A5079480008- Schizophrenia research and treatment
- Digital Mental Health Interventions
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Family Caregiving in Mental Illness
- Psychedelics and Drug Studies
- Chemical synthesis and alkaloids
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Functional Brain Connectivity Studies
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Music Perception
- Mental Health Treatment and Access
- Mental Health and Psychiatry
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Infant Health and Development
- Psychiatric care and mental health services
- Racial and Ethnic Identity Research
- Diet and metabolism studies
- Adolescent and Pediatric Healthcare
- Higher Education Research Studies
- Counseling Practices and Supervision
- Psychotherapy Techniques and Applications
University of California, San Francisco
2012-2023
Black Dog Institute
2018
Zucker Hillside Hospital
2018
University of Haifa
2018
Posit Science (United States)
2017
San Francisco VA Medical Center
2013
University of California, Los Angeles
2010
University of California, Santa Barbara
2009
Duke University Hospital
1995
Duke Medical Center
1995
The onset of schizophrenia occurs during a period critical for development social relationships and functional independence. As such, interventions that target the early course illness have potential to stave off decline restore functioning pre-illness levels. In this entirely remote study, people with recent-onset spectrum disorders (SSDs) participated in 12-week randomized controlled trial determine efficacy PRIME (personalized real-time intervention motivational enhancement), mobile-based...
Despite improvements in treating psychosis, schizophrenia remains a chronic and debilitating disorder that affects approximately 1% of the US population costs society more than depression, dementia, other medical illnesses across most lifespan. Improving functioning early course illness could have significant implications for long-term outcome individuals with schizophrenia. Yet, current gold-standard treatments do not lead to clinically meaningful outcome, partly due inherent challenges...
Individuals at clinical high risk (CHR) for psychosis demonstrate cognitive impairments that predict later psychotic transition and real-world functioning. Cognitive training has shown benefits in schizophrenia, but not yet been adequately tested the CHR population.
Background Although effective mental health treatments exist, the ability to match individuals optimal is poor, and timely assessment of response difficult. One reason for these challenges lack objective measurement psychiatric symptoms. Sensors active tasks recorded by smartphones provide a low-burden, low-cost, scalable way capture real-world data from patients that could augment clinical decision-making move field closer measurement-based care. Objective This study tests feasibility fully...
Despite decades of research and development, depression has risen from the fifth to leading cause disability in United States. Barriers progress field are (1) poor access high-quality care; (2) limited mental health workforce; (3) few providers trained delivery evidence-based treatments (EBTs). Although mobile platforms being developed give consumers greater care, too often these tools do not have empirical support for their effectiveness. In this study, we evaluated PRIME-D, a app...
Serious mental illness (SMI) is a disabling condition that develops early in life and imposes substantial economic burden. There growing belief intervention for SMI has lifelong benefits patients. However, assessing the cost-effectiveness of efforts hampered by lack evidence on long-term benefits. We addressed this using dynamic microsimulation model to estimate lifetime burden those diagnosed age twenty-five. estimated per patient $1.85 million. also found policy focused improving...
Impairments in cognition and motivation are core features of psychosis strong predictors social occupational functioning. Accumulating evidence indicates that cognitive deficits can be improved by computer-based training programs; however, barriers include access adherence to exercises. Limited evidence-based methods have been established enhance motivated behavior. In this study, we tested the effects web-based targeted (TCT) delivered conjunction with an innovative digital smartphone app...
Targeted disruption of the mouse Ftz-F1 gene, which encodes orphan nuclear receptors steroidogenic factor 1 (SF-1) and embryonal long terminal repeat-binding protein (ELP), established that this gene is essential for development primary tissues male sexual differentiation. Associated with these dramatic developmental abnormalities, all Ftz-F1-disrupted mice died in immediate postnatal period had very low glucocorticoid levels. In report, we show treatment corticosteroids markedly prolonged...
Abstract Objective Cognitive impairment in schizophrenia predicts functional outcomes and is largely unresponsive to pharmacology or psychotherapy; it thus a critical unmet treatment need. This article presents the impact of remotely completed, intensive, targeted auditory training (AT) vs control condition computer games (CG) double-blind randomized trial young adults with recent-onset schizophrenia. Method Participants (N = 147) were assessed for cognition, symptoms, functioning at...
Numerous psychosocial interventions for individuals with chronic psychotic disorders (CPD) have shown positive effects on social cognitive and functional outcome measures. However, access to engagement these remains limited. This is partly because require specially trained therapists, are not available in all clinical settings, a high scheduling burden participants, usually requiring commitment of several weeks. Delivering remotely via mobile devices may facilitate access, improve...
Therapeutic administration of psychedelics has shown significant potential in historical accounts and recent clinical trials the treatment depression other mood disorders. A randomized double-blind phase-IIb study demonstrated safety efficacy COMP360, COMPASS Pathways' proprietary synthetic formulation psilocybin, participants with treatment-resistant depression.While results are promising, works for a portion population early prediction outcome is key objective as it would allow...
Abstract Aim: This article outlines the rationale for a family‐focused psychoeducational intervention individuals at risk psychosis and explains design of randomized multisite trial to test its efficacy. Methods: Adolescents young adults that meet criteria syndrome eight participating North American Prodromal Longitudinal Study sites are randomly assigned 6‐month, 18‐session treatment prodromal youth or 3‐session enhanced care control followed over 1 year. Results: The results will determine...
Environmental risk and protective factors in schizophrenia play a significant role the development course of disorder. The following article reviews current state evidence linking variety environmental their impact on emergence psychotic disorders. include pre- perinatal insults, stress trauma, family environment, cannabis use. review is followed by case examples clinical applications to facilitate integration into practice.
Technology provides an unparalleled opportunity to remove barriers earlier identification and engagement in services for mental addictive disorders by reaching people the course of illness providing links just-in-time, cost-effective interventions. Achieving this opportunity, however, requires stakeholders challenge underlying assumptions about traditional pathways health care. In Open Forum, authors highlight key issues discussed Early Awareness Addiction Mental Illness (TEAAM-I)...