A5073929371- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Pluripotent Stem Cells Research
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Pancreatic function and diabetes
- Analytical Chemistry and Sensors
- Advanced Nanomaterials in Catalysis
- Electrochemical sensors and biosensors
- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Electrochemical Analysis and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Tissue Engineering and Regenerative Medicine
- Advanced Sensor and Energy Harvesting Materials
- Nerve injury and regeneration
- Hydrogels: synthesis, properties, applications
- Nanopore and Nanochannel Transport Studies
- Hemoglobin structure and function
- Extracellular vesicles in disease
- Nanoparticles: synthesis and applications
- Liver physiology and pathology
- Mesenchymal stem cell research
- Carbon dioxide utilization in catalysis
Mayo Clinic in Florida
2021-2024
Kwangwoon University
2011-2024
Kyungpook National University
2024
Mayo Clinic
2022-2024
WinnMed
2021
Gwangju Institute of Science and Technology
2012-2018
Government of the Republic of Korea
2016
Gwangju University
2016
In-Q-Tel
2014
Metal–organic frameworks (MOFs) can be applied in biology and medicine as drug delivery systems by carrying drugs on their surfaces or releasing bioactive ligands. To investigate the therapeutic potential of hydrogels that contain MOFs, three MOFs containing glutarate 1,2-bis(4-pyridyl)ethylene ligands were synthesized previously reported hydrothermal solvothermal reactions: Cu-MOF 1, Co-MOF 2, Zn-MOF 3. Bioactive MOF-embedded (hydrogel@Cu-MOF hydrogel@Co-MOF hydrogel@Zn-MOF 3) prepared UV...
Polysiloxanes (PSs) have been widely utilized in the industry as lubricants, varnishes, paints, release agents, adhesives, and insulators. In addition, their applications expanded to include development of new biomedical materials. To modify PS for application therapeutic purposes, a flexible antibacterial Cu-MOF (metal-organic framework) consisting glutarate 1,2-bis(4-pyridyl)ethane ligands was embedded via hydrosilylation reaction vinyl-terminated H-terminated PSs at 25 °C. The...
An in situ heparin-based forming hydrogel that cures under visible-light is formulated using eosin Y as a photoinitiator with triethanolamine an electron donor to initiate reaction of thiolated-heparin acrylate-ended poly(ethylene glycol). Formulations and irradiation conditions are presented for control heparin content (1.6 3.3% w/v), modulus (100–10 000 Pa), gelation time (30–600 s). Encapsulation 3T3 fibroblasts the gave over 96% viability all examined. In vitro characterization epidermal...
Abstract Cellular therapies based on human pluripotent stem cells (hPSCs) offer considerable promise for treating numerous diseases including diabetes and end stage liver failure. Stem cell spheroids may be cultured in stirred bioreactors to scale up production numbers relevant use humans. Despite significant progress bioreactor culture of cells, areas improvement remain. In this study, we demonstrate that microfluidic encapsulation hPSCs formation spheroids. A co-axial droplet device was...
Mechanical stimulus is one of the universally accessible physical ways triggering drug release from their carriers. Hollow microcapsules made polyelectrolyte multilayers by conventional methods are not elastic enough to respond a large and repetitive mechanical deformation. Here, hybrid hollow capsules comprising alternating layers inorganic colloidal particles biopolymers were prepared layer-by-layer approach followed freezing-assisted crosslinking polymer layers. The size capsule was...
The ability to maintain functional hepatocytes has important implications for bioartificial liver development, cell-based therapies, drug screening, and tissue engineering. Several approaches can be used restore hepatocyte function in vitro, including coating a culture substrate with extracellular matrix (ECM), encapsulating cells within biomimetic gels (Collagen- or Matrigel-based), co-cultivation other cells. This paper describes the use of bioactive heparin-based core-shell microcapsules...
Polyurethane foams (PUFs) have attracted attention as biomaterials because of their low adhesion to the wound area and suitability biodegradable or bioactive materials. The composition building blocks for PUFs can be controlled with additives, which provide excellent anti-drug resistance biocompatibility. Herein, nanosized Cu-BTC (copper(II)-benzene-1,3,5-tricarboxylate) was incorporated into a PUF via crosslinking reaction castor oil chitosan toluene-2,4-diisocyanate, enhance therapeutic...
Human pluripotent stem cells (hPSCs) are capable of unlimited proliferation and can undergo differentiation to give rise tissues the three primary germ layers. While directing lineage selection hPSCs has been an active area research, improving efficiency remains important objective. In this study, we describe a two-compartment microfluidic device for co-cultivation adult human hepatocytes cells. Both cell types were cultured in 3D or spheroid format. Adult remained highly functional over...
Contamination of heparin with oversulfated chondroitin sulfate (OSCS) became a matter grave concern in the medical field after many fatal responses to OSCS tainted products occurred during 2007-2008 period. Even though standard lab-based analytical techniques such as nuclear magnetic resonance (NMR) and strong anion-exchange high performance liquid chromatography (SAX-HPLC) have proven useful for monitoring content products, an easy-to-use, quick, portable, cost-efficient method is still...
The biodegradable and nitric oxide (NO)-releasing hyaluronic acid (HA)-based nanofibers developed in this study have the potential application wound healing.
Nitric oxide (NO) has been shown to promote revascularization and nerve regeneration after peripheral injury. However, in vivo application of NO remains challenging due the lack stable carrier materials capable storing large amounts molecules releasing them on a clinically meaningful time scale. Recently, silica nanoparticle system reversible storage release at controlled sustained rate was introduced. In this study, NO-releasing nanoparticles (NO-SNs) were delivered nerves rats acute crush...
Compared to most of nano-sized particles, core-shell-structured nanoflowers have received great attention as bioactive materials because their high surface area with the flower-like structures. In this study, Si-based NiO nanoflowers, Si@NiO, were prepared by a modified chemical bath deposition method followed thermal reduction. The crystal morphology and basic structure composites characterized powder X-ray diffraction (PXRD), Fourier-transform infrared spectroscopy (FT-IR), scanning...
Journal Article A biocompatible method of controlled retrieval cell-encapsulating microgels from a culture plate Get access Kihak Gwon, Gwon School Materials Science and Engineering, Gwangju Institute Technology (GIST), 261 Cheomdan-gwagiro, Buk-gu, 500-712, Republic Korea. Fax: +82-62-715-2304; Tel: +82-62-715-2305 Search for other works by this author on: Oxford Academic Google Scholar Mihye Kim, Kim Giyoong Tae E-mail: gytae@gist.ac.kr Integrative Biology, Volume 6, Issue June 2014, Pages...
Human pluripotent stem cells (hPSC) hold considerable promise as a source of adult for treatment diseases ranging from diabetes to liver failure. Some the challenges that limit clinical/translational impact hPSCs are high cost and difficulty in scaling-up existing differentiation protocols. In this paper, we sought address these through development bioactive microcapsules. A co-axial flow focusing microfluidic device was used encapsulate microcapsules comprised an aqueous core hydrogel...