Type 2 diabetes mellitus (DM2) is one of the most widely prevalent diseases worldwide and currently screened by invasive techniques based on enzymatic assays that measure plasma glucose concentration in a laboratory setting. A promising plan action for screening DM2 to identify molecular signatures non-invasive fashion. This work describes application portable Raman spectroscopy coupled with several supervised machine-learning techniques, discern between diabetic patients healthy controls...

The augmented consumption of dietary advanced glycation end products (dAGEs) has been associated with increased oxidative stress and inflammation, however, there is insufficient information over the effect on insulin resistance. objective present study to investigate dAGEs restriction tumor necrosis factor-α (TNF-α), malondialdehyde, C-reactive protein (CRP), resistance in DM2 patients. We carried out a randomized 6 weeks prospective two groups patients: subjects standard diet (n = 13), vs...

Dietary advanced glycation end products (dAGEs) could be involved on diabetes complications, yet their quantification is not standardized. The objective of this study was to design a food frequency questionnaire (FFQ) for dAGEs, and assess its reliability validity. For the design, data from 30 subjects used. final instrument had 90 items. To measure validity, 20 participants with type 2 filled out twice FFQ (FFQ-T1, FFQ-T2) 7-day records (7-dFR). Shrout–Fleiss coefficient 0.98 showing good...

Introduction: advanced glycation end-products (AGEs) interact with the receptor for AGEs (RAGE). Full-length RAGE is associated intracellular signal transduction, and soluble-RAGE (sRAGE) lacks transmembrane cytoplasmic domains, acting as a competitive inhibitor of AGEs-RAGE binding. sRAGE levels in healthy children are cell surface expression RAGE. However, has not been explored childhood obesity. Objective: study aim was to evaluate gene its association cardiometabolic markers. Methods:...

Objective: The aim of this study was to evaluate soluble receptor for advanced glycation end products (sRAGE) and (AGEs) in adolescents with without obesity (OB) their correlation vascular damage. Methods: This is a cross-sectional 15–19 years old adolescents: 33 OB normal weight (NW), each group included 17 male 16 female. Lipid profile, insulin, carboxymethylysine (CML), sRAGE, total AGEs, dietary AGEs intake (dAGEs) were evaluated. Vascular damage measured by flow-mediated vasodilation...

Dietary advanced glycation end products (AGEs) can be formed via the Maillard reaction and several alternative pathways. AGEs exert their deleterious effects by damaging protein structure function, as well through activation of cellular mechanisms. At level, have been attributed to AGE-binding proteins. Increased levels implicated in chronic diseases, including diabetes-related complications such renal retinopathy, neuropathy, cardiovascular delayed wound healing. To investigate role...

Background and objectives: To identify the relationship between neck circumference (NC) cardiometabolic risk factors in children. Materials Methods: Children adolescents 6–18 years old (n = 548) from five counties of San Luis Potosí, México were included. Data was collected for biological markers (glucose lipid profile) anthropometric clinical measurements—weight, height, NC, waist (WC), blood pressure (BP). Body mass index (BMI) calculated using Quetelet formula (kg/m2). Descriptive...

In this article, we investigated the feasibility of using Raman spectroscopy and multivariate analysis method to noninvasively screen for prediabetes diabetes in vivo. measurements were performed on skin from 56 patients with diabetes, 19 prediabetic 32 healthy volunteers. These spectra collected along reference values provided by standard glycated hemoglobin (HbA1c) assay. A multiclass principal component support vector machine (PCA-SVM) model was created labeled validated through a...

This study evaluated the acute effect of black bean protein hydrolysate (BPH) on postprandial glucose and insulin levels in adults with normal tolerance (NGT) or prediabetes. First, an silico predictive digestion was performed twenty peptides identified BPH. Then, 28 NGT prediabetes were randomized to a parallel double-blind, placebo-controlled trial. Following consent, participants randomly assigned one two groups, placebo, 5 g To evaluate effects BPH, oral test administered, blood samples...

Background: Consumption of dietary advanced glycation end products is linked to metabolic syndrome. The objective was describe the association between intake and syndrome in young Mexican adults. Methods: present a cross-sectional study 126 adults 18⁻35 years old evaluating through harmonized criteria. Macronutrients were estimated three 24-hour recalls food composition tables. Association high (≥10,000 kU/day) evaluated logistic regression models adjusted by sex, age, family history...

Snack alternatives based on common beans (Phaseolus vulgaris L.) have been developed to promote pulse consumption. The purpose of this study was evaluate the chemical composition, sensory acceptance and effect bean baked snack (CBBS) consumption blood lipid levels in participants with overweight altered levels. A evaluation by 80 untrained judges carried out using a hedonic scale. randomized crossover 2 × trial performed, where 20 one alteration consumed 32 g CBBS or did not consume it...

RAGE is a multi-ligand transmembrane glycoprotein that promotes biological signals associated with inflammatory responses and degenerative diseases. sRAGE soluble variant, proposed as an inhibitor of activity. -374 T/A -429 T/C polymorphisms the advanced glycation end products receptor AGER gene are development some diseases, such type cancer, cardiovascular disease, micro macrovascular disease in diabetes among others but their role metabolic syndrome (MS) still unknown. We studied 80...

Diet is an important source of exogenous advanced glycation end products (AGEs). Dietary AGEs content depends on nutrient composition and the way food processed/cooked. The objective our study was to compare intake two different ethnic groups (Mexicans non-Hispanic whites) with type 2 diabetes mellitus (DM) relationship between dietary diabetes-related complications. Complications were self-reported by subjects (n = 65) categorized according a published DM disease severity index as low risk...

Childhood obesity is associated with insulin resistance (IR), increased levels of small dense low-density lipoprotein (sd-LDL) as well augmented hepatic de novo lipogenesis, which implies triose phosphate fluxes that may lead to methylglyoxal (MG) and its catabolic end product D-lactate. We hypothesized obese adolescents have D-lactate serum high incidence sd-LDL.This a cross-sectional study where the anthropometric characteristics, atherogenic dyslipidemia complex, sd-LDL (Lipoprint,...

Over consumption of added sugar is associated with obesity, non-alcoholic fatty liver disease (NAFLD), and insulin resistance (IR).The objective the study was to insulin-like growth factor binding protein-1 (IGFBP-1) NAFLD their relationship fructose in children obesity.A cross-sectional carried out 6-11 years old obesity. Anthropometric measurements, consumption, glucose, lipid profile, insulin, IGFBP-1 levels were evaluated; homeostatic model assessment IR (HOMA-IR) used. evaluated by...

We show the spectra of advanced glycation products in response to recent comments made by Bratchenko et al.Our results suggest that information retrieved Raman spectroscopy is relevant screening diabetic patients, however, comparison carried out our paper, between ANN and SVM, was not fair, because erroneous PCA selection procedure different sources variation present analysis.

Introducción: El objetivo de esta investigación fue evaluar el efecto una intervención educativa contextualizada a los alimentos disponibles en comunidad indígena la Huasteca Potosina, sobre hemoglobina capilar.Material y métodos: Se llevó cabo un estudio cuasiexperimental pretest-postest solo grupo, diciembre 2014 2015 niños indígenas 0 5 años, Tocoy, San Antonio, Luis Potosí, México. realizó 6 meses constó talleres educación nutricional cuales incluían pláticas informativas, cocina...