A5011995444- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Diabetes Management and Research
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Cholinesterase and Neurodegenerative Diseases
- Anesthesia and Sedative Agents
- Neurological Disorders and Treatments
- Chronic Disease Management Strategies
University of Antwerp
2021-2025
ETH Zurich
2024
University Medical Center Groningen
2023
University of Groningen
2023
Early-onset neurodegeneration leads to cognitive and behavioral symptoms in frontotemporal dementia (FTD) motor disturbances amyotrophic lateral sclerosis (ALS). Despite distinct clinical profiles, more than half of FTD patients experience ALS-related vice versa. Spinal cord monoamine neurotransmitter alterations were reported ALS, but not yet FTD. Therefore, we compared monoaminergic turnover across the FTD-ALS continuum. Reversed-phase, ultra-high-performance liquid chromatography with...
Objectives: Despite distinct clinical profiles, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients share a remarkable portion of pathological features, with substantial percentage displaying mixed disease phenotype. Kynurenine metabolism seems to play role in dementia-associated neuroinflammation has been linked both diseases. We aimed explore dissimilarities kynurenine pathway metabolites these early onset neurodegenerative disorders brain-region-specific manner....
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains major challenge. Here, we combine RNA sequencing with selective pharmacological, chemogenetic, and optogenetic manipulations isolate contribution locus coeruleus-noradrenaline (LC-NA) system stress response mice. We reveal that NA release during exposure regulates large reproducible set genes dorsal ventral...
Abstract Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains major challenge. Here we combine RNA-sequencing with selective pharmacological, chemogenetic and optogenetic manipulations isolate contribution locus coeruleus - noradrenaline (LC-NA) system stress response. We reveal that NA-release during exposure regulates large reproducible set genes dorsal ventral...
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains major challenge. Here, we combine RNA sequencing with selective pharmacological, chemogenetic, and optogenetic manipulations isolate contribution locus coeruleus-noradrenaline (LC-NA) system stress response mice. We reveal that NA release during exposure regulates large reproducible set genes dorsal ventral...
Abstract Objectives Delirium frequently arises in older demented and non‐demented patients postoperative, clinical settings. To date, the underlying pathophysiological mechanisms remain poorly understood. Monoamine neurotransmitter alterations have been linked to delirium cognitive impairment. Our aim was investigate if this holds true cognitively normal impaired experiencing following hip surgery. Methods Monoamines metabolites were measured plasma samples of 181 individuals by means...
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains major challenge. Here we combine RNA-sequencing with selective pharmacological, chemogenetic and optogenetic manipulations isolate contribution locus coeruleus - noradrenaline (LC-NA) system stress response. We reveal that NA-release during exposure regulates large reproducible set genes dorsal ventral...
Abstract Background Down syndrome (DS, trisomy 21) is the most frequent genetic cause of intellectual disability (ID), prevalent in approximately 1 900 live births (Loane et al., 2013). People with DS are at high risk to develop Alzheimer’s disease dementia (AD) (Lott & Head, 2001). Onset clinical symptoms varies substantially time. Consequently, predicting and monitoring decline onset a diagnostic challenge, while it essence daily care support. Behavioral Psychological Symptoms Dementia...
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains major challenge. Here we combine RNA-sequencing with selective pharmacological, chemogenetic and optogenetic manipulations isolate contribution locus coeruleus - noradrenaline (LN-NA) system stress response. We reveal that NA-release during exposure regulates large reproducible set genes dorsal ventral...
Abstract Background Despite disease‐specific symptoms, differentiation between Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) remains challenging, especially in early, prodromal stages. This is fueled by overlapping pathology both diseases (Slaets et al., 2013). Monoamine neurotransmitters are significantly altered DLB AD capable of distinguishing from AD, when added to the panel cerebrospinal fluid (CSF) biomarkers (Aβ 1‐40 , Aβ 1‐42 T‐tau, P‐tau) as standalone (Janssens...
Abstract Background People with DS are at high risk to develop Alzheimer’s disease dementia (AD) (Lott & Head, 2001). Predicting and monitoring decline onset of is a diagnostic challenge essence in daily care support for people DS. Behavioral Psychological Symptoms Dementia (BPSD) an easily accessible tool the prediction population. The BPSD‐DS II scale was developed validated by our team identify behavioral changes linked AD between last six months pre‐existing behavior individual...