A5103152953- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Bone health and treatments
- Protein Tyrosine Phosphatases
- Osteoarthritis Treatment and Mechanisms
- Escherichia coli research studies
- Phagocytosis and Immune Regulation
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Bone Metabolism and Diseases
- Cancer Research and Treatments
- Vibrio bacteria research studies
- Cytomegalovirus and herpesvirus research
- Cytokine Signaling Pathways and Interactions
St. Jude Children's Research Hospital
2021
Zhejiang University
2017-2019
Sir Run Run Shaw Hospital
2018
T helper type 17 cells (Th17 cells) are major contributors to many autoimmune diseases. In this study, we demonstrate that the germinal center kinase family member MINK1 (misshapen/NIK-related 1) negatively regulates Th17 cell differentiation. The suppressive effect of on induction is mediated by inhibition SMAD2 activation through direct phosphorylation at T324 residue. importance differentiation was strengthened in animal model experimental encephalomyelitis (EAE). Moreover, show reactive...
Phosphatase PP2A expression levels are positively correlated to the clinical severity of systemic lupus erythematosus (SLE) and IL17A cytokine overproduction, indicating a potential role in controlling TH17 differentiation inflammation. By generating mouse strain with ablation catalytic subunit α peripheral mature T cells (PP2A cKO), we demonstrate that complex is essential for differentiation. These cKO mice had reduced cell numbers less severe disease an experimental autoimmune...
Listeria monocytogenes (L. monocytogenes), which is a facultative intracellular bacterial pathogen that causes listeriosis, widely used to study the mammalian immune response infection. After phagocytosis by professional phagocytes, L. initially contained within phagosomes, mature into phagolysosomes, where bacteria are degraded. Although and subsequent phagosome maturation essential for clearance of infectious microbial pathogens, underlying regulatory mechanisms still unclear. SNX10...