A5042712775- Receptor Mechanisms and Signaling
- Pharmacogenetics and Drug Metabolism
- Cell Image Analysis Techniques
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Genetics, Aging, and Longevity in Model Organisms
- Neuropeptides and Animal Physiology
Ghent University
2024
University of Antwerp
2021-2022
The FOXG1 transcription factor is a crucial regulator of embryonic brain development. Pathogenic variants cause syndrome. Although structural (SVs) in the non-coding region downstream have been reported 38 individuals with syndrome-like characteristics, regulatory pathomechanisms remain unknown. We identified de novo deletion an individual features, allowing us to delineate ~124 kb commonly affected (CARR). By integrating epigenomics data, 3D chromatin interaction profiles (Hi-C, UMI-4C),...
Multicellular tumor spheroids are a popular 3D tissue microaggregate model for reproducing microenvironment, testing and optimizing drug therapies using bio- nanosensors in context. Their ease of production, predictable size, growth, observed nutrient metabolite gradients important to recapitulate the niche-like cell microenvironment. However, spheroid heterogeneity variability their production methods can influence overall metabolism, viability, response. This makes it difficult choose most...