A5062587286- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Optical Imaging and Spectroscopy Techniques
- Cardiac electrophysiology and arrhythmias
- Attention Deficit Hyperactivity Disorder
- Cellular transport and secretion
- Child and Adolescent Psychosocial and Emotional Development
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Genetic Neurodegenerative Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Marine animal studies overview
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Plant and animal studies
- Neuroscience and Neural Engineering
University of Zurich
2016-2024
ETH Zurich
2018-2024
University of California, Irvine
2024
Neurosciences Institute
2023-2024
Department of Medical Sciences
2023-2024
Neuroscience Institute
2023-2024
Institute of Pharmacology
2017
Freie Universität Berlin
2013
BackgroundAcutely stressful experiences can trigger neuropsychiatric disorders and impair cognitive processes by altering hippocampal function. Although the intrinsic organization of hippocampus is highly conserved throughout its long dorsal-ventral axis, dorsal (anterior) mediates spatial navigation memory formation, whereas ventral (posterior) involved in emotion regulation. To understand molecular consequences stress, detailed genome-wide screens are necessary need to distinguish between...
Abstract The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief swim exposure trigger an in mice, which transiently increases anxiety, without leading lasting maladaptive changes. Using multiomic profiling, such as proteomics, phospho-proteomics, bulk mRNA-, single-nuclei small RNA-, TRAP-sequencing, characterize stress-induced events mouse hippocampus over time. Our...
Honeybees, like other insects, accumulate electric charge in flight, and when their body parts are moved or rubbed together. We report that bees emit constant modulated fields flying, landing, walking during the waggle dance. The emitted by dancing consist of low- high-frequency components. Both components induce passive antennal movements stationary according to Coulomb's law. Bees learn both field context appetitive proboscis extension response conditioning. Using this paradigm, we...
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains major challenge. Here, we combine RNA sequencing with selective pharmacological, chemogenetic, and optogenetic manipulations isolate contribution locus coeruleus-noradrenaline (LC-NA) system stress response mice. We reveal that NA release during exposure regulates large reproducible set genes dorsal ventral...
Abstract Alterations of neuronal activity due to changes in GABA A receptors ( R ) mediating tonic inhibition influence different hippocampal functions. Gabra5 ‐null mice and α5 subunit (H105R) knock‐in exhibit signs dysfunction, but are capable improved performance several learning memory tasks. Accordingly, alleviating abnormal ergic the formation by selective α5‐ modulators represents a possible therapeutic approach for intellectual deficit disorders. Adult neurogenesis dentate gyrus is...
In developing brain neuronal migration, dendrite outgrowth and dendritic spine are controlled by Cdc42, a small GTPase of the Rho family, its activators. Cdc42 function in promoting actin polymerization is crucial for glutamatergic synapse regulation. Here, we focus on GABAergic synapse-specific activator collybistin (CB) examine functional differences between splice isoforms CB1 CB2. We report that CB2 differentially regulate formation vitro along proximal-distal axis adult-born neuron...
Abstract Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains major challenge. Here we combine RNA-sequencing with selective pharmacological, chemogenetic and optogenetic manipulations isolate contribution locus coeruleus - noradrenaline (LC-NA) system stress response. We reveal that NA-release during exposure regulates large reproducible set genes dorsal ventral...
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains major challenge. Here, we combine RNA sequencing with selective pharmacological, chemogenetic, and optogenetic manipulations isolate contribution locus coeruleus-noradrenaline (LC-NA) system stress response mice. We reveal that NA release during exposure regulates large reproducible set genes dorsal ventral...
Abstract Early-life adversity increases risk for mental illnesses including depression and substance use disorders, disorders characterized by dysregulated reward behaviors. However, the mechanisms which transient ELA enduringly impacts circuitries are not well understood. In mice, leads to anhedonia-like behaviors in males augmented motivation palatable food sex-reward cues females. Here, of genetic tagging demonstrated robust, preferential, sex-specific activation paraventricular nucleus...
Since prehistoric times, cetaceans have been important food sources, but they also seen as monsters of the sea, a perception that did not change much during past centuries. Due to better understanding their biology in recent years, public towards has evolving. Various studies developed aiming evaluate attitude and humans cetaceans, these local focused on specific target groups. Our study aimed wide scale by using an international online questionnaire distributed exclusively social media. An...
Abstract The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain, regulates many fundamental brain functions, and is implicated in several neuropsychiatric diseases. Although selective manipulation of LC not possible humans, studies have suggested that strong activation might shift network connectivity favor salience processing. To test this hypothesis, we use a mouse model study impact stimulation on large-scale functional by combining chemogenetic with resting-state...
The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain, regulates many fundamental brain functions, and is implicated in several neuropsychiatric diseases. Although selective manipulation of LC not possible humans, studies have suggested that strong activation might shift network connectivity favor salience processing. To test this hypothesis, we use a mouse model study impact stimulation on large-scale functional by combining chemogenetic with resting-state fMRI, an...
Summary The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, little is known about the nature dynamics of underlying molecular cascades. We used a brief forced swim exposure trigger strong in mice, which transiently increases anxiety, but does not lead lasting maladaptive behavioral changes. Using multiomic profiling we characterize stress-induced events hippocampus over time, across scales, down level cell types single cells. Our...
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains major challenge. Here we combine RNA-sequencing with selective pharmacological, chemogenetic and optogenetic manipulations isolate contribution locus coeruleus - noradrenaline (LC-NA) system stress response. We reveal that NA-release during exposure regulates large reproducible set genes dorsal ventral...
Abstract Background Takotsubo syndrome (TTS) is a stress-induced acute cardiomyopathy characterized by transient left ventricular (LV) dysfunction without obstructive coronary artery disease. TTS often underdiagnosed and undertreated typically occurs in middle-aged women who recover from initial symptoms within few weeks. Despite the apparent recovery, patients have worse cardiovascular prognosis compared to healthy individuals. To date, pathophysiology underlying remains unclear. So far,...
Abstract In developing brain neuronal migration, dendrite outgrowth and dendritic spine are controlled by Cdc42, a small GTPase of the Rho family, its activators. Cdc42 function in promoting actin polymerization is crucial for glutamatergic synapse regulation. Here, we focus on GABAergic synapse-specific activator collybistin (CB) examine functional differences between splice isoforms CB1 CB2. We report that CB2 differentially regulate formation vitro along proximal-distal axis adult-born...
Exposure to an acute stressor triggers a complex cascade of neurochemical events in the brain. However, deciphering their individual impact on stress-induced molecular changes remains major challenge. Here we combine RNA-sequencing with selective pharmacological, chemogenetic and optogenetic manipulations isolate contribution locus coeruleus - noradrenaline (LN-NA) system stress response. We reveal that NA-release during exposure regulates large reproducible set genes dorsal ventral...