A5003740867- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- Lymphoma Diagnosis and Treatment
- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Chronic Myeloid Leukemia Treatments
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Acute Lymphoblastic Leukemia research
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Medical Case Reports and Studies
- Infection Control in Healthcare
- Dermatological and COVID-19 studies
- RNA modifications and cancer
- Blood properties and coagulation
- Child Nutrition and Water Access
- Chronic Lymphocytic Leukemia Research
- Liver Disease Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Hepatitis B Virus Studies
- Surgical site infection prevention
- Hepatitis C virus research
Rashid Hospital
2025
Bayero University Kano
2024
University of Karachi
2022-2023
Center for Plant Conservation
2023
Karachi Medical and Dental College
2012-2023
Armed Forces Hospital
2023
Ministry of Health
2022
Hamad Medical Corporation
2020-2021
Assiut University Hospitals
2021
King Fahad Specialist Hospital
2020
Southeast Asian ovalocytosis (SAO) is a hereditary condition that widespread in parts of Asia. The ovalocytic erythrocytes are rigid and resistant to invasion by various malarial parasites. We have previously found the underlying defect SAO involves band 3 protein, major transmembrane which has abnormal structure function. now report two linked mutations erythrocyte gene SAO: (i) deletion codons 400-408 (ii) substitution, A----G, first base codon 56 leading substitution Lys-56 Glu-56. leads...
Epigenetic inheritance, the transmission of gene expression states from parent to daughter cells, often involves methylation DNA. In eukaryotes, cytosine is a frequent component epigenetic mechanisms. Failure transmit faithfully methylated or an unmethylated state can lead altered phenotypes in plants and animals. A central unresolved question epigenetics concerns mechanisms by which locus maintains, changes, its methylation. We developed “hairpin-bisulfite PCR” analyze these This method...
Southeast Asian ovalocytosis is a form of hereditary elliptocytosis in which the red cells are rigid and resistant to malaria invasion. The underlying molecular defect unknown.
This is a case of patient who presented with an urticarial rash 48 hours before developing symptoms fever and continuous cough. She subsequently developed angioedema her lips hands testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Urticarial rashes occurring other COVID-19 infection have been documented. demonstrates the importance heightened awareness that not all represent spontaneous urticaria as consequence, this may result in misdiagnosis...
Aim We aimed to determine the incidence of thrombotic complications and outcomes critically ill COVID-19 patients admitted intensive care unit (ICU) evaluate association between combined antithrombotic therapy mortality in ICU for pneumonia. Methods retrospectively collected data adult with a major hospital Dubai during pandemic. The primary outcome was in-hospital mortality. Secondary included complications, such as stay. study population classified into two groups based on type...
Background: Therapeutic hypothermia provides up to 30% neuroprotection in moderate severe hypoxic ischemic encephalopathy (HIE). Additional may be achieved by using concomitant pharmacologic neuroprotective agents. Aim: The aim was evaluate the safety of therapy therapeutic and magnesium sulfate (MgSO 4 ) management HIE term near-term infants. Study Design: Multicenter double-blind randomized controlled trial. Methodology: Term newborn infants (≥35 weeks) with a clinical diagnosis or were...
Introduction During the COVID-19 pandemic, researchers have used Internet-based applications to conduct virtual group meetings, but this is not feasible in low-resource settings. In a community health research project Bauchi State, Nigeria, restrictions precluded planned face-to-face meetings with groups. We tested feasibility of using cellular teleconferencing for these meetings. Methods an initial exercise, we six male and female focus discussions. Informed by experience, conducted...
Study design : Complete audit cycle. Introduction To highlight the unjustified overuse of perioperative antibiotics in clean non-instrumented lumbar spinal surgeries. convince orthopedic surgeons a methodological way local field comparison between common practice on use prophylaxis (PAP) surgeries and ideal according to “The guidelines published by North American Spine Society (NASS)”. Methods A complete cycle had been done. One hundred eight patients underwent tertiary spine center, during...
<b>Background and Aim:</b> The basic aim of this study was to find out the association genotypes with host age, gender viral load. <b>Material Methods:</b> present conducted at Social Security Hospital, Pakistan. This included 320 patients chronic hepatitis C virus (HCV) infection who were referred hospital between November 2011 July 2012. HCV detection genotyping performed seen <b>Results</b> : analysis revealed presence 1 3 further subtypes 1a, 1b, 3a, 3b mixed 1b + 3a 3b. Viral load...
This study aimed to determine the prevalence and associated characteristics of needle stick sharp injuries (NSSIs) among King Salman Armed Forces Hospital (KSAFH) personnel.Data was collected by reviewing all reported NSSIs KSAFH personnel between January 2020 December 2022.The 2.05%, with nurses being most commonly affected. Most occurred in patients' rooms/wards health care workers (HCWs) aged < 40 years. Of injured workers, 93.8% were immunized against hepatitis B virus (HBV).Educational...
A family is described in which three siblings had congenital abnormalities consistent with partial trisomy 9q syndrome. Karyotyping indicated that the mother was a carrier of two separate balanced reciprocal translocations involving chromosomes (46,XX,t (6;8;9)(6q27;8p23;9q32;9q13)) resulting from four breakpoints. The inherited der(8) their and hence were partially trisomic for 9q32→9qter monosomic 8p23→9pter (46,XX,der(8),t(8;9)(p23;q32)mat). clinical features cases comparable to those...
The spectrum of β-thalassemia mutations in Malaysia has been determined 45 chromosomes using dot blot hybridization the polymerase chain reaction amplified DNA and direct sequencing. Eleven different molecular defects, including those previously detected Chinese, Asian Indians, American blacks, a novel frameshift mutation causing β°-thalassemia were detected. Since this mutation, T deletion codon 15 creates new restriction site for EcoRllenzyme; could be by EcoRll digestion appropriate...
Clinical studies were carried out on mild Indian sickle cell anaemia in Malaysia, and genetic fertility 101 families with without sickle-cell haemoglobin (Hb S). The patients reached adulthood, pregnancies deliveries uneventful blood transfusion. There was no foetal wastage the number of children produced not significantly different from that Hb S. 28 hospitalized Plasmodium falciparum malaria infection also examined for their βS genotype. P. occurred much more frequently individuals S than carriers.
In nine Indian patients ranging in age between four and 61 years, with mild Hb SS disease very high F levels, the Gγ globin chain levels of their fetal hemoglobin ranged 64.0% 70.0%, a mean 68.1% (S.D. ± 2.6) total amount γ-globin chains. Eight were homozygous for specific βs gene haplotype #31. The other one was doubly heterozygous same another haplotype, which differed from #31 by presence Bam HI site 3' to β absence Pvu II 5' ψβ gene. organization studied Pst I restriction enzyme analysis...
The global rise of resistant bacteria threatens the effectiveness antibiotics, recommending that herbs' natural chemical constituents could provide alternative antimicrobial and insecticidal properties. study evaluated Citrus sinensis peel extracts' impact on bacterial species isolated from wound samples collected six hospitals. Quantitative Phytochemical analysis was conducted extracts, Isolates were tested biochemically molecularly for detection confirmation Staphylococcus aureus...
Abstract Restriction enzyme analysis of the α and ζ globin genes was carried out in four cases Hb Bart's hydrops fetalis, three patients with H disease without CoSp, 47 individuals thalassemia trait, normal individuals. All fetalis resulted from deletions α1 α2 which did not extend to ψζ1 ζ2 genes. The same type deletion observed thal 1 carriers, but two newborns (one Malay one Chinese extraction) had a nondeletion confirmed by quantitative αglobin gene analysis. In addition, other diagnosed...