A5034401560- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Neuroscience and Music Perception
- Mental Health Research Topics
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Mental Health and Psychiatry
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Child and Adolescent Psychosocial and Emotional Development
- Digital Mental Health Interventions
- Psychosomatic Disorders and Their Treatments
- Autism Spectrum Disorder Research
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Hearing Loss and Rehabilitation
- Dementia and Cognitive Impairment Research
- Music Therapy and Health
- Neuroscience, Education and Cognitive Function
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Educational and Psychological Assessments
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Health Systems, Economic Evaluations, Quality of Life
- Family Caregiving in Mental Illness
University of Minnesota Medical Center
1977-2024
University of Minnesota
2017-2023
University of California, San Francisco
2011-2020
San Francisco VA Medical Center
2009-2019
University of Minnesota System
2017-2019
Northern California Institute for Research and Education
2009-2015
San Francisco VA Health Care System
2014
Institute of Behavioral Sciences
2009-2013
Vanderbilt University
2012
United States Department of Veterans Affairs
2011
Objective: Impaired verbal memory in schizophrenia is a key rate-limiting factor for functional outcome, does not respond to currently available medications, and shows only modest improvement after conventional behavioral remediation. The authors investigated an innovative approach the remediation of schizophrenia, based on principles derived from basic neuroscience learning-induced neuroplasticity. report interim findings this ongoing study. Method: Fifty-five clinically stable subjects...
Cognitive deficits that characterize schizophrenia are present in the prodrome, worsen with illness onset, and predict functional outcome. dysfunction is thus a critical target for early intervention young individuals recent onset schizophrenia. This 2-site double-blind randomized controlled trial investigated cognitive training of auditory processing/verbal learning 86 subjects (mean age 21 years). Subjects were given laptop computers to take home asked perform 40 hours or commercial...
Background: New cognitive treatments for schizophrenia are needed that drive persistent gains in cognition and functioning. Using an innovative neuroplasticity-based training approach, we report our interim findings on the effects functional outcome at 6 months after treatment. Methods: Thirty-two clinically stable subjects were randomly assigned to either targeted (TCT, N = 22) or a computer games (CGs) control condition (N 10). Twelve TCT completed 50 hours of auditory based training; 10...
Schizophrenia is treated with medications that raise serum anticholinergic activity and are known to adversely affect cognition. The authors examined the relationship between baseline cognitive performance response computerized training in outpatients schizophrenia.Fifty-five patients were randomly assigned either or a computer games control condition. A neurocognitive battery based on Measurement Treatment Research Improve Cognition (MATRICS) initiative was performed at after intervention....
Motivation deficits are common in schizophrenia, but little is known about underlying mechanisms, or the specific goals that people with schizophrenia set daily life. Using neurobiological heuristics of pleasure anticipation and effort assessment, we examined quality activities 47 41 without utilizing ecological momentary assessment. Participants were provided cell phones called 4 times a day for 7 days, asked their current upcoming goals. Activities later coded by independent raters on...
Pervasive social cognition deficits are evident early in the course of schizophrenia and directly linked to functional outcome, making them an important target for intervention. Here, we tested feasibility use, initiated evaluation efficacy, a novel, neuroplasticity-based online training program (SocialVille) young adults with schizophrenia. Schizophrenia patients (n = 17) completed 24 hours SocialVille game play either from home or at clinic, over 6–10 week period. We examined feasibility,...
Individuals at clinical high risk (CHR) for psychosis demonstrate cognitive impairments that predict later psychotic transition and real-world functioning. Cognitive training has shown benefits in schizophrenia, but not yet been adequately tested the CHR population.
Schizophrenia is characterized by dysfunction in basic auditory processing, as well higher-order operations of verbal learning and executive functions. We investigated whether targeted cognitive training processing improves neural responses to speech stimuli, how these changes relate Patients with schizophrenia performed an syllable identification task during magnetoencephalography before after 50 hours either or a computer games control. Healthy comparison subjects were assessed at baseline...
Successful social interactions rely on the ability to make accurate judgments based cues as well control influence of internal or external affective information those judgments. Prior research suggests that individuals with schizophrenia misinterpret stimuli and this misinterpretation contributes impaired functioning. We tested hypothesis for people schizophrenia, are abnormally influenced by information. Twenty-three patients 35 healthy participants rated trustworthiness faces following...
Social cognitive deficits are an important treatment target in schizophrenia, but it is unclear to what degree they require specialized interventions and which specific components of behavioral effective. In this pilot study, we explored the effects a novel computerized neuroplasticity-based auditory training delivered conjunction with social cognition (SCT) patients schizophrenia.
We previously reported the interim effects in a per protocol analysis of randomized controlled trial an innovative neuroscience-informed computerized cognitive training approach schizophrenia. Here we report on behavioral outcome measures our final sample using intent-to-treat analysis. also serum brain-derived neurotrophic factor (BDNF).Eighty-seven clinically stable participants with schizophrenia were randomly assigned to either targeted auditory (AT, N=46) or computer games control...
Individuals with schizophrenia who engage in targeted cognitive training (TCT) of the auditory system show generalized improvements. The high degree variability gains maybe due to individual differences level engagement underlying neural target.131 individuals underwent 40 hours TCT. We identified target processing efficiency by modeling subject-specific trajectories speed (APS) over time. Lowess analysis, mixed models repeated measures and latent growth curve were used examine whether APS...