A5000749349- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Regulation of Appetite and Obesity
- Neuroendocrine Tumor Research Advances
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Apelin-related biomedical research
- Diabetes and associated disorders
- Diet and metabolism studies
- Vanadium and Halogenation Chemistry
- Peptidase Inhibition and Analysis
- Adipose Tissue and Metabolism
- Hormonal Regulation and Hypertension
- Metabolism, Diabetes, and Cancer
- Thyroid Cancer Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Thyroid Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Chronic Kidney Disease and Diabetes
- Macrophage Migration Inhibitory Factor
- Signaling Pathways in Disease
- Ion Transport and Channel Regulation
- Vitamin C and Antioxidants Research
- Growth Hormone and Insulin-like Growth Factors
Hospital Universitario Puerta de Hierro Majadahonda
1987-2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2023
Universidad Autónoma de Madrid
1999-2018
We have studied the effect of Vasoactive Intestinal Peptide (VIP) on glycogenolysis and gluconeogenesis (as measured by conversion [U-14C]pyruvate into glucose) in hepatocytes isolated from fed rats. The influence VIP glycogen phosphorylase alpha pyruvate kinase activities, as well cAMP levels, was also evaluated. In addition, possible antagonism insulin these VIP-mediated effects investigated. enhanced both a dose-dependent manner. At 10(-6) M VIP, processes were increased 2-fold compared...
Monoclonal gammopathies (MGs) are a wide range of diseases that may evolve or progress over time. Comorbidity plays critical role in this setting. The co-occurrence two MGs is not rare event. evidence on the association systemic light chain (AL) amyloidosis and multiple myeloma (MM) scarce controversial. Herein we aim to address topic large series patients referral center. All consecutive AL treated at our center from January 2005 April 2023 were prospectively enrolled clinical...
Amylin, a peptide hormone from pancreatic β-cells, is reported to inhibit insulin secretion in vitro and vivo nutrient-stimulated glucagon vivo. However, it has been not affect arginine-stimulated vitro. To resolve if the latter resulted inactive (a problem early literature), those experiments were repeated here with well-characterized found be valid. In isolated perfused rat pancreas preparations, coperfusion 1 nM amylin had no effect on arginine-, carbachol-, or vasoactive intestinal...
Kisspeptins are a family of peptides encoded by the KISS1 gene, which binds to G-protein-coupled receptor (GPR54), an orphan GPR54 related galanin receptors. Endogenous forms composed 54, 14, and 13 amino acids have been identified. Kisspeptin mRNAs detected in pancreatic B A cells. Furthermore, kisspeptin-54 has shown slightly stimulate last phase glucose-induced insulin secretion mouse human islets inhibit release MIN6 We investigated effect kisspeptin-13 on insulin, glucagon, somatostatin...
Urotensin-II (U-II) is a vasoactive cyclic dodecapeptide first isolated from the caudal neurosecretory system teleost [1], which has been recently cloned number of species including mouse, rat [2] and human [3].
Galanin is a novel peptide, widely distributed throughout the central and peripheral nervous system, including nerve endings surrounding pancreatic islets. In dogs, galanin infusion has been reported to induce hyperglycemia along with reduction of circulating insulin. this work, we have studied effect (a 200 ng bolus followed by constant at concentration 16.8 ng/ml for 22-24 min) on insulin, glucagon, somatostatin secretion in perfused rat pancreas! addition, investigated (10 100 nM)...
The SERPINA1 gene is highly polymorphic, with more than 100 variants described in databases. encodes the alpha-1 antitrypsin (AAT) protein, and severe deficiency of AAT a major contributor to pulmonary emphysema liver diseases. In Spanish patients deficiency, we identified seven new involving amino acid substitutions different exons: PiSDonosti (S+Ser14Phe), PiTijarafe (Ile50Asn), PiSevilla (Ala58Asp), PiCadiz (Glu151Lys), PiTarragona (Phe227Cys), PiPuerto Real (Thr249Ala), PiValencia...
Positive impact on serum lipids and cytokines after functional beverage's intake by postmenopausal women.
Results of studies on the effects exogenous galanin islet cell secretion are controversial. Until recently, only pig has been available, and structural dissimilarities among molecules different species might have contributed to discrepancies study results. Thus, we investigated influence synthetic rat (50 nM) unstimulated insulin, glucagon, somatostatin release responses these hormones arginine (10 mM), glucose (16.6 vasoactive intestinal polypeptide (VIP; 1 in a homologous animal model,...