A5049126629- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacology and Obesity Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Children's Physical and Motor Development
- Diet and metabolism studies
- Lipoproteins and Cardiovascular Health
- Reproductive Biology and Fertility
- Blood Pressure and Hypertension Studies
- Diabetes Management and Research
- Peroxisome Proliferator-Activated Receptors
- Hormonal Regulation and Hypertension
- Child Development and Digital Technology
- Atrial Fibrillation Management and Outcomes
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cardiovascular Disease and Adiposity
- Protease and Inhibitor Mechanisms
- Diabetes and associated disorders
- Sports Science and Education
- Blood Coagulation and Thrombosis Mechanisms
- Cellular Mechanics and Interactions
- Sports and Physical Education Research
- Genomic variations and chromosomal abnormalities
- Congenital heart defects research
Zurich University of Teacher Education
2023-2024
Humanitas University
2023
IRCCS Istituto Auxologico Italiano
2015-2022
University of Pavia
2005-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2006-2021
University of Colorado Denver
2021
Children's Hospital Colorado
2021
University of Colorado Anschutz Medical Campus
2021
University of Milan
2011-2018
Neuroscience Institute
2012-2016
There are conflicting data in the literature regarding expression pattern of vascular matrix metalloproteinase (MMP) system and their inhibitors (TIMPs) human hypertension. The authors hypothesized that MMP-2, MMP-9, TIMP-1 would be abnormal hypertension, reflecting alterations extracellular (ECM) turnover. measured plasma levels activities 44 hypertensive patients controls. MMP-2 activity were significantly higher group (p < .0001). Significant increase was also observed for MMP-9 level...
Incretin-based therapies have provided additional options for the treatment of type 2 diabetes mellitus. The aim our study was to evaluate effects exenatide compared glibenclamide on body weight, glycemic control, beta-cell function, insulin resistance, and inflammatory state in patients with diabetes.One hundred twenty-eight uncontrolled mellitus receiving therapy metformin were randomized take 5 microg twice a day or 2.5 mg three times titrated 10 day. We evaluated mass index (BMI),...
<h3>Importance</h3> There is high usage of antibiotics in the emergency department (ED) for children with acute respiratory illnesses. Studies have reported decreased antibiotic use among inpatients rapid pathogen (RRP) testing. <h3>Objective</h3> To determine whether RRP testing leads to and health care influenzalike illness (ILI) an ED. <h3>Design, Setting, Participants</h3> A randomized clinical trial aged 1 month 18 years presenting ED ILI from December 1, 2018, November 30, 2019, was...
Background and objective: Metformin is considered the gold standard for type 2 diabetes treatment as monotherapy in combination with sulphonylureas insulin. The of metformin thiazolidinediones less well studied. aim present study was to assess differential effect, tolerability, combined pioglitazone or rosiglitazone on glucose, coagulation fibrinolysis parameters patients mellitus metabolic syndrome. Methods: This 12-month, multicentre, double-blind, randomized, controlled, parallel-group...
Home care support is beneficial for children needing mechanical ventilation, when clinically stable.A retrospective analysis was carried out of the long-term home ventilation management a pediatric population with chronic respiratory failure composed 20 ventilator-dependent categorized according to age, diagnosis and support. Age groups consisted 10% under 1 year, 30% between 2 5 years, 6 12 older than years. Diagnostic categories included myopathic disorder, n = 5; congenital central...
Angiotensin II receptor blockers represent a class of effective and well-tolerated orally active antihypertensive drugs in the general hypertensive population diabetic patients. The aim our study was to investigate metabolic effects telmisartan irbesartan subjects treated with rosiglitazone.We evaluated 188 type 2 patients syndrome. All took fixed dose 4 mg rosiglitazone/day. We administered 40 telmisartan/day or 150 irbesartan/day their body mass index, glycosylated haemoglobin (HbA(1c)),...
Can high resolution array-CGH analysis on a cohort of women showing primary ovarian insufficiency (POI) phenotype in young age identify copy number variants (CNVs) with deleterious effect function?This approach has proved effective to clarify the role CNVs POI pathogenesis and better unveil both novel candidate genes pathogenic mechanisms.POI describes progression toward cessation function before 40 years. Genetic causes are highly heterogeneous despite several being associated failure, most...
Our study wants to evaluate the effects of one year treatment with orlistat plus L-carnitine compared alone on body weight, glycemic and lipid control, insulin resistance state in type 2 diabetic patients. Two hundred fifty-eight patients uncontrolled diabetes mellitus (T2DM) [glycated hemoglobin (HbA(1c)) > 8.0%] therapy different oral hypoglycemic agents or were enrolled this randomised take 120 mg three times a day g time day. We evaluated at baseline, after 3, 6, 9, 12 months these...
The aim of the study was to compare effects vildagliptin added pioglitazone or glimepiride on metabolic and insulin resistance related-indices in poorly controlled type 2 diabetic patients (T2DM). 168 with T2DM were randomized take either 30 mg once a day plus 50 twice 3 times day. We evaluated body weight, mass index (BMI), glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), postprandial (PPG), (FPI), homeostasis model assessment (HOMA-IR), beta-cell function (HOMA-beta), proinsulin...
Objective: To compare the metabolic effects of acarbose and repaglinide in type 2 diabetic patients who are being treated with a sulphonylurea–metformin combination therapy. The primary endpoint study was to evaluate which add-on treatment between is more efficacious reducing PPG. second these two global management glucose homeostasis enrolled patients.Research design methods: After 4-week run-in period suplonylurea–metformin combination, 103 were randomised receive addition either...
The aim of this study was to evaluate the effect an oral glucose tolerance test (OGTT) on level endothelial dysfunction and vascular inflammation markers in healthy subjects (H) diabetic overweight patients (D). We enrolled 256 274 type 2 patients. evaluated blood (BG), soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), high-sensitivity C reactive protein (hsCRP), cell (sVCAM-1), E-selectin (sE-selectin), tumor necrosis factor-α (TNF-α) at baseline after OGTT....
To evaluate the distribution of matrix metalloproteinase-2 (MMP-2), metalloproteinase-9 (MMP-9), and their specific inhibitors in a sample patients affected by mild dyslipidemia but not yet treated with antihyperlipidemic drugs.One hundred sixty-eight Caucasian aged >or=18 yr either sex combined who had never previously taken lipid-lowering medications were evaluated. As control population, we enrolled 179 healthy subjects, sex. We evaluated body mass index (BMI), fasting plasma glucose...
Bone morphogenetic protein 15 (BMP15) encodes an oocyte factor with a relevant role for folliculogenesis as homodimer or cumulin heterodimer (BMP15-GDF9). Heterozygous BMP15 variants in the precursor mature peptide had been associated primary ovarian insufficiency (POI), but underlying mechanism remains elusive and double dose of was suggested to be required adequate reserve. We uncovered two homozygous null found girls POI amenorrhea. Both heterozygous mothers reported physiological...
Aim: Accumulating evidence suggests that combination therapy using oral antidiabetic agents with different mechanisms of action may be highly effective in achieving and maintaining target blood glucose levels. The aim our study is to evaluate the differential effect on lipid parameters association between glimepiride plus metformin rosiglitazone patients affected by type 2 diabetes metabolic syndrome. Methods: Patients were enroled, evaluated followed at two Italian centres. We 99 diabetic...