A5100339309- Evolution and Genetic Dynamics
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Virus-based gene therapy research
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- Enzyme Structure and Function
- RNA modifications and cancer
- Enzyme Production and Characterization
- Cancer Research and Treatments
- Enzyme Catalysis and Immobilization
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Photochemistry and Electron Transfer Studies
- Protein Tyrosine Phosphatases
- Primate Behavior and Ecology
- Surfactants and Colloidal Systems
- Robotic Path Planning Algorithms
- Evolution and Paleontology Studies
- Vehicle Routing Optimization Methods
- Transportation and Mobility Innovations
- Immune cells in cancer
- Protein Interaction Studies and Fluorescence Analysis
- Genetic Mapping and Diversity in Plants and Animals
- RNA Research and Splicing
Brigham and Women's Hospital
2022-2023
Harvard University
2022-2023
Huazhong University of Science and Technology
2023
Tongji Hospital
2023
Chinese Academy of Sciences
2008-2022
Beijing Institute of Genomics
2019-2022
Shanghai Center For Bioinformation Technology
2021-2022
Institute of Geology and Geophysics
2022
Institute of Zoology
2015
University of Chinese Academy of Sciences
2015
Abstract Glycerophosphodiester phosphodiesterase (GDPD; EC 3.1.4.46) catalyzes the hydrolysis of a glycerophosphodiester to an alcohol and glycerol 3‐phosphate in metabolism. It has important role synthesis variety products that participate many biochemical pathways. We report crystal structure Thermoanaerobacter tengcongensis GDPD (ttGDPD) at 1.91 Å resolution, with calcium ion as substrate mimic coordinated this (PDB entry 2pz0). The ttGDPD dimer intermolecular disulfide bridge two...
Abstract The mechanism of interaction between bovine serum albumin (BSA) and 2‐naphthylamine (2‐NA) in aqueous solution was investigated by fluorescence spectroscopy, circular dichroism (CD) spectra, UV–vis spectroscopy. It proved from spectra that the quenching BSA 2‐NA a result formation complex BSA, binding constants ( K ) as well numbers sites for were determined according to modified Stern–Volmer equation. results synchronous CD demonstrated could decrease amount α‐helix leading...
Inferring the demographic history of a population is essential in genetic studies. Though inference methods based on sequentially Markov coalescent can present detail, these assume that size remains unchanged each time interval during discretizing hidden state model. Therefore, fail to uncover detailed interval.We new method called Beta-PSMC, which introduces probability density function beta distribution with broad variety shapes into Pairwise Sequentially Markovian Coalescent (PSMC) model...
The mevalonate pathway of isoprenoid biosynthesis is the most chemically diverse in nature. This produces isopentenyl diphosphate,1 fundamental five-carbon building block for over 23,000 compounds,2 such as sterols,3 caroteniods,4 dolichols,5 ubiquinone,6 and some prominent classes prenylated proteins.7 These compounds are essential cell growth differentiation, gene expression, protein glycosylation, cytoskeletal assembly. In addition, posttranslational modification proteins involved...
RNA 5-methylcytosine (m5C) is a type of post-transcriptional modification that may be involved in numerous biological processes and tumorigenesis. m5C can profiled at single-nucleotide resolution by high-throughput sequencing treated with bisulfite (RNA-BisSeq). However, the exploration transcriptome-wide profile potential function splicing remains to elucidated due lack isoform level quantification tool.We developed computational package quantify Epitranscriptomal transcript (named Episo)....
Summary Due to the polymorphism in ancestral species and stochastic fluctuation of coalescent process, divergence time between sequences from two closely related varies throughout genome. This variation is described by an exponential distribution. Gene flow causes additional sequence time, beyond expected process. prediction can be used test for gene using genomic data. A previous implementation model empirical beta distribution describe across genome, with numerical integration calculate 3D...
5-Methylcytosine (m5C) is a type of chemical modification on the nucleotides and widespread in both DNA RNA. Although m5C has been extensively studied over past years, distribution biological function RNA still remain to be elucidated. Here, I explored profiles four mouse tissues by applying cytosine methylation data analysis tool public data. found that rates were same with averages level at single-nucleotide level. Furthermore, gave mathematical formula describe observed relationship...
Abstract Background: Patients with malignant brain tumor, glioblastoma (GBM), do not benefit from promising immunotherapies that use checkpoint inhibitors, such as PD-1 and CTLA-4 blockade antibodies. Several reasons may underlie this clinical result, particularly because of immunogenically cold nature the GBM microenvironment, which is characterized by low level infiltrating cytotoxic CD8+ T cells an enriched myeloid suppressor cell population. We other groups hypothesize oncolytic virus...