reducing number of rejects yielding reduced patient exposure increased cost-effectiveness.To determine rejection rates causes direct digital radiography.Data were collected during three-month period spring 2010 at two laboratories Norway. All X-ray examinations, types, numbers, reasons for rejections obtained using automatic reject software. Thirteen could...

There is currently no consensus on the methodology for quantification of

This study was conducted in order to elucidate metabolic differences between human rectal cancer biopsies and colorectal HT29, HCT116 SW620 xenografts by using high-resolution magnetic angle spinning (MAS) resonance spectroscopy (MRS) for determination of the most appropriate xenograft model preclinical MR studies. A further aim investigate changes following irradiation HT29 xenografts. HR MAS MRS tissue samples from were obtained with a Bruker Avance DRX600 spectrometer analyzed principal...

Introduction. Dynamic 18F-FDG PET allows the study of glucose distribution in tissues as a function time and space. Using pharmacokinetics, temporal uptake pattern may be separated into components reflecting perfusion metabolism. Bevacizumab is an angiogenesis inhibitor which prevents growth new blood vessels, potentially lead to normalization circulation tumor. The purpose was explore use dynamic tool for monitoring treatment effect, reflected by changes Materials Methods. Twelve athymic...

To explore how apparent diffusion coefficients (ADCs) in malignant breast lesions are affected by selection of b values the monoexponential model and to compare ADCs with (Ds) obtained from biexponential model.Twenty-four women (mean age 51.3 years) locally advanced cancer were included this study. Pre-treatment diffusion-weighted magnetic resonance imaging was performed using a 1.5-T system 0, 50, 100, 250 800 s/mm(2). Thirteen different value combinations used derive individual ADC maps....

Systemic failure remains a challenge in rectal cancer. We investigated the possible systemic anti-tumour immune activity invoked within oxaliplatin-based neoadjuvant therapy.In two high-risk patient cohorts, we assessed circulating levels of fms-like tyrosine kinase 3 ligand (Flt3L), factor reflecting both therapy-induced myelosuppression and activation tumour antigen-presenting dendritic cells, at baseline following induction chemotherapy sequential chemoradiotherapy, modalities containing...

Recognizing the link between altered tumor metabolism and disease aggressiveness, this study aimed to identify associations metabolic profiles therapeutic outcome in locally advanced rectal cancer (LARC).Pretreatment from 54 LARC patients receiving combined-modality neoadjuvant treatment surgery were acquired by high-resolution magic angle spinning magnetic resonance spectroscopy (HR MAS MRS). Metabolite concentrations correlated TNM presence of disseminated cells (DTC) at diagnosis, ypTN...

To investigate if MRI-assessed tumour volumetry correlates with histological response to neoadjuvant chemotherapy (NACT) and subsequent chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC).Data from 69 prospectively enrolled patients LARC receiving NACT followed by CRT radical surgery were analysed. Whole-tumour volumes contoured T2 weighted MR images obtained pre-treatment (VPRE), after (VNACT) the full course of (VCRT). VPRE, VNACT volume changes relative ΔVNACT ΔVCRT...

Histone deacetylase inhibitors (HDACis) like vorinostat are promising radiosensitisers in prostate cancer, but their effect under hypoxia is not known. We investigated gene expression associated with radiosensitisation of normoxic and hypoxic cancer cells by vorinostat.Cells were exposed to normoxia or subjected profiling before irradiation clonogenic survival analysis.Pretreatment led the intrinsically radioresistant DU 145 cells, radiosensitive PC-3 22Rv1 was independent status. Knockdown...

Background. Non-invasive visualization of tumor biological and molecular processes importance to diagnosis treatment response is likely be critical in individualized cancer therapy. Since conventional static 18F-FDG PET with calculation the semi-quantitative parameter standardized uptake value (SUV) may subject many sources variability, we here present an approach quantifying by analytic two-tissue compartment modeling, extracting kinetic parameters from dynamic PET. Further, evaluate...