A5018502962- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Inflammasome and immune disorders
- Mast cells and histamine
- Antibiotic Resistance in Bacteria
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Pneumonia and Respiratory Infections
- Galectins and Cancer Biology
- vaccines and immunoinformatics approaches
- Traditional Chinese Medicine Analysis
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Cardiac Fibrosis and Remodeling
- Immune Response and Inflammation
- Autophagy in Disease and Therapy
- Tissue Engineering and Regenerative Medicine
- Cancer Mechanisms and Therapy
- Oral Health Pathology and Treatment
Lishui University
2016-2025
Zhejiang University
2021
Wenzhou Medical University
2020
The First People's Hospital of Wenling
2016
The development of tumor vaccines represents a significant focus within cancer therapeutics research. Nonetheless, the efficiency antigen presentation in vaccine remains suboptimal. We introduce an innovative mRNA-lipid nanoparticle platform designed to express antigenic epitopes fused with transmembrane domain and cytoplasmic tail neonatal Fc receptor (FcRn). This novel design exploits FcRn trafficking signals direct epitope-FcRn fusion toward endolysosomal degradation, thereby generating...
Phosphatase PP2A expression levels are positively correlated to the clinical severity of systemic lupus erythematosus (SLE) and IL17A cytokine overproduction, indicating a potential role in controlling TH17 differentiation inflammation. By generating mouse strain with ablation catalytic subunit α peripheral mature T cells (PP2A cKO), we demonstrate that complex is essential for differentiation. These cKO mice had reduced cell numbers less severe disease an experimental autoimmune...
Statins are competitive inhibitors of 3-hydroxy-3-methylglutaryl-CoA (HMG-A) reductase, and studies have shown that statins also anti-inflammatory immunomodulatory properties. The purpose this study was to investigate the anti-asthmatic effects pitavastatin, a type statin, in an asthma mouse model. Mice were sensitized challenged with ovalbumin (OVA) establish These mice then treated inhaled pitavastatin (5 mg/kg) or dexamethasone (2 mg/kg), latter which served as positive control. results...
The development of thymocytes to mature T cells in the thymus is tightly controlled by cellular selection, which only a small fraction equipped with proper quality TCRs progress maturation. It pivotal protect survival few cells, pass selection. However, signaling events, safeguard cell thymus, are not totally understood. In this study, protein Ser/Thr phosphorylation undergoing positive selection profiled mass spectrometry. results revealed large numbers dephosphorylation changes upon...
Probucol has antioxidant effects and inhibits inflammation. Farnesoid X receptor (FXR) is a nuclear that regulates autophagy, which regarded as the key cause of activation hepatic stellate cell (HSC). In this study, probucol on HSC autophagy in vitro vivo role FXR progress were investigated. Results showed ameliorated fibrosis increased expression liver mouse model induced by CCl4. And could alleviate lipopolysaccharide-induced vitro. addition, expression, Z-guggulsterone, an antagonist FXR,...
AMA Wu S, Wang G, Li L, Ji J. Effects of microRNA-21 on the interleukin 12/signal transducer and activator transcription 4 signaling pathway in asthmatic mice. Central European Journal Immunology. 2014;39(1):40-45. doi:10.5114/ceji.2014.42121. APA Wu, S., Wang, G., Li, L., & Ji, (2014). Immunology, 39(1), 40-45. https://doi.org/10.5114/ceji.2014.42121 Chicago Song-Quan, Guang-Li Ling-Yun Jian Ji. 2014. "Effects mice". Immunology 39 (1): Harvard pp.40-45. MLA Song-Quan et al. mice." vol. 39,...
Antigen-mediated cross-linking of IgE on mast cells triggers a signaling cascade that results in their degranulation and proinflammatory cytokine production, which are key effectors allergic reactions. We show the activation is negatively regulated by newly identified adaptor protein Tespa1. Loss Tespa1 mouse led to hyper-responsiveness stimulation via FcεRI. Mice lacking also displayed increased sensitivity IgE-mediated responses. The dysregulated KO was associated with Grb2-PLC-γ1-SLP-76...
In order to get insights into plasmid evolution and the dissemination of multidrug resistance, we performed extensive comparative genomics analyses Klebsiella pneumoniae pKF3-94 some its related plasmids. is one three plasmids isolated from K. strain KF3. Of 144 putative genes it harbors, 69 can be functionally assigned involved in transfer conjugation, leading, antimicrobial transposon function, replication. Comparison replicon sequence types revealed that carries two replicons are distinct...
Bacteria are known to cope with amino acid starvation by the stringent response signaling system, which is mediated accumulation of (p)ppGpp alarmones when uncharged tRNAs stall at ribosomal A site. While a number metabolic processes have been shown be regulatory targets in many bacteria, global impact on bacterial metabolism remains obscure. This work reports metabolomic profiling human pathogen Streptococcus pneumoniae under methionine starvation. Methionine limitation led massive overhaul...
To study the association of polymorphisms IL-18 promoter (-607C/A and -137G/C) with bronchial asthma, 120 subjects asthma were selected as experimental group (49 cases allergic rhinitis 1 71 without 2) healthy individuals control group. A polymerase chain reaction sequence-specific primer (PCR-SSP) was used to identify genotypic between groups. The results revealed that frequencies CC, CA AA genotypes at -607C/A in 18.37, 40.82 40.82%, respectively; these 32.39, 54.92 12.68%, respectively,...
Abstract Here, we used lumiflavin, an inhibitor of riboflavin, as a new potential therapeutic chemosensitizer to ovarian cancer stem‐like cells (CSCs). This study demonstrates that the enrichment riboflavin in CSCs is important cause its resistance chemotherapy. Lumiflavin can effectively reduce and sensitize effect cisplatin Diamminedichloroplatinum (DDP) on CSCs. In this study, human cell lines HO8910 were separated using magnetic bead (CD133+). We also show overexpression mRNA protein...
Abstract Background Thymocyte-expressed, positive selection-associated 1 (Tespa1) is a critical signaling molecule in thymocyte development. This study aimed to investigate the regulatory effect of Tespa1 on mast cells pathogenesis asthma and its relationship with interleukin (IL)-4/signal transducers activators transcription 6 (STAT6) pathway. Methods mRNA expression analysis IgE levels were carried out using induced sputum 33 adults stable 36 healthy controls. Tespa1- knockout mice ( −/− ,...